公开(公告)号：US5898174A

公开(公告)日：1999-04-27

申请号：US925629

申请日：1997-09-09

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: H01J49/16 ,  H01J49/40

CPC classification number: H01J49/40

Abstract: A linear time-of-flight mass spectrometer which operates using ionization of analyte substances adsorbed on a sample support plate and an improvement in mass resolution through delayed acceleration of the ions in front of the sample support plate. The geometric design of the mass spectrometer consists of focusing the flight time of the ions in second or higher order by maintaining geometric requirements for the lengths of acceleration paths in the ion source relative to the field-free flight path length. In computer simulations, resolutions of flight time greater than one million have been obtained even for very high ion masses provided there is a correlation in space and velocity distribution when switching on the acceleration.

Abstract translation: 线性飞行时间质谱仪，其使用吸附在样品支持板上的分析物质的电离进行操作，并且通过样品支撑板前面的离子的延迟加速提高质量分辨率。 质谱仪的几何设计包括通过保持离子源相对于无场飞行路径长度的加速度路径的长度的几何要求，将离子的飞行时间以二次或更高次序进行聚焦。 在计算机模拟中，即使对于非常高的离子质量，飞行时间大于一百万的分辨率也可以获得，只要开启加速度时空间和速度分布有相关性。

公开(公告)号：US5763878A

公开(公告)日：1998-06-09

申请号：US620803

申请日：1996-03-28

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: H01J49/04 ,  H01J49/40 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/423 ,  H01J49/401

Abstract: The invention relates to methods and devices for the orthogonal injection of ions into a time-of-flight mass spectrometer, whereby the ions preferably originate from ion sources which are located outside of the vacuum system of the mass spectrometer. The invention consists of first introducing the ions into a multipole rod arrangement with extended pole rods which stretches orthogonally to the flight direction of the ions in the time-of-flight spectrometer, and then outpulsing the ions by means of a rapid change of the electrical field, perpendicular to the rod direction, through the intermediate space between two rods. The multipole arrangement can take the form of an ion storage device by fitting reflectors to the ends. The multipole arrangement can be filled with the aid of another multipole arrangement which takes the form of an ion guide. Damping of the ion oscillations with the aid of a collision gas leads to a collection of ions in a very thin thread on the axis of the multipole arrangement, providing the time-of-flight spectrometer with an excellent mass resolving power due to the uniform initial energy and low energy spread of the ions.

Abstract translation: 本发明涉及用于将离子正交注入飞行时间质谱仪的方法和装置，其中离子优选源自位于质谱仪真空系统外部的离子源。 本发明包括首先将离子引入具有延伸极杆的多极杆装置中，其延伸的极杆与飞行时间分光计中的离子的飞行方向正交地延伸，然后通过电气的快速变化使离子脉冲离开 垂直于杆方向，通过两个杆之间的中间空间。 通过将反射器装配到端部，多极排列可以采用离子存储装置的形式。 可以借助于采用离子导向器形式的另一多极装置来填充多极装置。 借助碰撞气体对离子振荡的阻尼导致多极排列轴线上非常薄的螺纹中的离子的集合，为飞行时间谱仪提供了优异的质量分辨能力，由于均匀的初始 能量和低能量的离子扩散。

公开(公告)号：US5739530A

公开(公告)日：1998-04-14

申请号：US656581

申请日：1996-05-31

Applicant: Jochen Franzen ,  Reemt-Holger Gabling ,  Yang Wang

Inventor： Jochen Franzen ,  Reemt-Holger Gabling ,  Yang Wang

IPC: H01J49/04 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/4265 ,  H01J49/063 ,  H01J49/067 ,  H01J49/424 ,  H01J49/4295

Abstract: The invention relates to methods and devices for the effective introduction of ions, which are stored in an RF ion guide into a quadrupole ion trap. The invention consists of arranging a switchable ion lens between the RF ion guide and the quadrupole ion trap, and introducing the ions into the quadrupole ion trap by a suitable connection of the ion lens only during the filling period, while otherwise the ions are reflected back into the RF ion guide. The filling period can be divided up and limited to the capture intervals of the quadrupole ion trap during each RF period. Measurement of the filling rate can be made by switching open the ion lens longer then the admission interval of the quadrupole ion trap, and measuring the flow of the ions passing through on the detector.

