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![Use of Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1](/abs-image/US/2009/07/09/US20090176851A1/abs.jpg.150x150.jpg)
51.发明申请Use of Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 审中-公开螺旋[咪唑烷-4,3' - 内酰胺] 2,2'，5'（1H）二恶烷用于治疗与香草素受体1相关的病症的用途公开(公告)号：US20090176851A1
公开(公告)日：2009-07-09
申请号：US12278657
申请日：2007-02-06
IPC分类号： A61K31/4188 , C07D487/10 , A61P25/00 , C07D209/38
CPC分类号： C07D487/10 , A61K31/4188
摘要： The present invention relates to a new use of spiro-hydantoin derivatives of formula (I), or salts, solvates or solvated salts thereof, as well as to new compounds, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译： 本发明涉及式（I）的螺 - 乙内酰脲衍生物或其盐，溶剂化物或溶剂化物的新用途，以及新化合物，其制备方法和用于其制备的新中间体，药物 含有所述治疗活性化合物的组合物和所述活性化合物在治疗中的用途。
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52.发明申请Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I 有权化合物，含有它们的组合物及其制备方法I公开(公告)号：US20060264490A1
公开(公告)日：2006-11-23
申请号：US11419603
申请日：2006-05-22
申请人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
发明人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184
CPC分类号： C07D235/08 , C07D235/10 , C07D405/06
摘要： Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， >，R 5和G如说明书中所定义，以及制备包括化合物在内的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US20060135554A1
公开(公告)日：2006-06-22
申请号：US11325124
申请日：2006-01-04
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D231/12 , C07D233/56 , C07D235/12 , C07D235/30 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/06 , C07D471/04
摘要： Compounds of general formula I are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译： 通式I的化合物在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在疼痛的治疗中的用途。
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公开(公告)号：US20050245503A1
公开(公告)日：2005-11-03
申请号：US10498864
申请日：2002-12-17
IPC分类号： C07D295/12 , A61K31/17 , A61K31/381 , A61K31/40 , A61K31/425 , A61K31/444 , A61K31/445 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/554 , A61P25/04 , C07C275/26 , C07C281/06 , C07D207/08 , C07D207/09 , C07D207/26 , C07D207/273 , C07D211/14 , C07D213/77 , C07D213/82 , C07D275/02 , C07D275/03 , C07D295/13 , C07D333/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/38 , A61K31/4184 , A61K31/473 , A61K31/4743 , A61K31/502
CPC分类号： C07D207/273 , C07D207/09 , C07D213/77 , C07D213/82 , C07D275/03 , C07D295/13 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： Compounds of formula (I) or (II) wherein R1, R2, R3, R4, W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）或（II）的化合物，其中R 1，R 2，R 3，R 4， ，W，Q，G，X和Y如说明书中所定义，以及其盐，对映异构体和包含该化合物的药物组合物。 它们可用于治疗，特别是治疗疼痛。
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55.发明申请Compounds, Compositions Containing Them, Preparation Thereof and Uses Thereof I 审中-公开化合物，含有它们的组合物及其制备方法I公开(公告)号：US20090221657A1
公开(公告)日：2009-09-03
申请号：US12466415
申请日：2009-05-15
申请人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
发明人： Daniel Page , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , A61P35/00 , A61P25/00 , A61P9/00 , A61P1/00
CPC分类号： C07D235/08 , C07D235/10 , C07D405/06
摘要： Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I的化合物或其药学上可接受的盐：其中R1，R2，R3，R4，R5和G如说明书中所定义，以及包括所述化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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56.发明授权公开(公告)号：US07501447B2
公开(公告)日：2009-03-10
申请号：US10557806
申请日：2004-06-09
申请人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/08 , C07D409/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
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57.发明申请Benzimidazole Derivatives,Compositions Containing Them, Preparation Thereof and Uses Thereof 审中-公开苯并咪唑衍生物，含有它们的组合物及其制备方法及用途公开(公告)号：US20080221178A1
公开(公告)日：2008-09-11
申请号：US10572825
申请日：2004-09-24
申请人： Ziping Liu , Claire Milburn , Daniel Page , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Claire Milburn , Daniel Page , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04 , A61P25/00 , A61P35/04 , A61P9/00 , A61P1/00
CPC分类号： C07D409/12 , C04B35/632 , C07D235/08 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3 and Ar are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）的化合物或其药学上可接受的盐; 其中R 1，R 2，R 3和Ar如说明书中所定义，以及盐和药物组合物，包括化合物的制备 。 它们可用于治疗，特别是治疗疼痛。
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58.发明申请Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof 有权苯并咪唑衍生物，含有它们的组合物及其制备方法及用途公开(公告)号：US20080207612A1
公开(公告)日：2008-08-28
申请号：US10573054
申请日：2004-09-24
申请人： Ziping Liu , Daniel Page , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Page , Christopher Walpole , Hua Yang
IPC分类号： A61K31/416 , C07D235/04 , C07D413/12 , A61K31/454 , A61P9/00 , A61P1/00 , A61P25/28 , C07D401/12 , A61K31/5377
CPC分类号： C07D215/18 , C07D215/38 , C07D235/14
摘要： Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）的化合物或其药学上可接受的盐; 其中R 1，R 2，R 3和R 4如说明书中所定义，以及 制备包括这些化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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59.发明申请Benzimidazole derivatives, compositions containing them, preparation therof and uses thereof 失效苯并咪唑衍生物，含有它们的组合物，制备方法及其用途公开(公告)号：US20070060583A1
公开(公告)日：2007-03-15
申请号：US10557813
申请日：2004-06-09
申请人： Ziping Liu , Daniel Page , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Page , Christopher Walpole , Hua Yang
IPC分类号： A61K31/5377 , A61K31/42 , A61K31/4184 , C07D413/02 , C07D405/02 , C07D261/02
CPC分类号： C07D235/08 , C07D401/06 , C07D405/06 , C07D413/06
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， SUB＆gt;和Z如说明书中所定义，以及盐和药物组合物包括化合物的制备。 它们可用于治疗，特别是治疗疼痛。
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60.发明申请Azaindole derivatives, preparations thereof, uses thereof and compositions containing them 失效Azaindole衍生物，其制剂，其用途和含有它们的组合物公开(公告)号：US20070027179A1
公开(公告)日：2007-02-01
申请号：US10550663
申请日：2004-03-26
申请人： Zhongyong Wei , Regis Dolaine , Christopher Walpole , Hua Yang
发明人： Zhongyong Wei , Regis Dolaine , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof Formula (I) wherein Ar, R1, R2, R3, Ra, Rb and X are as defined in the specificationas well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐式（I）其中Ar，R 1，R 2，R 3，R 3， 本说明书中定义，并且制备包括所述化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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