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    System for osmotic delivery of pharmaceutically active agents
    53.
    发明申请
    System for osmotic delivery of pharmaceutically active agents 有权
    用于药物活性剂渗透递送的系统

    公开(公告)号：US20030003150A1

    公开(公告)日：2003-01-02

    申请号：US09872173

    申请日：2001-06-01

    Inventor： Beth A. Burnside ,  Henry H. Flanner ,  Lisa C. McKnight

    IPC: A61K009/24

    CPC classification number: A61K9/0004 ,  Y10S514/96 ,  Y10S514/964

    Abstract: An osmotic system for delivering a pharmaceutically active agent which comprises a core portion, a layer portion enclosing the core portion, and a semipermeable wall portion enclosing the core portion and the layer portion. The core portion includes the pharmaceutically active agent at a first concentration. The pharmaceutically active agent is present in the layer portion at a second concentration. The second concentration is greater than the first concentration. Such a system provides for the osmotic release of the pharmaceutically active agent in release profile other than a zero order release profile, and wherein the release profile is similar to or approaches or reaches a first order release profile.

    Abstract translation: 一种用于递送药物活性剂的渗透系统，其包含核心部分，封闭核心部分的层部分和封闭核心部分和层部分的半透壁部分。 核心部分包括处于第一浓度的药物活性剂。 药物活性剂以第二浓度存在于层部分中。 第二浓度大于第一浓度。 这样的系统提供药物活性剂在除零级释放曲线之外的释放特征中的渗透释放，并且其中释放特征与第一释放曲线相似或接近或达到一级释放曲线。

    Simple compression
    56.
    发明申请
    Simple compression 失效
    简单压缩

    公开(公告)号：US20020164370A1

    公开(公告)日：2002-11-07

    申请号：US09792932

    申请日：2001-02-27

    Inventor： Minh Van Nguyen

    IPC: A61K009/20 ,  B27N003/00

    CPC classification number: A61K9/2063 ,  Y10S514/96

    Abstract: The present invention comprises a method of tablet preparation. The invention provides a simple and cost effective method to compress good tablets.

    Abstract translation: 本发明包括片剂的制备方法。 本发明提供了一种压缩好片剂的简单且经济有效的方法。

    Means for creating a mass having structural integrity
    57.
    发明授权
    Means for creating a mass having structural integrity 有权
    用于创造具有结构完整性的物体的方法

    公开(公告)号：US06465010B1

    公开(公告)日：2002-10-15

    申请号：US09902751

    申请日：2001-07-12

    Applicant: Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    Inventor： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    IPC: A61K920

    CPC classification number: A61K9/0056 ,  A61K9/1623 ,  A61K9/1658 ,  A61K9/2081 ,  Y10S514/96 ,  Y10S514/961

    Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.

    Abstract translation: 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。

    Pharmaceutical formulation
    59.
    发明申请
    Pharmaceutical formulation 审中-公开
    药物制剂

    公开(公告)号：US20020114831A1

    公开(公告)日：2002-08-22

    申请号：US09788414

    申请日：2001-02-21

    Inventor： Inger Norden ,  Catarina Carling ,  Peter Fyhr

    IPC: A61K009/52 ,  A61K009/14

    CPC classification number: A61K31/64 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/4422 ,  A61K31/4468 ,  Y10S514/96

    Abstract: The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low solubility in water dispersed or dissolved in at least one erodable hydrophilic polymeric matrix.

    Abstract translation: 本发明涉及具有制剂表面的加速侵蚀和/或溶解速率的延长释放制剂。 该制剂包含在水中溶解度低的药物，其分散或溶解在至少一种可侵蚀的亲水性聚合物基质中。

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