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533 条记录 (耗时 0.033 秒)

    Method for screening FGFR-4 agonists
    61.
    发明授权
    Method for screening FGFR-4 agonists 失效
    筛选FGFR-4激动剂的方法

    公开(公告)号：US07531304B2

    公开(公告)日：2009-05-12

    申请号：US10503242

    申请日：2003-01-30

    申请人： Johannes Bange ,  Axel Ullrich

    发明人： Johannes Bange ,  Axel Ullrich

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/18

    CPC分类号： G01N33/74 ,  A61K38/00 ,  A61K38/1825 ,  A61K38/45 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2317/75 ,  G01N2333/71 ,  G01N2500/04 ,  A61K2300/00

    摘要： The present invention relates to the use of Fibroblast-Growth Factor Receptor (FGFR) agonists for the diagnosis, prevention and/or treatment of pathological conditions including, but not limited to hyperproliferative disorders, bone diseases and vascular diseases. Particularly, the use of FGFR-4 agonists, e.g. anti-FGFR-4 antibodies is described. Further, the invention relates to a pharmaceutical composition comprising the agonist as described above and a screening procedure.

    摘要翻译： 本发明涉及成纤维细胞生长因子受体（FGFR）激动剂用于诊断，预防和/或治疗病理状况的用途，包括但不限于过度增殖性疾病，骨疾病和血管疾病。 特别地，使用FGFR-4激动剂，例如， 描述了抗FGFR-4抗体。 此外，本发明涉及包含如上所述的激动剂和筛选程序的药物组合物。

    Chemical sensor
    62.
    发明授权
    Chemical sensor 失效
    化学传感器

    公开(公告)号：US07531136B2

    公开(公告)日：2009-05-12

    申请号：US11353378

    申请日：2006-02-14

    申请人： Isabelle Besnard ,  Tobias Vossmeyer ,  Akio Yasuda ,  Marko Burghard ,  Ulrich Schlecht

    发明人： Isabelle Besnard ,  Tobias Vossmeyer ,  Akio Yasuda ,  Marko Burghard ,  Ulrich Schlecht

    IPC分类号： G01N27/00 ,  B82B1/00 ,  G01N7/00 ,  G01R31/26

    CPC分类号： G01N27/127 ,  H01L21/02565 ,  H01L21/02601 ,  Y10S977/815 ,  Y10S977/88 ,  Y10S977/902 ,  Y10S977/92 ,  Y10S977/921

    摘要： The application relates to a chemical sensor device comprising a substrate (1), a sensor medium (3) formed on the substrate, the sensor medium comprising one-dimensional nanoparticles, wherein the one-dimensional nanoparticles essentially consist of a semiconducting AxBy compound, e.g. V2O5 and detection means (2) for detecting a change of a physical property of the sensor medium e.g. conductivity. The porosity of the sensor medium supports a fast access of the analyte to the sensing material and therefore a fast response of the sensor. The selectivity and sensitivity of the sensor can be tailored by doping the one-dimensional nanoscale material with different dopants or by varying the dopant concentration. Sensitivity of the sensor device to an analyte, preferably an amine, can be increased by increasing relative humidity of the sample to at least 5%.

    摘要翻译： 本申请涉及一种化学传感器装置，其包括基底（1），形成在基底上的传感器介质（3），所述传感器介质包括一维纳米颗粒，其中所述一维纳米颗粒基本上由半导体AxBy化合物组成。 V 2 O 5和用于检测传感器介质的物理特性变化的检测装置（2），例如 电导率。 传感器介质的孔隙度支持分析物快速进入感测材料，因此支持传感器的快速响应。 可以通过用不同掺杂剂掺杂一维纳米级材料或通过改变掺杂剂浓度来调整传感器的选择性和灵敏度。 可以通过将样品的相对湿度增加至至少5％来增加传感器装置对分析物，优选胺的敏感性。

    METHOD AND SYSTEM FOR DETECTING PHARMACOLOGICALLY ACTIVE SUBSTANCES BY MEASURING MEMBRANE CURRENTS WITH EXTRACELLULAR SENSORS
    64.
    发明申请
    METHOD AND SYSTEM FOR DETECTING PHARMACOLOGICALLY ACTIVE SUBSTANCES BY MEASURING MEMBRANE CURRENTS WITH EXTRACELLULAR SENSORS 审中-公开
    通过用细胞传感器测量膜电流来检测药物活性物质的方法和系统

    公开(公告)号：US20090032411A1

    公开(公告)日：2009-02-05

    申请号：US12278986

    申请日：2007-02-08

    申请人： Ingmar Peitz ,  Peter Fromherz

    发明人： Ingmar Peitz ,  Peter Fromherz

    IPC分类号： C12Q1/02 ,  C12M1/00 ,  C12N5/00 ,  G01N27/26 ,  C12M1/34

    CPC分类号： G01N33/554 ,  G01N27/414 ,  G01N33/48728 ,  G01N33/5438 ,  G01N33/6872

    摘要： The present invention relates to a bioelectronic device comprising a living cell which is in operative contact with an extracellular planar potential-sensitive electrode, e.g. a field effect transistor. The cell comprises first and second ion channel/receptor systems which are responsive to stimuli. The ion channels are selected such that the ion flux of the first ion channel is directed against the ion flux of the second ion channel. Thus, the device is suitable as a bioelectronic sensor. Further, the invention relates to a method for determining the response of the cell to a stimulus. The method is e.g. suitable for drug screening.