Abstract translation: 本发明涉及用于有效引入离子的方法和装置，其被存储在RF离子导向器中成四极离子阱。 本发明包括在RF离子导向器和四极离子阱之间设置可切换的离子透镜，并且仅在填充期间通过离子透镜的适当连接将离子引入到四极离子阱中，否则离子被反射回 进入RF离子导向器。 在每个RF周期期间，填充周期可以分开并限于四极离子阱的捕获间隔。 填充速率的测量可以通过开启离子透镜比四极离子阱的进入间隔更长，并测量在检测器上通过的离子的流动来进行。

公开(公告)号：US5608217A

公开(公告)日：1997-03-04

申请号：US402125

申请日：1995-03-10

Applicant: Jochen Franzen ,  Matthias Mann ,  Matthias Wilm

Inventor： Jochen Franzen ,  Matthias Mann ,  Matthias Wilm

IPC: G01N30/28 ,  G01N30/72 ,  H01J49/04 ,  H01J49/42 ,  H01J49/10

CPC classification number: H01J49/165 ,  G01N30/7266 ,  G01N2030/285

Abstract: A method is provided for analyzing analyte ions in a liquid using a spectrometer incorporating an ion trap, using a capillary nozzle adjacent an inlet aperture for the ion trap. The liquid is electrosprayed from the capillary nozzle by generating an electric field at the nozzle to ionise the said analyte and produce a beam of charged spray particles, and the beam of charged particles is injected into the ion trap through the inlet aperture. The pressure within the capillary is such that flow of the liquid through the capillary occurs only in the presence of the said electric field, and flow of ions into the ion trap is controlled by varying the electric field.

Abstract translation: 提供了一种使用包含离子阱的光谱仪来分析液体中的分析物离子的方法，其使用与离子阱的入口孔相邻的毛细喷嘴。 通过在喷嘴处产生电场来离子化所述分析物并产生一束带电的喷雾颗粒，从毛细喷嘴喷射液体，并将带电粒子束通过入口孔注入离子阱。 毛细管内的压力使得液体通过毛细管的流动仅在存在所述电场的情况下发生，并且通过改变电场来控制离子流入离子阱的流量。

公开(公告)号：US5595636A

公开(公告)日：1997-01-21

申请号：US401404

申请日：1995-03-09

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: G01N27/447 ,  G01N27/26

CPC classification number: H01J49/0418 ,  G01N27/44717

Abstract: The invention relates to the mass spectrometric analysis of separated substance samples on so-called 2-D-gel electrophoresis plates, used particularly for protein determination, with ionization of the substance samples by MALDI. The molecules of the substance samples are transferred to a thin, lacquer-like smooth matrix layer which should preferably be applied to a metal sample support. Transfer takes place directly or indirectly, for example via a polyvinylidene difluoride membrane an an intermediate carrier, by electrophoretic transport of the molecules to the matrix surface. Before transfer, the proteins may be subjected to enzymatic cutting of their amino acid chains.

Abstract translation: 本发明涉及所谓的2-D凝胶电泳板上分离的物质样品的质谱分析，特别用于蛋白质测定，通过MALDI离子化物质样品。 将物质样品的分子转移到薄的，类似漆的光滑基质层，其优选应用于金属样品载体。 转移通过例如通过聚偏二氟乙烯膜和中间载体直接或间接进行，通过将分子电泳转运到基质表面。 在转移之前，蛋白质可以进行酶切割其氨基酸链。

公开(公告)号：US5468958A

公开(公告)日：1995-11-21

申请号：US277667

申请日：1994-07-20

Applicant: Jochen Franzen ,  Yang Wang

Inventor： Jochen Franzen ,  Yang Wang

IPC: H01J49/42

CPC classification number: H01J49/424

Abstract: An ion trap is provided in which higher multipole field fractions can be switched on and off and, in addition, can be electrically tuned. Specifically, the electrodes of an ideally shaped ion trap are divided into rotationally symmetrical component electrodes positioned facing the interior of the ion trap on a hyperboloidal surface with rotationally symmetry.

公开(公告)号：US5468957A

公开(公告)日：1995-11-21

申请号：US245967

申请日：1994-05-19

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: H01J49/42

CPC classification number: H01J49/424 ,  H01J49/427

Abstract: The invention relates to an improved method and an apparatus for the mass-sequential ejection of ions from an RF quadrupole ion trap by electrical alternating fields which are generated in addition to the quadrupolar RF storage field and with different frequencies to it. In contrast to the already known ejection by a pure dipole field, the ions are here essentially ejected by a quadrupole field. The ions leave the ion trap through a perforated end cap and can be detected outside it with conventional means. A weak dipole field undertakes only excitation of the secular oscillation at the center, the amplitude increasing in linear manner in the stationary case. The more intense quadrupole field undertakes further widening of the oscillations with exponential growth in amplitudes. The dipole field is generated by an alternating voltage between the two end caps, while the quadrupole field is generated by an alternating voltage between the end caps on the one hand and the ring electrode on the other. The method is of particular use for the ions of very high masses ranging from approximately 5,000 u to 50,000 u. With the same mass resolution, it permits mass spectra to be recorded considerably quicker than the hitherto conventional use of pure dipole fields.

