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公开(公告)号：US20110160180A1
公开(公告)日：2011-06-30
申请号：US12673617
申请日：2008-08-15
申请人： Sara Beha , William Brown , Shawn Johnstone , Ziping Liu , Daniel Pagé , Miroslaw Tomaszewski , Zhong-yong Wei , Shi Yi Yue
发明人： Sara Beha , William Brown , Shawn Johnstone , Ziping Liu , Daniel Pagé , Miroslaw Tomaszewski , Zhong-yong Wei , Shi Yi Yue
IPC分类号： A61K31/403 , C07D405/08 , C07D405/14 , A61K31/454 , A61P29/00 , A61P35/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/22 , A61P1/00 , A61P9/00
CPC分类号： C07D405/04 , C07D405/14
摘要： Compounds of Formulae (I), or pharmaceutically acceptable salts thereof: wherein R1, R2 and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）化合物或其药学上可接受的盐：其中R1，R2和Y如说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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2.发明授权公开(公告)号：US07501447B2
公开(公告)日：2009-03-10
申请号：US10557806
申请日：2004-06-09
申请人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/08 , C07D409/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
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3.发明授权Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof 失效苯并咪唑衍生物，含有它们的组合物，其制备及其用途公开(公告)号：US07517898B2
公开(公告)日：2009-04-14
申请号：US10557813
申请日：2004-06-09
申请人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/08 , C07D401/06 , C07D405/06 , C07D413/06
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）化合物或其药学上可接受的盐：其中R1，R2，R3，R4和Z如说明书中所定义，以及包括该化合物的盐和药物组合物的制备。 它们可用于治疗，特别是治疗疼痛。
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4.发明授权4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain of gastrointestinal disorders 失效4（苯基 - 哌嗪基 - 甲基）苯甲酰胺衍生物及其用于治疗胃肠道疾病的疼痛的用途公开(公告)号：US07253173B2
公开(公告)日：2007-08-07
申请号：US10533654
申请日：2003-11-05
申请人： William Brown , Andrew Griffin , Paul Jones , Daniel Pagé , Niklas Plobeck , Christopher Walpole
发明人： William Brown , Andrew Griffin , Paul Jones , Daniel Pagé , Niklas Plobeck , Christopher Walpole
IPC分类号： C07D24/04 , A61K31/4965 , A61K31/497 , A61P25/04
CPC分类号： C07D213/38 , C07D215/12 , C07D233/64 , C07D277/28 , C07D295/155 , C07D307/52 , C07D333/20
摘要： Compounds of general formula (I) wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain
摘要翻译： 其中R 1，R 2和R 3的通式（I）的化合物如说明书中所定义，以及盐，对映异构体 并且制备包含该化合物的药物组合物。 它们可用于治疗，特别是治疗疼痛
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5.发明授权Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof 有权苯并咪唑衍生物，含有它们的组合物，其制备及其用途公开(公告)号：US08633235B2
公开(公告)日：2014-01-21
申请号：US10573054
申请日：2004-09-24
申请人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Ziping Liu , Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D215/18 , C07D215/38 , C07D235/14
摘要： Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式（I）的化合物或其药学上可接受的盐; 其中R1，R2，R3和R4如说明书中所定义，以及盐和药物组合物，包括该化合物的制备。 它们可用于治疗，特别是治疗疼痛。
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6.发明授权Compounds, compositions containing them, preparation thereof and uses thereof I 有权化合物，含有它们的组合物，其制备方法及用途I公开(公告)号：US07550495B2
公开(公告)日：2009-06-23
申请号：US11419603
申请日：2006-05-22
申请人： Daniel Pagé , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
发明人： Daniel Pagé , Ziping Liu , Maxime Tremblay , Christopher Walpole , Hua Yang
IPC分类号： A61K31/415 , C07D235/08
CPC分类号： C07D235/08 , C07D235/10 , C07D405/06
摘要： Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, R5, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
摘要翻译： 式I化合物或其药学上可接受的盐：其中R1，R2，R3，R4，R5和G如说明书中所定义，以及包括所述化合物的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛。
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公开(公告)号：US07407968B2
公开(公告)日：2008-08-05
申请号：US10530499
申请日：2003-10-15
申请人： Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A01N43/52 , A01N43/42 , A61K31/415 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D235/00
CPC分类号： C07D235/12 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14
摘要： Compounds of formula (I) wherein RF1, RF2, Z, R1, R2, Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain.
摘要翻译： R 1，R 2，Z，R 1，R 2，R 2，R 2，R 2，R 2， ，X和Y如说明书中所定义，以及制备包括这些化合物在内的盐和药物组合物。 这些化合物可用于治疗，特别是治疗疼痛。
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8.发明申请公开(公告)号：US20060205802A1
公开(公告)日：2006-09-14
申请号：US10557806
申请日：2004-06-09
申请人： Zipingé Liu , Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Zipingé Liu , Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/04 , C07D403/02
CPC分类号： C07D235/08 , C07D409/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
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9.发明授权Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof 失效苯并咪唑衍生物，含有它们的组合物，其制备及其用途公开(公告)号：US07244850B2
公开(公告)日：2007-07-17
申请号：US10559887
申请日：2004-06-09
申请人： Daniel Pagé , Christopher Walpole , Hua Yang
发明人： Daniel Pagé , Christopher Walpole , Hua Yang
IPC分类号： A61K31/4184 , C07D235/08
CPC分类号： C07D235/08
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R1, R2, RF1, RF2 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain
摘要翻译： 式（I）化合物或其药学上可接受的盐：式（I）其中R 1，R 2，RF 1，RF 0 > 2和Z如说明书中所定义，以及制备包括化合物在内的盐和药物组合物。 它们可用于治疗，特别是治疗疼痛
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