公开(公告)号：US07521589B2

公开(公告)日：2009-04-21

申请号：US11400572

申请日：2006-04-06

Applicant: Tracy Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

Inventor： Tracy Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

IPC: A01K67/00 ,  A01K67/033

CPC classification number: A61K31/401 ,  A61K49/0008

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

公开(公告)号：US07034201B2

公开(公告)日：2006-04-25

申请号：US10728357

申请日：2003-12-04

Applicant: Tracy Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

Inventor： Tracy Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

IPC: A01K67/00

CPC classification number: A61K49/0008 ,  A61K31/198

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

公开(公告)号：US07622101B2

公开(公告)日：2009-11-24

申请号：US11400571

申请日：2006-04-06

Applicant: Tracey Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

Inventor： Tracey Doucette ,  Henriette Husum Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

IPC: A61K49/00

CPC classification number: A61K31/401 ,  A61K49/0008

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

Abstract translation: 公开了颞叶癫痫和其他癫痫相关疾病的发育动物模型。 特别地，本发明提供了诱导啮齿动物（例如大鼠）的神经发育的永久性变化的方法，其包括在第二个出生后周期内向动物中每日施用低剂量的红藻氨酸受体激动剂，其中在用 当暴露于轻度至中度的应激物时，该动物的红藻氨酸受体激动剂显示可重现的发作样症状。 使用上述方法治疗的大鼠特别可用作研究颞叶癫痫的非人系统，以及用于研究潜在的抗癫痫化合物和药物制剂的功效。

公开(公告)号：US20050124695A1

公开(公告)日：2005-06-09

申请号：US10728357

申请日：2003-12-04

Applicant: Tracy Doucette ,  Henriette Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

Inventor： Tracy Doucette ,  Henriette Bak-Jensen ,  Melissa Perry ,  Catherine Ryan ,  R. Andrew Tasker

IPC: A01K67/027 ,  A01N37/12 ,  A61K31/198 ,  A61K31/40 ,  A61K49/00 ,  C12Q1/00

CPC classification number: A61K49/0008 ,  A61K31/198

Abstract: Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

Abstract translation: 公开了颞叶癫痫和其他癫痫相关疾病的发育动物模型。 特别地，本发明提供了诱导啮齿动物（例如大鼠）的神经发育的永久性变化的方法，其包括在第二个出生后周期内向动物中每日施用低剂量的红藻氨酸受体激动剂，其中在用 当暴露于轻度至中度的应激物时，该动物的红藻氨酸受体激动剂显示可重现的发作样症状。 使用上述方法治疗的大鼠特别可用作研究颞叶癫痫的非人系统，以及用于研究潜在的抗癫痫化合物和药物制剂的功效。