公开(公告)号：US4327074A

公开(公告)日：1982-04-27

申请号：US011619

申请日：1979-02-12

申请人： David Rubin ,  David Rubin

发明人： David Rubin ,  David Rubin

IPC分类号： A61K51/04 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/50 ,  A61K49/00 ,  A61K43/00

CPC分类号： A61K51/0491 ,  A61K31/7004 ,  A61K47/48092 ,  C07H15/18 ,  C07H15/203 ,  C12Q1/34 ,  G01N33/5091 ,  A61K2123/00 ,  C12Q2334/00 ,  G01N2333/924

摘要： Hyperacidified tumors having high .beta.-glucuronidase activity can be treated with glucuronides with aglycones toxic to the tumor cells with great safety toward the rest of the body by first administering an alkalinizing agent in an amount sufficient to maintain the pH level of non-tumor tissues at approximately 7.4 during the glucuronide treatment. This will cause inactivation of .beta.-glucuronidase activity in the rest of the body. Novel glucuronides are disclosed the aglycones of which exert a higher toxic effect in an acid environment or is water-soluble only in an alkaline environment. Such compounds have particular utility with the above process. By substituting radioisotopes into the aglycone, diagnosis and in situ radiation therapy may be accomplished. Bacterial cells having .beta.-glucuronidase activity may also be diagnosed and treated in accordance with the present invention. A urine test is disclosed to determine the amount of free glucuronic acid in the urine which is an indication of the presence of a tumor in the body having high .beta.-glucuronidase activity.

摘要翻译： 具有高β-葡糖醛酸糖苷酶活性的高酸化肿瘤可以用具有对肿瘤细胞有毒性的糖苷配基的葡糖苷酸处理，其对身体的其余部分具有极大的安全性，首先以足以将非肿瘤组织的pH水平维持在足量的碱性剂 葡萄糖苷酸处理期间约7.4。 这将导致身体其余部分的β-葡萄糖醛酸酶活性失活。 公开了新的葡糖苷酸，其在酸性环境中发挥较高的毒性作用或仅在碱性环境中是水溶性的糖苷配基。 这些化合物具有上述方法的特殊用途。 通过用放射性同位素代替糖苷配基，可以进行诊断和原位放射治疗。 具有β-葡糖苷酸酶活性的细菌细胞也可以根据本发明进行诊断和治疗。 公开了尿液测试以确定尿液中游离葡萄糖醛酸的量，其表示具有高β-葡萄糖醛酸酶活性的体内肿瘤的存在。

公开(公告)号：US08409235B2

公开(公告)日：2013-04-02

申请号：US12771537

申请日：2010-04-30

申请人： Joshua David Rubin

发明人： Joshua David Rubin

IPC分类号： A61B17/32

CPC分类号： A61B17/16 ,  A61B17/32 ,  A61B17/32002 ,  A61B17/320783

摘要： A surgical cutting instrument including two coaxially arranged tubular members. The first tubular member has a cutting tip and is co-axially disposed within the second tubular member, which in turn has a cutting window to expose the cutting tip to tissue and bone through the cutting window. Movement of the tubular members with respect to each other debrides soft tissue and thin bone presented to the cutting window. The second (outer) tubular member has one or more features which contribute to reduced clogging of the cutting tip as a whole.

公开(公告)号：US20110270293A1

公开(公告)日：2011-11-03

申请号：US12771699

申请日：2010-04-30

申请人： Aayush Malla ,  Charles Stanislaus ,  Joshua David Rubin ,  William C. Brunnett

发明人： Aayush Malla ,  Charles Stanislaus ,  Joshua David Rubin ,  William C. Brunnett

IPC分类号： A61B17/32 ,  A61B17/14

CPC分类号： A61B17/3205 ,  A61B17/32 ,  A61B17/32002 ,  A61B2217/005 ,  A61B2217/007 ,  A61M3/0229

摘要： A surgical tissue cutting instrument having an irrigation system comprises an elongate tubular outer member having a proximal end, a distal end and an opening at the distal end, an elongate inner member rotatably disposed within the outer member and having a proximal end, a distal end and a cutting element at the distal end exposed from the opening, a handpiece mounted to the proximal ends of the outer and inner members, and an irrigation system comprising an irrigation channel composed of a first irrigation passage within the handpiece and a second irrigation passage within the thickness of the annular wall of the outer member, and a sleeve having a rearward end disposed over a front end of the handpiece and a forward end disposed over the outer member adjacent an outlet opening of the second irrigation passage near the distal end of the outer member. The sleeve is disposed over the outer member with a snug fit while allowing communication through the outlet opening of the second irrigation passage, whereby the irrigation channel is enclosed and sealed between an inlet port of the first irrigation passage and the outlet opening of the second passage. The inlet port is connectible with a source of irrigation fluid for flow through the irrigation channel to be discharged from the outlet opening near the distal end of the outer member.

