公开(公告)号：US20200205788A1

公开(公告)日：2020-07-02

申请号：US16484731

申请日：2017-09-21

申请人： HANGZHOU NEW HORIZON HEALTH TECHNOLOGY CO., LTD.

发明人： Yiyou CHEN ,  Bin LI ,  Shuidi ZHONG

IPC分类号： A61B10/00 ,  G01N33/72

摘要： Disclosed is an integrated device for faeces sampling and occult blood detection, which has functions of quantitative collection, dissolution, filtration, detection with immune test strips of the faecal sample, and is convenient to carry and operate, and the device does not leak any liquid during storage, transportation and detection. The device can accurately collect a constant sample with no pollution and leakage, and can quickly determine results of occult blood without the aid of other items. The device can detect faecal occult blood at any time and at any place, can help to overcome the problem of low rate of inspection due to the inconvenience of faeces submission and inspection, further promote the detection of faecal occult blood, and can improve the early diagnosis and screening rate of colorectal cancer of the population.

公开(公告)号：US10690684B2

公开(公告)日：2020-06-23

申请号：US16157719

申请日：2018-10-11

申请人： University of Utah Research Foundation

发明人： Annette Macintyre ,  Lara Brewer Cates ,  Suzanne Wendelken ,  Quinn Tate ,  Soeren Hoehne ,  Alfred Akerman ,  Stephen W. Allison ,  Matthew B. Scudiere ,  Michael R. Cates ,  David L. Beshears ,  Adan James Akerman

IPC分类号： G01N33/72 ,  G01N33/49 ,  G01N21/31 ,  A61M1/00 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/02 ,  G01N21/85

摘要： A system for measuring the blood loss comprises a measuring device that determines the hemoglobin concentration of fluid within a container utilizing a light source and a light detector. The container receives blood and other fluids from a patient during a medical procedure. Light from the light source is passed through the blood and other fluids in the container and is detected by the light detector. Based upon a magnitude of light detected, the hemoglobin concentration of the fluid in the container can be determined. A volume-measuring device determines the volume of blood and fluid in the container. Knowing the hemoglobin concentration and volume of fluid in the container, the volume of patient blood loss in the container can be determined. The blood loss measuring device in combination with infusion systems maintains a real-blood volume status so that proper infusion of blood, crystalloid and/or colloid solutions occurs.

公开(公告)号：US10663476B2

公开(公告)日：2020-05-26

申请号：US15993503

申请日：2018-05-30

申请人： Becton, Dickinson and Company

发明人： Scott Bornheimer ,  Edward Goldberg

IPC分类号： G01N33/72 ,  G01N21/31 ,  G01J3/02 ,  G01J3/04 ,  G01N21/64 ,  G01J3/42 ,  G01N21/359 ,  G01N21/03

摘要： Aspects of the present disclosure include methods and systems for assaying a sample for an analyte. Methods according to certain embodiments include illuminating a sample with a slit-shaped beam of light, detecting light transmitted through the sample, determining absorbance of the transmitted light at one or more wavelengths and calculating concentration of the analyte based on the absorbance to assay the sample for the analyte. Systems for practicing the subject methods are also described.

公开(公告)号：US10551373B2

公开(公告)日：2020-02-04

申请号：US15259253

申请日：2016-09-08

申请人： Global Icle Test Ltd.

发明人： John Robert Anderson

IPC分类号： G01N33/493 ,  G01N21/78 ,  G01N33/72 ,  G01N21/77

摘要： There is provided a urine test device for detecting the presence of one or more compounds in urine. The test device comprises a base portion having a detection portion and a flexible attachment portion. The detection portion displays a change when the presence of any one of one or more compounds is detected in urine. The flexible attachment portion is movable from a first configuration to a second configuration in which the flexible attachment portion is extended to enable attachment to a toilet bowl.

公开(公告)号：US10533160B2

公开(公告)日：2020-01-14

申请号：US15838361

申请日：2017-12-12

申请人： Industrial Technology Research Institute

发明人： Yi-Chau Huang ,  Huai-Lo Lee ,  Yu-Yin Tsai ,  Chih-Lung Lin

IPC分类号： C12N9/02 ,  C12N9/06 ,  C12Q1/26 ,  G01N33/72

摘要： A recombinant protein and a preparation method and application thereof are provided. The recombinant protein includes a peptide, and the peptide includes an amino acid sequence after substitution of the sequence of SEQ ID NO: 1. The substitution includes at least one selected from the group consisting of the following substitutions: the amino acid at position 182 of SEQ ID NO: 1 is substituted with aspartic acid (Asp); the amino acid at position 268 of SEQ ID NO: 1 is substituted with aspartic acid (Asp); and the amino acid at position 384 of SEQ ID NO: 1 is substituted with tyrosine (Tyr). The recombinant protein is suitable for detecting glycated hemoglobin.

