Apparatus equipped with sample temperature control function

    公开(公告)号:US11372013B2

    公开(公告)日:2022-06-28

    申请号:US16408279

    申请日:2019-05-09

    摘要: To suppress generation of dew condensation in temperature control space when heating temperature control is performed. In an apparatus, an air temperature control part for cooling or heating air in temperature control space has a first temperature control element for performing at least cooling of air, and a second temperature control element for performing at least heating of air downstream of the first temperature control element. In this manner, when heating temperature control is performed, cooling and dehumidification of air taken in from an air intake portion can be performed by the first temperature control element, and then heating of the dehumidified air can be performed by the second temperature control element.

    Method and device for chemical quantification using electrochemical mass spectrometry without the use of standard target compounds

    公开(公告)号:US11360058B2

    公开(公告)日:2022-06-14

    申请号:US16341622

    申请日:2017-10-25

    申请人: Ohio University

    发明人: Hao Chen

    摘要: A method of quantifying a target compound includes applying an oxidation/reduction potential to an electrochemical cell (14); measuring an electrochemical current during the application of the oxidation/reduction potential; and ionizing and directing the target compound before and after the application of the oxidation/reduction potential to a mass spectrometer (16) that measures a target compound ion intensity. The method further includes determining a target compound ion intensity change due to the application of the oxidation/reduction potential and determining a total amount of the target compound in the sample using the measured electrochemical current and the target compound ion intensity change. Determining the target compound ion intensity change may comprise either comparing the target compound ion intensity before and after the electrolysis relative to a reference peak or comparing the integrated peak area of a target compound ion in an extracted ion chromatogram before and after the electrolysis.

    ACOUSTIC MIST IONISATION AND NEWBORN DRIED BLOOD SPOT SCREENING

    公开(公告)号:US20220170895A1

    公开(公告)日:2022-06-02

    申请号:US17599286

    申请日:2020-03-30

    摘要: A method of newborn screening (“NBS”) is disclosed comprising directing ultrasonic energy or ultrasonic waves into a metabolite or analyte sample derived from a newborn, neonate or infant so as to cause a mist of charged sample droplets or sample ions to be ejected. The charged sample droplets or sample ions are then mass analysed and a determination is made as to whether or not one or more first metabolites or analytes indicative of a disorder or inborn error are present in the sample.

    REAGENT KIT FOR LC-MS ANALYSIS OF AROMATIC COMPOUNDS

    公开(公告)号:US20220128530A1

    公开(公告)日:2022-04-28

    申请号:US17570250

    申请日:2022-01-06

    发明人: Jichun HAN

    摘要: A method for analyzing aromatic compounds, and a reagent kit for LC-MS analysis of aromatic compounds. The method includes preparing a diazonium reagent, contacting aromatic compounds in a sample with the diazonium reagent to form an analyte; and measuring an amount or ratio of the analyte. The reagent kit includes a diazonium reagent, wherein the diazonium reagent includes (i) a diazonium salt that contains a diazonium ion; (ii) an amine and nitrous acid; and/or (iii) a nitrite and an acid.

    Control of a Buffer Preparation Process

    公开(公告)号:US20220128523A1

    公开(公告)日:2022-04-28

    申请号:US17430915

    申请日:2020-02-24

    申请人: Cytiva Sweden AB

    摘要: The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.