摘要翻译： 具有冲洗系统的手术组织切割器具包括细长的管状外部构件，其具有近端，远端和在远端的开口，细长的内部构件，可旋转地设置在外部构件内并且具有近端，远端 以及从所述开口暴露的所述远端处的切割元件，安装到所述外部构件和所述内部构件的近端的手持件以及包括由所述手持件内的第一冲洗通道和所述第二冲洗通道内的第二冲洗通道组成的冲洗通道的冲洗通道， 外部构件的环形壁的厚度以及设置在手持件的前端上的后端的套筒以及靠近第二冲洗通道的远端附近的与第二冲洗通道的出口相邻的外部构件的前端 外部成员。 套筒设置在外部构件上方，具有紧密配合，同时允许通过第二冲洗通道的出口连通，从而冲洗通道被封闭并密封在第一冲洗通道的入口和第二通道的出口之间 。 入口可与冲洗流体源连接，用于流过冲洗通道，以从外部构件的远端附近的出口开口排出。

公开(公告)号：US20070020340A1

公开(公告)日：2007-01-25

申请号：US11188124

申请日：2005-07-25

申请人： David Rubin ,  Eyal Rubin

发明人： David Rubin ,  Eyal Rubin

IPC分类号： A61K36/02 ,  A61K35/60 ,  A61K31/22 ,  A61K31/05 ,  A01N31/08

CPC分类号： A61K31/08 ,  A61K31/05 ,  A61K31/22 ,  A61K35/60 ,  A61K2300/00

摘要： A composition containing EPA and EHA, preferably derived from fish oil, in combination with at least one of oleuropein, allicin, and policosanol having anti-inflammatory, anti-thrombotic, immunomodulatory activity as well as activity to lower triglycerides and low density lipoprotein, to increase high density lipoprotein, and to lower both systolic and diastolic blood pressure.

摘要翻译： 含有EPA和EHA的组合物，优选衍生自鱼油，与至少一种具有抗炎，抗血栓形成，免疫调节活性的橄榄苦苷，大蒜素和乳糖醇的组合以及降低甘油三酯和低密度脂蛋白的活性， 增加高密度脂蛋白，降低收缩压和舒张压。

公开(公告)号：US07156895B2

公开(公告)日：2007-01-02

申请号：US10751938

申请日：2004-01-07

申请人： David Rubin ,  Eyal Rubin

发明人： David Rubin ,  Eyal Rubin

IPC分类号： B01D47/02

CPC分类号： B01D53/78 ,  B01D47/021 ,  B01D53/77 ,  B01D2251/21 ,  B01D2257/708 ,  B01D2257/90 ,  B01D2257/91

摘要： A system for cleaning air wherein the air to be cleaned is bubbled up through an aqueous phase and an organic phase. The air is bubbled upwardly through the liquid to take advantage of the weight of the liquid to compress the gas, thereby increasing the solubility of the gas in the liquid. Because of specific gravity, the aqueous phase is generally at the bottom of at least one cylinder or container, and the organic phase is generally on top of the aqueous phase. Gases are removed either continuously or periodically to ensure that there are adequate reagents in the aqueous and organic phases, so that the reagents therein can be replaced as needed. There is no limit to the number of cylinders that can be used, depending upon the impurity and thus the amount of reagents to be used in treating the air.

摘要翻译： 一种用于清洁空气的系统，其中待清洁的空气通过水相和有机相鼓泡。 空气向上鼓泡通过液体以利用液体的重量来压缩气体，从而增加气体在液体中的溶解度。 由于比重，水相通常位于至少一个圆筒或容器的底部，有机相通常位于水相的顶部。 连续或周期性地除去气体，以确保在水相和有机相中存在足够的试剂，从而可根据需要更换其中的试剂。 取决于杂质和用于处理空气的试剂的数量，可以使用的气瓶数量没有限制。