公开(公告)号：US20190391171A1

公开(公告)日：2019-12-26

申请号：US16562661

申请日：2019-09-06

申请人： Sysmex Corporation

发明人： Takaaki NAGAI ,  Akio TOYODA

IPC分类号： G01N35/00 ,  G01N27/08 ,  G01N21/31 ,  G01N1/38 ,  G01N33/80 ,  G01N33/72

摘要： A blood measuring device control method, the device including a sample preparing part that prepares a measurement sample by mixing a blood sample and a reagent, and a measuring part that measures the measurement sample, where the method includes preparing the reagent by mixing a high concentration reagent and pure water; and performing a washing operation by washing sites of the blood measuring device least affecting the measurement results of the measurement sample with pure water, and washing sites of the blood measuring device affecting the measurement results of the measurement sample with the reagent.

公开(公告)号：US10513705B2

公开(公告)日：2019-12-24

申请号：US15923067

申请日：2018-03-16

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： James F. Casella ,  Emily Barron-Casella ,  Jeffrey R. Keefer ,  Yolanda Fortenberry ,  Shirley H. Purvis

IPC分类号： C12N15/11 ,  C12N15/115 ,  G01N33/53 ,  G01N33/72 ,  C07K14/805

摘要： The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.

公开(公告)号：US20190353671A1

公开(公告)日：2019-11-21

申请号：US16481167

申请日：2018-01-26

申请人： Osaka University

发明人： Takeharu Nagai ,  Yoshiyuki Arai

IPC分类号： G01N33/72 ,  G01N33/68 ,  G01N33/58 ,  G01N21/76 ,  G01N21/78

摘要： Provided is a method of detecting a biological material, by which quantitative measurement can be performed easily. The method of detecting a biological material in a sample includes: mixing, with the sample, a fusion protein (C) in which a protein (A) capable of binding the biological material and a chemiluminescent protein (B) are fused together and a substrate for the chemiluminescent protein (B); and observing a luminescent signal from the sample, wherein the protein (A) and the protein (B) are linked in such a manner that resonance energy transfer can occur, the protein (A) is either a protein (A1) that can emit fluorescence in a state where the biological material is bound thereto or a protein (A2) capable of binding an autofluorescent molecule as the biological material, and the protein (B) can excite fluorescence or autofluorescence of the protein (A) with its luminescence energy.

公开(公告)号：US20190353651A1

公开(公告)日：2019-11-21

申请号：US16071153

申请日：2017-01-19

申请人： TANAKA KIKINZOKU KOGYO K.K.

发明人： Shinichi KATO ,  Aki MIYATA ,  Daisuke ITO

IPC分类号： G01N33/558 ,  G01N33/543 ,  G01N33/72 ,  B01J20/24 ,  B01J20/281

摘要： An object of the present invention is to provide a chromatographic medium having sufficiently improved storage stability. The present invention relates to a chromatographic medium having a detection part in which a detection substance composed of a protein is fixed, wherein the detection part includes a tri- or higher polysaccharide and a basic amino acid.

公开(公告)号：US20190339258A1

公开(公告)日：2019-11-07

申请号：US16513395

申请日：2019-07-16

申请人： SYSMEX CORPORATION ,  Sysmex America, Inc.

发明人： Takaaki NAGAI ,  Noriyuki NARISADA ,  Daigo FUKUMA ,  Masanori IMAZU

IPC分类号： G01N33/50 ,  G01N33/72 ,  G01N15/12 ,  G01N15/14

摘要： A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample, or a body fluid measurement mode for measuring the body fluid sample as an operating mode; and measures the measurement sample prepared from the blood sample by executing operations in the blood measurement mode when the blood measurement mode has been set, and measuring the measurement sample prepared from the body fluid sample by executing operations in the body fluid measurement mode that differs from the operations in the blood measurement mode when the body fluid measurement mode has been set, is disclosed. A computer program product is also disclosed.