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    Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors
    61.
    发明授权
    Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors 失效
    用于治疗恶性肿瘤并抑制恶性肿瘤生长和转移的方法和组合物

    公开(公告)号：US5639737A

    公开(公告)日：1997-06-17

    申请号：US360352

    申请日：1994-12-21

    申请人： David Rubin

    发明人： David Rubin

    IPC分类号： A61K31/05 ,  A61K31/085 ,  A61K31/165 ,  A61K31/195 ,  A61K31/235 ,  A61K31/70

    CPC分类号： A61K47/48092 ,  A61K31/05 ,  A61K31/085 ,  A61K31/165 ,  A61K31/195 ,  A61K31/235 ,  A61K31/70

    摘要： Growth or metastasization of malignant tumors can be inhibited by administering to a patient in need thereof sufficient lactose to block crucial lectins on the affected organ so that the tumor cells cannot anchor to other locations in the body. Lactose can be administered alone, or in combination with conjugates of cytotoxic drugs. Preferably, lactose is conjugated to a cytotoxic substance so that the primary tumor is treated concurrently with prevention of metastasis. Additionally, by conjugating a cytotoxic drug to lactose, the cytotoxic drug is maintained in close proximity to the tumor because of the receptors on the tumor which bind the lactose (and therefore the cytotoxic agent bound thereto) to the tumor cells. By using a conjugate of lactose with a cytotoxic agent, one dose is generally sufficient to destroy the receptor sites on the tumor and prevent metastasis of the tumor while treating the tumor.

    摘要翻译： 恶性肿瘤的生长或转移可以通过向有需要的患者施用足够的乳糖来阻断受影响器官上的关键凝集素，使得肿瘤细胞不能锚定到体内的其它位置而被抑制。 乳糖可以单独施用，或与细胞毒性药物的缀合物组合施用。 优选地，乳糖与细胞毒性物质缀合，使得原发肿瘤与预防转移同时治疗。 此外，通过将细胞毒性药物与乳糖结合，细胞毒性药物保持在与肿瘤非常接近的位置，因为肿瘤上的受体结合乳糖（因此与其结合的细胞毒性剂）与肿瘤细胞结合。 通过使用乳糖与细胞毒性剂的缀合物，一个剂量通常足以破坏肿瘤上的受体位点并且在治疗肿瘤时预防肿瘤的转移。

    Infant formula
    63.
    发明授权
    Infant formula 失效
    婴幼儿配方奶粉

    公开(公告)号：US5013569A

    公开(公告)日：1991-05-07

    申请号：US526096

    申请日：1990-05-21

    申请人： David Rubin

    发明人： David Rubin

    IPC分类号： A23C9/152 ,  A23C9/20 ,  A23C11/04

    CPC分类号： A23C11/04 ,  A23C9/1528 ,  A23C9/20 ,  Y10S426/801

    摘要： An infant food formulation substantially approximating human milk in fatty acid composition comprising a mixture of DHA and EPA in a ratio of approximately 3:2 by weight, immunoglobulins to mimic the immunoglobulin content of mother's milk, a source of protein, a source of carbohydrate, a source of ash, and sufficient water to provide an easily assimilable infant formula, the DHA, the EPA, and the immunoglobulins being encapsulated in capsules having a diameter of less than 350.mu..

    摘要翻译： 婴幼儿食品配方基本上接近于脂肪酸组合物中的人乳，包含按重量比计约3:2的DHA和EPA的混合物，模拟母乳的免疫球蛋白含量的免疫球蛋白，蛋白质来源，碳水化合物源， 灰分来源和足够的水以提供易于同化的婴儿配方，DHA，EPA和免疫球蛋白被包封在直径小于350微米的胶囊中。

    Millimeter-wave multiplexers
    64.
    发明授权
    Millimeter-wave multiplexers 失效
    毫米波多路复用器

    公开(公告)号：US4902992A

    公开(公告)日：1990-02-20

    申请号：US182290

    申请日：1988-03-29

    申请人： David Rubin ,  Kurt Reinke

    发明人： David Rubin ,  Kurt Reinke

    IPC分类号： H01P1/213

    CPC分类号： H01P1/2135

    摘要： A planar millimeter wave circuit for splitting a very wide input frequencyand into three or more lesser bands utilizes bandpass filters exclusively. A triplexer is made by connecting the bandpass filters with coupled line equivalents fed by a conductor with a characteristic impedance the same as the input conductor to the filters and of an appropriate length so as to make the diplexer appear open or nearly open circuited over the adjacent frequency range of a third bandpass filter used in the triplexer or, alternatively, over the adjacent frequency range of a second diplexer connected so as to form a quadruplexer.