公开(公告)号：US06786361B2

公开(公告)日：2004-09-07

申请号：US10067577

申请日：2002-02-07

申请人： Martin Joseph Moothart ,  David Rubin Aslin

发明人： Martin Joseph Moothart ,  David Rubin Aslin

IPC分类号： B67D564

CPC分类号： B67D3/0009

摘要： A primarily cylindrical beverage cooling despiser (10), devised of two separate portions, by which collectively make up the exterior and interior. The upper portion consists of two separate chambers, one interior chamber (14) for containment of ice for cooling, and one exterior chamber (12) for containment of beverage. Both chambers though mutually exclusive of each other, once filled with their intended containment by virtue of their connective proximity to one another associate a thermal communication with one another resulting in the cooling of contained beverage. Additionally the upper portion includes a lid (56), comprised as a common two-in-one combination lid. The bottom portion of the exterior is represented as the base (16), which supports the upper portions contents and additionally supports a tap/faucet (18), and tap/faucet handle (20) arrangement for the controlled release of the contained beverage content.

摘要翻译： 一个主要为圆柱形的饮料冷却除冰器（10），设计为两个分开的部分，通过它们共同组成外部和内部。上部由两个分离的室组成，一个用于容纳冰以冷却的内部室（14），一个 用于容纳饮料的外部室（12）。 两个腔室彼此相互排斥，一旦充满其预期的容纳物，由于它们彼此的连接接近而相互连接，导致所含饮料的冷却。 此外，上部包括盖（56），其包括作为公用的两合一组合盖。外部的底部部分表示为基部（16），其支撑上部内容物并另外支撑龙头/ 龙头（18）和用于控制释放所含饮料内容物的龙头/水龙头手柄（20）布置。

公开(公告)号：US06434549B1

公开(公告)日：2002-08-13

申请号：US09458836

申请日：1999-12-13

申请人： Gene Linetsky ,  David Rubin

发明人： Gene Linetsky ,  David Rubin

IPC分类号： G06F1730

CPC分类号： G06F17/30861 ,  Y10S707/99933 ,  Y10S707/99935

摘要： A system for machine- and human-mediated exchange of information, provided in response to receipt of an information query. The received query is first assigned to a selected category or classification, by a human classifier or through automatic parsing of the statement of the query by a computer. A search for a positive response to the query is performed automatically, using an information repository (including, but not limited to, one or more databases) that corresponds to the query classification. If the repository provides no positive response, the system allows a group of one or more human responders having relevant information to bid on providing a positive response to the query. A responder can also route the query to other responders. Optionally, a responder cost bid is compared with a user-supplied upper limit on cost. If a bid is accepted and the responder is selected, the responder provides a positive response to the query. Each positive response is provided for review by the source of the query, and the query source may modify the query in response to information received. Optionally, one or more time intervals may be specified for response to a query. Optionally, an information seeker can gain access to and use a query submitted by, and a pre-existing query response received by, a preceding information seeker and may engage in a chat session with one or more responders and with other information seekers.

摘要翻译： 一种用于机器和人为中介的交换信息的系统，响应于收到信息查询而提供。 接收到的查询首先由人类分类器分配给所选类别或分类，或通过计算机自动解析查询语句。 使用对应于查询分类的信息库（包括但不限于一个或多个数据库）自动执行对查询的肯定响应的搜索。 如果存储库没有提供积极的响应，系统允许一组具有相关信息的人类响应者出价提供对查询的肯定响应。 响应者也可以将查询路由到其他响应者。 可选地，将响应者成本出价与用户提供的成本上限进行比较。 如果接受出价并且选择了响应者，则响应者对查询提供肯定的响应。 每个肯定的响应都被提供给查询源进行审查，并且查询源可以根据收到的信息修改查询。 可选地，可以指定一个或多个时间间隔以响应于查询。 可选地，信息搜索者可以访问并使用由前面的信息搜索者接收到的查询和预先存在的查询响应，并且可以与一个或多个响应者和其他信息搜索者进行聊天会话。

公开(公告)号：US5340803A

公开(公告)日：1994-08-23

申请号：US57666

申请日：1993-05-05

申请人： David Rubin

发明人： David Rubin

IPC分类号： A61K31/05 ,  A61K31/085 ,  A61K31/165 ,  A61K31/195 ,  A61K31/235 ,  A61K31/70 ,  A61K47/48 ,  A01N43/04 ,  C07G3/00 ,  C07H15/00

CPC分类号： A61K47/48092 ,  A61K31/05 ,  A61K31/085 ,  A61K31/165 ,  A61K31/195 ,  A61K31/235 ,  A61K31/70 ,  A61K47/48023

摘要： Tumor cells which have .beta.-glucuronidase and tyrosinase activity are selectively treated by administration of a conjugate of a cytotoxic compound which is a substrate for tyrosinase and glucuronic acid or a pharmaceutically acceptable salt or ester thereof particularly the methyl-triacetylated form of glucuronic acid. Among the cytotoxic phenolic compounds which are substrates for tyrosinase which can be used are 4-hydroxyanisole, butylated hydroxyanisole, L-3,4-dihydroxy-phenylalanine, dopamine (3,4-dihydroxyphenethylamine), terbutylcatechol, hydroquinone, resorcinol, 6-hydroxydopa (3,4,6-trihydeoxyphenylalanine) and methyl gallate.The efficacy of the treatment is enhanced by also administering a compound that inhibits the action of glutathione reductase.

