公开(公告)号：US20210396763A1

公开(公告)日：2021-12-23

申请号：US17289523

申请日：2019-10-29

申请人： A2 MILK COMPANY LIMITED

发明人： Terence Patrick Cooney ,  Jacob Evan Jaine

IPC分类号： G01N33/68 ,  G01N30/72 ,  G01N33/04 ,  G01N30/06 ,  G01N30/88

摘要： A method for testing for the presence and quantification of A1-type beta-casein variants or A2-type beta-caseins, in milk and milk derived dairy products, using chymotrypsin digestion followed by LC-MS analysis to determining the concentrations of beta-casein digestion peptides and using the concentrations to calculate the amounts of A1-type beta-casein variants or A2-type beta-casein variants present.

公开(公告)号：US11202835B2

公开(公告)日：2021-12-21

申请号：US15777327

申请日：2016-11-21

申请人： Anteo Technologies Pty Ltd

发明人： Chang-Yi Huang ,  Nobuyoshi Joe Maeji

IPC分类号： A61K47/61 ,  A61K47/54 ,  G01N30/06 ,  B01D15/38 ,  A61K47/59 ,  A61K31/496 ,  A61K38/16 ,  A61K39/395 ,  C07K16/18

摘要： The present invention relates to a method of controlled competitive exchange of a first agent bound to a metal coordination complex with a competing agent, with selection of the nature of the first agent allowing a tailoring of the binding strength and thereby allowing for a desired level of control for subsequent displacement by the selected competing agent. The method may be employed for release of therapeutic agents, sequestration of larger molecules from a sample, generation of a preferred binding surface and the like.

公开(公告)号：US11199526B2

公开(公告)日：2021-12-14

申请号：US16218785

申请日：2018-12-13

申请人： ExxonMobil Research and Engineering Company

发明人： Randall S. Lachine ,  Raymond J. Henry

IPC分类号： G01N30/06 ,  G01N33/18 ,  G01N30/88 ,  G01N30/02

摘要： Systems and methods are provided for determining a content of a hydrocarbon or other compound, such as a C3 to C7 hydrocarbon, in a condensed steam sample. Cooled steam condensate can be flowed through a sample chamber including an inner overflow tube. When the flow stops, water can be drained from the sample chamber, and then the sample chamber can be opened to allow fluid communication with a vapor chamber above the sample chamber. This can allow hydrocarbons in the condensed steam (and/or other gas) to be transferred from the sample chamber into the vapor chamber. The vapor chamber can then be isolated from the sample chamber. At least a portion of the content of the vapor chamber can then be passed to a detection volume, such as the characterization cell for a gas chromatography system.

公开(公告)号：US20210364498A1

公开(公告)日：2021-11-25

申请号：US17207295

申请日：2021-03-19

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Anthony T. Le

IPC分类号： G01N33/50 ,  G01N30/06 ,  G01N30/72

摘要： Disclosed herein are methods of analyzing a biological sample comprising: separating components of the biological sample via reversed-phase (RP) chromatography to obtain an elute; subjecting the elute to separation via ion-exchange (IEX) chromatography or mixed-mode IEX chromatography; and detecting the separated compounds to determine the components of the biological sample. Also disclosed are devices comprising a reversed-phase (RP) chromatography column in communication with an ion-exchange (IEX) chromatography column or mixed-mode IEX chromatography column, wherein there is no switching valve between the columns.

公开(公告)号：US11162924B2

公开(公告)日：2021-11-02

申请号：US16691927

申请日：2019-11-22

申请人： SHIMADZU CORPORATION

发明人： Nobuhiro Hanafusa ,  Kazuhiro Suzuki

IPC分类号： G01N30/24 ,  G01N35/02 ,  G01N30/88 ,  G01N35/00 ,  G01N1/10 ,  G01N35/04 ,  G01N27/62 ,  G01N30/36 ,  G01N30/06 ,  G01N35/10

摘要： The present invention provides a processing device with a high degree of flexibility in setting of preprocessing and which is capable of increasing the preprocessing efficiency, and an analysis system provided with the same. Setting receiving means (84d) receives, for each sample, setting of a plurality of types of preprocessing and a parameter for each preprocessing. A preprocessing execution section (84e) controls a plurality of preprocessing sections and a transport arm (24) so that a plurality of types of preprocessing set for each of different samples is performed simultaneously in parallel. The preprocessing execution section (84e) performs control in such a way that preprocessing is not to be performed on different samples at the same preprocessing section at the same.