    摘要翻译： 用于将非常宽的输入频带分割成三个或更多个较小频带的平面毫米波电路仅使用带通滤波器。 通过将带通滤波器与由导体馈送的耦合线等效物连接到具有与滤波器的输入导体相同的特性阻抗并且具有适当长度以便使双工器看起来在相邻 在三工器中使用的第三带通滤波器的频率范围，或者替代地，连接在第二双工器的相邻频率范围上，以形成四重器。

    Method of extraction and purification of polyunsaturated fatty acids from natural sources
    65.
    发明授权
    Method of extraction and purification of polyunsaturated fatty acids from natural sources 失效
    从天然来源提取和纯化多不饱和脂肪酸的方法

    公开(公告)号：US4792418A

    公开(公告)日：1988-12-20

    申请号：US810550

    申请日：1985-12-19

    申请人： David Rubin ,  Elyiahu J. Rubin

    发明人： David Rubin ,  Elyiahu J. Rubin

    IPC分类号： C09F5/02 ,  C09F5/10 ,  C09F5/00

    CPC分类号： C09F5/10 ,  C09F5/02

    摘要： To extract and purify of polyunsaturated fatty acids, particularly EPA and DHA, without cis-trans conversion, from naturally occurring oils, such as marine animal oil and various vegetable oils a mixture of free fatty acids is first extracted from the oil. The resulting mixture of pure fatty acids is then subjected to separation by means of urea complexing to remove saturated fatty acids and most mono-unsaturated fatty acids. Remaining solvent and urea are then removed from the filtrate which is then subjected to low temperature fractional crystallization in the presence of an organic solvent such as acetone. Substantially pure polyunsaturated fatty acids, especially EPA and DHA, can be separately precipitated by reducing the temperature of the filtrate in two steps. Alternatively, the volume of the filtrate is reduced in two steps and cooled to form precipitates, which are removed. The final product is a mixture of substantially pure DHA and EPA.

    摘要翻译： 从天然存在的油（例如海洋动物油和各种植物油）中提取和纯化多不饱和脂肪酸，特别是EPA和DHA，不经顺反式转化，首先从油中提取游离脂肪酸的混合物。 然后将所得的纯脂肪酸混合物通过尿素络合进行分离，以除去饱和脂肪酸和大多数单不饱和脂肪酸。 然后从滤液中除去剩余的溶剂和尿素，然后在有机溶剂如丙酮存在下进行低温分级结晶。 基本上纯的多不饱和脂肪酸，特别是EPA和DHA，可以通过两步降低滤液的温度来分别沉淀。 或者，将滤液的体积分两步降低，并冷却形成析出物，将其除去。 最终产品是基本上纯的DHA和EPA的混合物。

    .beta.-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production
    66.
    发明授权
    .beta.-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production 失效
    β-葡糖苷酸酶活性和/或pH依赖性药物及其生产方法

    公开(公告)号：US4584368A

    公开(公告)日：1986-04-22

    申请号：US951269

    申请日：1978-10-13

    申请人： David Rubin

    发明人： David Rubin

    IPC分类号： A61K51/04 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/48 ,  C07H15/00 ,  C07H15/20

    CPC分类号： A61K51/0491 ,  A61K31/7004 ,  A61K47/48092 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/48 ,  A61K2123/00 ,  C12Q2334/00 ,  G01N2333/924

    摘要： Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or is water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention. A urine test is disclosed to determine the amount of free glucuronic acid in the urine which is an indication of the presence of a tumor in the body having high .beta.-glucuronidase activity.

    摘要翻译： 具有高β-葡糖醛酸糖苷酶活性的高酸化肿瘤可以用具有对肿瘤细胞有毒性的糖苷配基的葡糖苷酸处理，其对身体的其余部分具有极大的安全性，首先以足以将非肿瘤组织的pH水平维持在足量的碱性剂 葡萄糖苷酸处理期间约7.4。 这将导致身体其余部分的β-葡萄糖醛酸酶活性失活。 公开了新的葡糖苷酸，其在酸性环境中发挥较高的毒性作用或仅在碱性环境中是水溶性的糖苷配基。 这些化合物具有上述方法的特殊用途。 通过用放射性同位素代替糖苷配基，可以进行诊断和原位放射治疗。 具有β-葡糖苷酸酶活性的细菌细胞也可以根据本发明进行诊断和治疗。 公开了尿液测试以确定尿液中游离葡萄糖醛酸的量，其表示具有高β-葡萄糖醛酸酶活性的体内肿瘤的存在。

    Millimeter wave suspended substrate multiplexer
    68.
    发明授权
    Millimeter wave suspended substrate multiplexer 失效
    毫米波悬浮衬底多路复用器

    公开(公告)号：US4433314A

    公开(公告)日：1984-02-21

    申请号：US341357

    申请日：1982-01-21

    申请人： Alfred R. Hislop ,  David Rubin

    发明人： Alfred R. Hislop ,  David Rubin

    IPC分类号： H01P1/213

    CPC分类号： H01P1/2135

    摘要： A millimeter wave suspended substrate multiplexer is disclosed which is comprised of a plurality of hybrid-filter-hybrid channel dropping sections. The components of the multiplexer are enclosed in a metallic housing forming a cavity surrounding the multiplexer components. Each of the hybrid-filter-hybrid sections is comprised of first and second 90.degree. hybrid couplers which are connected by a pair of identical bandpass filters. Spurious waveguide energy propagation modes which would otherwise be generated in the cavity surrounding the 90.degree. suspended hybrid couplers are eliminated by the use of a plurality of mode suppression pins extending between the top and bottom portions of the metallic housing and passing through the branch lines of the couplers.

    摘要翻译： 公开了一种毫米波悬浮衬底多路复用器，其由多个混合滤波器 - 混合信道丢弃部分组成。 多路复用器的组件被封装在金属外壳中，形成围绕多路复用器部件的空腔。 每个混合滤波器混合部分由第一和第二90度混合耦合器组成，其通过一对相同的带通滤波器连接。 否则将在围绕90°悬浮的混合耦合器的空腔中产生的杂散波导能量传播模式通过使用在金属壳体的顶部和底部之间延伸并穿过金属壳体的分支线路的多个模式抑制销来消除 耦合器。