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    Biodegradable implant
    61.
    发明授权
    Biodegradable implant 有权

    公开(公告)号：US10478527B2

    公开(公告)日：2019-11-19

    申请号：US15757475

    申请日：2016-09-05

    Applicant: UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG

    Inventor： Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit ,  Poornima Ramburrun

    IPC: A61L27/48 ,  A61L27/16 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L27/56

    Abstract: This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.

    METHOD OF TREATING SPINAL DISK
    67.
    发明申请
    METHOD OF TREATING SPINAL DISK 审中-公开

    公开(公告)号：US20190231934A1

    公开(公告)日：2019-08-01

    申请号：US16361907

    申请日：2019-03-22

    Applicant: SpineOvations, Inc.

    Inventor： Stuart Young ,  Neville Alleyne ,  Nicholas John Manesis

    IPC: A61L27/48 ,  A61L27/20 ,  C08L5/08 ,  A61M5/32 ,  A61L27/16 ,  C08L33/12

    Abstract: A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

    Bone matrix compositions and methods
    70.
    发明授权
    Bone matrix compositions and methods 有权

    公开(公告)号：US10328179B2

    公开(公告)日：2019-06-25

    申请号：US14661712

    申请日：2015-03-18

    Applicant: WARSAW ORTHOPEDIC, INC.

    Inventor： Keyvan Behnam ,  David Knaack

    IPC: A61L27/36 ,  A61K35/32 ,  A61K38/01 ,  A61K38/18 ,  A61L27/12 ,  A61L27/42 ,  A61L27/48 ,  A61L27/54 ,  C07K14/51 ,  A61F2/28 ,  A61F2/30

    Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.

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