公开(公告)号：US20180106809A1

公开(公告)日：2018-04-19

申请号：US15849962

申请日：2017-12-21

Applicant: Genentech, Inc.

Inventor： Mark S. Dennis ,  Bonnee Rubinfeld ,  Paul Polakis ,  Aya Jakobovits

IPC: G01N33/574 ,  A61K47/68 ,  A61K49/00

CPC classification number: G01N33/57434 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K47/6869 ,  A61K47/6871 ,  A61K49/0002 ,  A61K49/0058 ,  A61K51/1045 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K16/40 ,  C07K17/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.

公开(公告)号：US20170166635A1

公开(公告)日：2017-06-15

申请号：US15346532

申请日：2016-11-08

Applicant: GENENTECH, INC.

Inventor： Weiguang Mao ,  Jagath Reddy Junutula ,  Paul Polakis

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K38/05 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6869 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/77 ,  G01N33/574 ,  G01N33/57492

Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p   (I) where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.

公开(公告)号：US09597411B2

公开(公告)日：2017-03-21

申请号：US14705525

申请日：2015-05-06

Applicant: GENENTECH, INC.

Inventor： Youjun Chen ,  William Mallet ,  Paul Polakis ,  Christine Tan ,  Jyoti Asundi ,  Suzanna Clark

IPC: A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  A61K51/10 ,  C07K16/30 ,  G01N33/60 ,  C07K16/28

CPC classification number: C07K16/3053 ,  A61K31/5383 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6889 ,  A61K51/1093 ,  C07K16/2854 ,  C07K16/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/77 ,  G01N33/58 ,  G01N33/60

Abstract: The invention provides anti-PMEL17 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US09593167B2

公开(公告)日：2017-03-14

申请号：US14517682

申请日：2014-10-17

Applicant: Genentech, Inc.

Inventor： Mark S. Dennis ,  Bonnee Rubinfeld ,  Paul Polakis ,  Aya Jakobovits

IPC: C07K16/00 ,  C07K16/40 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C07K16/30 ,  A61K38/05 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: G01N33/57434 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K47/6869 ,  A61K47/6871 ,  A61K49/0002 ,  A61K49/0058 ,  A61K51/1045 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K16/40 ,  C07K17/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.

Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。

公开(公告)号：US20140128580A1

公开(公告)日：2014-05-08

申请号：US14149979

申请日：2014-01-08

Applicant: Genentech, Inc.

Inventor： Allen J. Ebens, JR. ,  Frederic S. Jacobson ,  Paul Polakis ,  Ralph H. Schwall ,  Mark X. Sliwkowski ,  Susan D. Spencer

IPC: A61K47/48

CPC classification number: A61K47/6803 ,  A61K47/6875 ,  A61K2039/505 ,  C07D498/18 ,  C07K16/1063 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/24

Abstract: The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p  I where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.

Abstract translation: 本发明涉及式I的抗体 - 药物偶联化合物：Ab-（LD）p I，其中一种或多种美登木素生物碱药物部分（D）通过L共价连接到结合ErbB受体的抗体（Ab），或 其结合一种或多种肿瘤相关抗原或细胞表面受体。 这些化合物可用于诊断或治疗癌症及其它疾病和病症的方法中。

公开(公告)号：US12281165B2

公开(公告)日：2025-04-22

申请号：US17677283

申请日：2022-02-22

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US12134649B2

公开(公告)日：2024-11-05

申请号：US17547528

申请日：2021-12-10

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K38/08 ,  A61K39/395 ,  A61K47/65 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  G01N33/569 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20180251567A1

公开(公告)日：2018-09-06

申请号：US15983361

申请日：2018-05-18

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Bonnee Rubinfeld ,  Paul Polakis

IPC: C07K16/30 ,  G01N33/574 ,  A61K47/68 ,  A61K31/537 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K31/537 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3023 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57492

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US09994643B2

公开(公告)日：2018-06-12

申请号：US15341261

申请日：2016-11-02

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Bonnee Rubinfeld ,  Paul Polakis

IPC: C07K16/30 ,  A61K47/48 ,  C07K16/28 ,  G01N33/574 ,  A61K45/06 ,  C07K16/18 ,  A61K31/537 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K31/537 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3023 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57492

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20170290920A1

公开(公告)日：2017-10-12

申请号：US15497656

申请日：2017-04-26

Applicant: MEDIMMUNE LIMITED ,  GENENTECH, INC.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  John A. Flygare ,  Janet L. Gunzner-Toste ,  Thomas H. Pillow ,  Philip Wilson Howard ,  Luke Masterson

IPC: A61K47/48 ,  A61K31/5517 ,  C07D487/16 ,  C07K19/00

CPC classification number: A61K31/5517 ,  A61K31/551 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  A61K47/6877 ,  A61K2300/00

Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.