知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

1529 records (took 0.032 seconds)

    Oligosialic acid derivatives, methods of manufacture, and immunological uses
    66.
    发明授权
    Oligosialic acid derivatives, methods of manufacture, and immunological uses 有权
    低聚唾液酸衍生物，制造方法和免疫学应用

    公开(公告)号：US09333247B2

    公开(公告)日：2016-05-10

    申请号：US12168004

    申请日：2008-07-03

    Applicant: Gregory R. Moe ,  Brent T. Hagen

    Inventor： Gregory R. Moe ,  Brent T. Hagen

    IPC: A61K39/00 ,  A61K39/108 ,  A61K39/095 ,  C07K16/12 ,  G01N33/574 ,  C08B37/00 ,  C07H1/00 ,  C07H7/027 ,  C07H13/04

    CPC classification number: A61K39/0258 ,  A61K39/0011 ,  A61K39/095 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/585 ,  A61K2039/6037 ,  C07H1/00 ,  C07H7/027 ,  C07H13/04 ,  C07K16/1217 ,  C07K16/1282 ,  C08B37/0006 ,  G01N33/57484 ,  G01N2333/22 ,  G01N2333/245 ,  G01N2400/02 ,  Y02A50/474

    Abstract: The invention relates to methods of producing, and compositions comprising, an isolated alpha (2→8) or (2→9) oligosialic acid derivative bearing a non-reducing end enriched for one or more de-N-acetyl residues and resistant to degradation by exoneuraminidase. A representative production method involves: (i) treating an alpha (2→8) or (2→9) oligosialic acid precursor having a reducing end and a non-reducing end with sodium borohydride under conditions for de-N-acetylating the non-reducing end; and (ii) isolating alpha (2→8) or (2→9) oligosialic acid derivative having one or more de-N-acetylated residues and a non-reducing end that is resistant to degradation by exoneuraminidase. Isolated alpha (2→8) or (2→9) oligosialic acid derivatives that comprise a non-reducing end de-N-acetyl residue are provided, as well as antibodies specific for the derivatives, compositions comprising the derivatives, kits, and methods of use including protection against and detection of E. coli K1 and N. meningitidis bacterial infection, and in diagnosing and treating cancer.

    Abstract translation: 本发明涉及生产和组合物的方法，所述方法包含分离的α（2→8）或（2→9）寡唾液酸衍生物，其具有富含一种或多种脱-N-乙酰基残基且具有抗降解性的非还原性末端 由外源神经氨酸酶。 代表性的制备方法包括：（i）在非N-乙酰化非 - 乙酰化的条件下，用硼氢化钠处理具有还原末端和非还原末端的α（2→8）或（2→9）寡唾液酸前体， 减少结束 和（ii）分离具有一个或多个脱-N-乙酰化残基的α（2→8）或（2→9）寡唾液酸衍生物和对外源性神经氨酸酶有降解作用的非还原端。 提供了包含非还原末端de-N-乙酰基残基的分离的α（2→8）或（2→9）寡唾液酸衍生物，以及对衍生物特异的抗体，包含衍生物，试剂盒和方法的组合物 的用途，包括保护和检测大肠杆菌K1和脑膜炎奈瑟菌细菌感染，以及诊断和治疗癌症。

Patent Agency Ranking