公开(公告)号：US20210333250A1

公开(公告)日：2021-10-28

申请号：US17050455

申请日：2020-05-18

申请人： NANJING UNIVERSITY

发明人： Si WEI ,  Yuqian LI ,  Hongxia YU ,  Nanyang YU

IPC分类号： G01N30/86 ,  G16B5/00 ,  G01N30/72 ,  G01N30/06

摘要： Disclosed is a method for high-throughput screening of non-target biomarkers based on metabolic disturbance caused by pollutants, belonging to the field of environmental exposure and health. The method includes the following steps: (1) extracting to obtain extracts to be tested; (2) performing chromatographic analysis to obtain a spectrum containing chromatographic peaks; (3) identifying and labeling features of pollutants, taking chromatographic peaks other than the features of the pollutants as features of potential metabolites, and performing non-target labeling of the features of the potential metabolites; (4) establishing a linear regression model by taking the peak areas of the features of the potential metabolites as dependent variables and the peak areas of the features of the pollutants as independent variables; (5) operating the model, and performing non-target screening of the biomarkers to preliminarily obtain related biomarkers; (6) identifying the MS spectra and MS/MS spectra of the preliminarily obtained biomarkers, and identifying biomarkers related to pollutant exposure. The method of the present invention obviously improves the accuracy of biomarker screening, and improves the throughput of biomarker screening.

公开(公告)号：US20210318271A1

公开(公告)日：2021-10-14

申请号：US17262854

申请日：2019-07-26

申请人： INFICON GmbH

发明人： Johan Hellgren ,  Henrik Vennerberg

IPC分类号： G01N30/06 ,  G01N30/88

摘要： Method for adapting the concentration of a sample gas in a gas mixture to be analysed by a gas chromatograph assembly, the assembly comprising a sample gas inlet, a secondary gas inlet, a gas chromatograph sensor, a gas chromatograph column, and a gas chromatograph bypass parallel to the column, characterized by a) introducing sample gas through the sample gas inlet, b) introducing secondary gas through the secondary gas inlet, c) mixing the sample gas and the secondary gas to a gas mixture and conducting the mixture via the bypass, d) circulating the mixture in a gas conducting loop comprising the bypass and the sensor, e) repeating steps b), c) and d) without step a) to gradually reduce the concentration of sample gas within the mixture until the concentration reaches a desired predetermined level, f) analysing the mixture by means of gas chromatography employing the column and the sensor.

公开(公告)号：US11143633B2

公开(公告)日：2021-10-12

申请号：US15769215

申请日：2016-10-19

申请人： Waters Technologies Corporation

发明人： Abhijit Tarafder

IPC分类号： G01N30/06 ,  G01N30/20 ,  G01N30/88 ,  B01D15/12 ,  B01D15/14

摘要： A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line. In addition, by decoupling the injection system from the main solvent flow line, additional components (e.g., filters, valves, etc.) can be introduced into the chromatography system without increasing the negative band broadening effects. Systems and methods herein provide not only for such decoupling but also for filtering precipitates from the system. As a result, a larger volume of sample can be injected into the present systems without compromising separation yield. In addition, an increase the column loading per batch, an increase the overall yield of separations, and greater system efficiency (i.e., less time lost for cleaning and maintenance) can be realized.

公开(公告)号：US20210302394A1

公开(公告)日：2021-09-30

申请号：US17263146

申请日：2019-06-25

申请人： GUANGXI ZHUANG AUTONOMOUS REGION CENTER FOR DISEASE CONTROL AND PREVENTION

发明人： Yang TANG ,  Yanhua LIAO ,  Ping LIU ,  Ningsheng LEI ,  Chuan LIANG

IPC分类号： G01N30/06

摘要： A dispersive solid-phase extraction material, a preparation method therefor and an application thereof. The method comprises: weighing humic acid and washing it using water under ultrasonic bath, centrifuging to obtain a solid precipitate; resuspending the solid precipitate in acetone, heating and evaporating until the acetone has evaporated completely to then obtain a residue; taking and placing the residue in a Soxhlet extractor, and adding a cleaning solution; cleaning by heating and refluxing until the refluxed liquid is clear and colorless, and then heating is stopped; taking out the cleaned material; drying the material at 100° C. for 1.5-2.5 h, cooling for 0.5-1 h, and sieving through a 120 mesh sieve; collecting the material under the sieve to obtain the dispersive solid-phase extraction material. The dispersive solid-phase extraction material can simultaneously extract and purify aflatoxins in edible oils for their detection

公开(公告)号：US11092522B2

公开(公告)日：2021-08-17

申请号：US15899223

申请日：2018-02-19

申请人： Janusz Pawliszyn

发明人： Janusz Pawliszyn

IPC分类号： G01N1/40 ,  B01L9/00 ,  B01L3/00 ,  G01N1/10 ,  G01N30/72 ,  G01N1/14 ,  G01N30/06 ,  G01N33/18 ,  G01N30/86 ,  G01N30/02 ,  G01N30/00

摘要： The present invention describes several embodiments of a device that allows for the supporting, storage and deployment of large surface area thin film solid phase microextraction (TF-SPME) chemical samplers from within a sample fluid carrier. The utility of said supporting device originates from the process by which the extraction surface is stabilised within a sample carrying fluid for the extraction of chemical molecules from said sample carrying fluid. The device is also characterized by having a seating cavity, and moving mechanism or cap that can switch the supported TF-SPME chemical sampler between an open, sampling position or closed storage position.