Abstract translation: 本发明涉及一种改进的方法和装置，用于通过除了四极RF存储场之外产生并具有不同频率的电交变场来大规模地从RF四极离子阱捕获离子。 与通过纯偶极子场已知的射出相反，这里的离子基本上被四极场喷射。 离子通过穿孔端盖离开离子阱，并可以用常规方法在其外部检测。 弱偶极场只对中心的长期振荡进行激励，在静止情况下振幅以线性方式增加。 更强烈的四极场进一步扩大振幅，幅度呈指数增长。 偶极场由两个端盖之间的交流电压产生，而四极场由一端的端盖和另一端的环形电极之间的交流电压产生。 该方法特别适用于大约5,000u至50,000u的非常高质量的离子。 以相同的质量分辨率，它允许比迄今传统使用纯偶极子场快得多的质谱。

公开(公告)号：US5347127A

公开(公告)日：1994-09-13

申请号：US996058

申请日：1992-12-23

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC classification number: H01J49/424 ,  H01J49/429

Abstract: An improvement of a fast scanning method in an ion trap mass spectrometer comprises setting the frequency and phase relationships between the ion trap storage frequency and the ion trap excitation frequency in such a way that the ions of consecutive masses each gain precisely the same "phase rhythm" or "phase sequence". The phase rhythm, or the historical succession of phase positions up to ion ejection, is optimally set in accordance with nonlinear resonance conditions used to cause ion ejection. The excitation voltage frequency is set to a value somewhat smaller that an integral fraction of the storage voltage frequency and the scan profile is set based on the excitation frequency so that the same time is required for ions of each mass to be ejected and so that precisely an integer number of cycles of the excitation frequency is used per mass.

Abstract translation: 离子阱质谱仪中快速扫描方法的改进包括设置离子阱存储频率和离子阱激发频率之间的频率和相位关系，使得连续质量的离子每个都获得精确相同的“相位节律 “或”相序“。 根据用于引起离子喷射的非线性共振条件，最佳地设定相位节奏或相位位置到离子喷射的历史继承。 励磁电压频率被设定为稍微小于基于激励频率设定存储电压频率和扫描轮廓的积分分数的值，使得每个质量块的离子需要相同的时间被喷射，并且精确地 每质量使用激励频率的整数周期。

公开(公告)号：US4220545A

公开(公告)日：1980-09-02

申请号：US935131

申请日：1978-08-21

Applicant: Jochen Franzen ,  Gerhard Weiss

Inventor： Jochen Franzen ,  Gerhard Weiss

IPC: H01J49/14 ,  H01J37/08

CPC classification number: H01J49/145

Abstract: Ionization chamber for the chemical ionization of vapors of substances in ion-molecule reactions by means of ionizing primary particles and a reactance gas, having at least one inlet opening for feeding the reaction partners and at least one outlet opening for the reaction products formed in the chamber. As shown, the ionization chamber has an elongated shape. The inlet opening for the ionizing primary particles on the one hand, and the outlet opening for the reaction products on the other hand, are arranged in alignment in opposite end walls of the ionization chamber.

Abstract translation: 电离室，用​​于通过离子化一次粒子和电抗气体离子化化学离子分子反应中的物质，其具有至少一个用于供给反应物质的入口和用于在反应物中形成的反应产物的至少一个出口 房间。 如图所示，电离室具有细长形状。 另一方面，电离一次粒子的入口开口和反应产物的出口开口在电离室的相对端壁中对准排列。

公开(公告)号：US4215411A

公开(公告)日：1980-07-29

申请号：US933921

申请日：1978-08-15

Applicant: Jochen Franzen

Inventor： Jochen Franzen

IPC: H01J49/42 ,  G06F15/52 ,  B01D59/44 ,  H01J39/50

CPC classification number: H01J49/0009 ,  H01J49/4215

Abstract: Ions from an unknown and two known masses are fed through a quadrupole mass filter to an electron multiplier detector whose digitally converted output is supplied to a data processing device. The latter controls the alternating and DC signals fed to the paired electrode rods of the filter. The data processing device performs transformations on the mass characteristic curves derived from the ions to equalize their widths, heights and shapes, and then determines the distance between the normalized curves using a voltage shifting technique to superimpose the curves one on another. The unknown mass may then be accurately determined from the separation distances.

Abstract translation: 来自未知和两个已知质量的离子通过四极质量过滤器馈送到电子倍增器检测器，其数字转换输出被提供给数据处理装置。 后者控制馈送到过滤器的成对电极棒的交流和直流信号。 数据处理装置对从离子得到的质量特征曲线进行变换，以使其宽度，高度和形状相等，然后使用电压移位技术来确定归一化曲线之间的距离，以将曲线叠加在另一个上。 然后可以从分离距离精确地确定未知质量。