摘要翻译： 具有β-葡糖苷酸酶和酪氨酸酶活性的肿瘤细胞通过施用作为酪氨酸酶和葡糖醛酸的底物的细胞毒性化合物或其药学上可接受的盐或酯，特别是葡萄糖醛酸的甲基 - 三乙酰化形式的缀合物来选择性地治疗。 作为可用于酪氨酸酶的底物的细胞毒性酚类化合物是4-羟基苯甲醚，丁基化羟基苯甲醚，L-3,4-二羟基 - 苯丙氨酸，多巴胺（3,4-二羟基苯乙胺），叔丁基儿茶酚，氢醌，间苯二酚，6-羟基多巴 （3,4,6-三羟基苯丙氨酸）和没食子酸甲酯。 通过施用抑制谷胱甘肽还原酶作用的化合物，可以提高治疗效果。

公开(公告)号：US5240914A

公开(公告)日：1993-08-31

申请号：US995013

申请日：1992-12-22

申请人： David Rubin

发明人： David Rubin

IPC分类号： A61K31/325 ,  A61K47/48

CPC分类号： A61K47/48023 ,  A61K31/325

摘要： The metabolism of tumor cells which have .beta.-glucuronidase activity is inhibited by administering to a patient a conjugate of glucuronic acid and a thiocarbamate compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are selected from the group consisting of C.sub.1 -C.sub.6 alkyl and C.sub.1 -C.sub.6 cycloaliphatic, and M is selected from the group consisting of hydrogen, an electropositive, ionically bonded metal, and the radical ##STR2## and R.sup.3 and R.sup.4 are selected from the group consisting of C.sub.1 -C.sub.6 alkyl and C.sub.1 -C.sub.6 cycloaliphatic groups.

摘要翻译： 具有β-葡糖苷酸酶活性的肿瘤细胞的代谢通过向患者施用下式的葡糖醛酸和硫代氨基甲酸酯化合物的缀合物来抑制：其中R1和R2选自C1-C6烷基和 C1-C6脂环族基团，M选自氢，正电，离子键合的金属和基团，并且R 3和R 4选自C 1 -C 6烷基和C 1 -C 6脂环族基团 。

公开(公告)号：US5169858A

公开(公告)日：1992-12-08

申请号：US833801

申请日：1986-02-26

申请人： David Rubin

发明人： David Rubin

IPC分类号： A61K31/11 ,  A61K20060101 ,  A61K31/425 ,  A61K31/426 ,  A61K51/00 ,  C07D277/06

CPC分类号： C07D277/06 ,  A61K31/425

摘要： A composition for therapy of tumors having high tyrosinase activity contains the reaction product of penicillamine with a cytotoxic aldehyde, or pharmaceutically acceptable salts or esters thereof, and a pharmaceutically acceptable vehicle. The preferred compounds are 5,5-dimethyl-2-phenyl-4-thiazolidine carboxylic acid or 5,5-dimethyl-2-(2-hydroxyphenyl)-4-thiazolidine carboxylic acid, or pharmaceutically acceptable salts or esters thereof. Treatment preferably comprises an intra-arterial drip. Diagnosis of tumors suitable for treatment by means of these compositions may be accomplished by administering a radioactive copper salt and scanning for accumulations of radioactivity. This will indicate sites of high tyrosinase activity.

摘要翻译： 用于治疗具有高酪氨酸酶活性的肿瘤的组合物包含青霉胺与细胞毒性醛或其药学上可接受的盐或酯的反应产物和药学上可接受的载体。 优选的化合物是5,5-二甲基-2-苯基-4-噻唑烷羧酸或5,5-二甲基-2-（2-羟基苯基）-4-噻唑烷羧酸或其药学上可接受的盐或酯。 治疗优选包括动脉内滴注。 适用于通过这些组合物治疗的肿瘤的诊断可以通过施用放射性铜盐并扫描放射性的积累来实现。 这将表明高酪氨酸酶活性的位点。