    摘要翻译： 本发明涉及一种生物电子器件，其包括与细胞外平面电位敏感电极例如与细胞外平面电位敏感电极操作性接触的活细胞。 场效应晶体管。 细胞包含响应于刺激的第一和第二离子通道/受体系统。 选择离子通道使得第一离子通道的离子通量针对第二离子通道的离子通量。 因此，该装置适合作为生物电子传感器。 此外，本发明涉及一种用于确定细胞对刺激的反应的方法。 该方法是例如 适合药物筛选。

    Nozzle Assembly
    65.
    发明申请
    Nozzle Assembly 审中-公开
    喷嘴组件

    公开(公告)号：US20080308644A1

    公开(公告)日：2008-12-18

    申请号：US11995532

    申请日：2006-07-07

    申请人： Manfred Faubel ,  Ales Charvat ,  Juergen Troe ,  Bernd Abel

    发明人： Manfred Faubel ,  Ales Charvat ,  Juergen Troe ,  Bernd Abel

    IPC分类号： B05B17/04 ,  B05B1/00

    CPC分类号： B05B1/02 ,  H01J49/0431

    摘要： The invention relates to a nozzle assembly (1) for dispensing a fluid, especially for injecting the fluid into a vacuum chamber. The nozzle assembly (1) includes a nozzle body (2) with a continuous nozzle duct (9) and a nozzle port (10) that is embodied at the discharge end and is used for discharging the fluid, and a feeding capillary tube (8) which extends co-axially in relation to the nozzle duct (9) and is used for delivering the fluid to be injected. The feeding capillary tube (8) extends into the nozzle duct (9) of the nozzle body (2) in the direction of flow in order to reduce the dead volume.

    摘要翻译： 本发明涉及一种用于分配流体的喷嘴组件（1），特别是用于将流体注入真空室。 喷嘴组件（1）包括具有连续喷嘴管道（9）和喷嘴端口（10）的喷嘴主体（2），该喷嘴主体体现在排放端处并用于排出流体;以及进料毛细管（8 ），其相对于喷嘴管道（9）同轴地延伸并且用于输送待喷射的流体。 进料毛细管（8）沿着流动方向延伸到喷嘴体（2）的喷嘴管道（9）中，以减少死体积。

    Method of fabricating carbon nanotube field-effect transistors through controlled electrochemical modification
    68.
    发明授权
    Method of fabricating carbon nanotube field-effect transistors through controlled electrochemical modification 失效
    通过控制电化学修饰制造碳纳米管场效应晶体管的方法

    公开(公告)号：US07091096B2

    公开(公告)日：2006-08-15

    申请号：US10903854

    申请日：2004-07-29

    申请人： Kannan Balasubramanian ,  Marko Burghard ,  Klaus Kern

    发明人： Kannan Balasubramanian ,  Marko Burghard ,  Klaus Kern

    IPC分类号： H01L21/336 ,  H01L39/76

    CPC分类号： B82Y10/00 ,  H01L51/0006 ,  H01L51/0048 ,  H01L51/0512 ,  H01L51/0545 ,  Y10S977/847

    摘要： The invention relates to a method of fabricating a structure with field-effect transistors each comprising a source electrode, a drain electrode, a channel extending between the source and drain electrodes and at least one gate electrode associated with the channel for controlling the conductance of the channel, wherein the channel comprises one or more semiconducting single-wall carbon nanotubes. The method includes the steps of a) depositing a plurality of single-wall carbon nanotubes on a substrate, the carbon nanotubes including a mixture of metallic carbon nanotubes and semiconducting carbon nanotubes, b) providing before or after step a) source and drain electrodes on the substrate so that one or more carbon nanotubes extend between the source and drain electrodes, c) applying a variable gate voltage to switch off the semiconducting tubes extending between the source and drain electrodes, d) wetting the surface of the structure including the transistors with a chemical to achieve a chemical bond between a radical supplied by the chemical and some carbon atoms of the metallic nanotubes, whereby these metallic nanotubes become non-conductive.

    摘要翻译： 本发明涉及一种制造具有场效应晶体管的结构的方法，每个场效应晶体管包括源电极，漏电极，在源极和漏极之间延伸的沟道以及与沟道相关联的至少一个栅极，用于控制 通道，其中所述通道包括一个或多个半导体单壁碳纳米管。 该方法包括以下步骤：a）在衬底上沉积多个单壁碳纳米管，所述碳纳米管包括金属碳纳米管和半导体碳纳米管的混合物，b）在步骤a）之前或之后提供源极和漏极上的 所述衬底使得一个或多个碳纳米管在所述源极和漏极之间延伸，c）施加可变栅极电压以切断在所述源极和漏极之间延伸的所述半导体管，d）使包括所述晶体管的所述结构的表面润湿， 化学物质，以实现由化学物质提供的基团与金属纳米管的某些碳原子之间的化学键，由此这些金属纳米管变得不导电。