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    Pyrido[3,2-d]Pyridazine-2(1H)-One Compounds as p38 Modulators and Methods of Use Thereof
    69.
    发明申请
    Pyrido[3,2-d]Pyridazine-2(1H)-One Compounds as p38 Modulators and Methods of Use Thereof 失效
    吡啶并[3,2-d]哒嗪-2（1H） - 一种作为p38调节剂的化合物及其使用方法

    公开(公告)号：US20110281864A1

    公开(公告)日：2011-11-17

    申请号：US13060675

    申请日：2009-08-26

    Applicant: Liping H. Pettus ,  Andrew Tasker ,  Bin Wu

    Inventor： Liping H. Pettus ,  Andrew Tasker ,  Bin Wu

    IPC: A61K31/5025 ,  A61K31/5377 ,  A61P29/00 ,  A61P1/00 ,  A61P1/04 ,  A61P31/16 ,  A61P11/00 ,  A61P19/08 ,  A61P35/02 ,  A61P3/10 ,  A61P25/28 ,  A61P9/10 ,  C07D471/04 ,  A61P11/06

    CPC classification number: C07D471/04

    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein R1, R2, R3, R4, R5, W and X are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中R 1，R 2，R 3，R 4，R 5，W和X如本文所定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，银屑病，慢性阻塞性肺病，疼痛和其它炎性疾病以及中间体 和可用于制备式I化合物的方法。

    Pyrazolo-Pyrazinone Compounds and Methods of Use Thereof
    70.
    发明申请
    Pyrazolo-Pyrazinone Compounds and Methods of Use Thereof 有权
    吡唑并吡唑酮类化合物及其使用方法

    公开(公告)号：US20110105499A1

    公开(公告)日：2011-05-05

    申请号：US12933406

    申请日：2009-03-19

    Applicant: Andrew Tasker

    Inventor： Andrew Tasker

    IPC: A61K31/4985 ,  C07D471/04 ,  A61K31/5355 ,  A61P19/08 ,  A61P19/10 ,  A61P35/02 ,  A61P1/00 ,  A61P11/00 ,  A61P3/10 ,  A61P25/28 ,  A61P37/06 ,  A61P9/10 ,  A61P31/16 ,  A61P17/06 ,  A61P29/00 ,  A61P19/02

    CPC classification number: C07D487/04

    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, B, R1, R2, R3, R4, R5 and n are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

    Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A1，B，R1，R2，R3，R4，R5和n如本文所定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗p38地图激酶介导的疾病包括类风湿性关节炎，银屑病，慢性阻塞性肺病，疼痛和其它炎性疾病以及中间体 和可用于制备式I化合物的方法。

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