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51.发明申请公开(公告)号：US20210023209A1
公开(公告)日：2021-01-28
申请号：US16981462
申请日：2019-03-15
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
发明人： Roberto MALLONE , Yann VERDIER , Joëlle VINH , Marie-Eliane AZOURY , Sergio GONZALEZ-DUQUE , Georgia AFONSO
IPC分类号： A61K39/395 , C07K14/47 , C07K14/725 , C12N15/115 , C12N15/62
摘要： Despite the notion that human CD8+ T cells are the final mediators of autoimmune β-cell destruction in type 1 diabetes (T1D), none of their target epitopes has been demonstrated to be naturally processed and presented by β cells. The inventors therefore performed an epitope discovery study combining HLA Class I peptidomics and transcriptomics strategies. Inflammatory cytokines increased β-cell peptide presentation in vitro, paralleling upregulation of HLA Class I expression. Peptide sources included known β-cell antigens and several insulin granule proteins. PCSK2 was identified as a novel β-cell antigen, which was processed into HLA-A2-restricted epitopes recognized by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors. Accordingly, the present invention relates to antigenic peptides derived from PCSK2 and uses thereof for the diagnosis and treatment of T1D.
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公开(公告)号：US10889715B2
公开(公告)日：2021-01-12
申请号：US16093313
申请日：2017-04-18
申请人： ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C08L83/08 , C08K5/07 , C08L83/06 , C08G77/38 , C08G77/382 , C08L83/00 , C08G77/388 , C08G77/14 , C08G77/26 , C08K5/16 , C08K5/18 , C08J3/24 , C08K5/17 , C08K5/29
摘要： The invention relates to a silicone composition comprising (a) crosslinked polymers comprising consecutive —Si—O— units containing exchangeable pendant bonds and exchangeable crosslinking points, that are exchangeable by aldehyde-imine exchange reactions and/or by imine-imine exchange reactions and/or by imine-primary amine exchange reactions, obtained by crosslinking linear or branched polymers comprising consecutive —Si—O— units and (b) monofunctional free aldehydes and/or monofunctional free imines and/or monofunctional free primary amines.
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公开(公告)号：US20200337569A1
公开(公告)日：2020-10-29
申请号：US16958882
申请日：2018-04-18
申请人： RHODIA OPERATIONS , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Mathieu TAUBAN , Mickaël PRUVOST , Annie COLIN , Philippe POULIN , Lise TROUILLET-FONTI , Olivier SANSEAU
IPC分类号： A61B5/021 , A61B5/02 , A61B5/00 , C08J9/28 , C08J5/18 , C08J9/00 , B32B5/18 , B32B27/06 , B32B27/36 , G01L1/14
摘要： Pressure sensing layers, devices comprising same, pressure sensing monitors and composite materials comprising a) a porous matrix material comprising a siloxane polymer, comprising a closed porosity volume fraction, and, optionally, an open porosity volume fraction, and b) a conductive or semiconductive filler substantially present in said closed porosity volume fraction of said porous matrix material a), and films, coated substrates and multilayer structures comprising the composite material and the use thereof in pressure sensing devices.
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54.发明申请公开(公告)号：US20200231605A1
公开(公告)日：2020-07-23
申请号：US16306411
申请日：2017-05-30
申请人： ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Ludwik LEIBLER , Renaud NICOLAY
摘要： The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R′3 or R4 is a radical of formula —X; or one of R1, R2, R3, R′3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
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公开(公告)号：US10653387B2
公开(公告)日：2020-05-19
申请号：US15323305
申请日：2015-06-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , Université Pierre et Marie Curie (Paris 6) , Université Paris Diderot—Paris 7
摘要： Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (IVO), (b) the vascular image to be studied (IVO) is compared automatically, by shape recognition, with a cerebral vascular atlas (AV), and the vascular image to be studied (IVO) is thus located in the cerebral vascular atlas (AV), (c) a cerebral functional atlas (AF) corresponding to said cerebral vascular atlas (AV) and comprising cerebral functional zones (1c) located in this cerebral vascular atlas (AV) is used in such a way as to identify cerebral functional zones (1e) on the vascular image to be studied (IVO).
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公开(公告)号：US10508250B2
公开(公告)日：2019-12-17
申请号：US15543100
申请日：2016-01-11
申请人： TOTAL MARKETING SERVICES , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (ESPCI) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS)
IPC分类号： C10M155/04 , C10M169/04 , C10M161/00 , C10M105/00 , C10M129/08
摘要： The present disclosure relates to novel compositions of additives that result from mixing at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. A lubricant composition results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. The present disclosure also relates to a process for modulating the viscosity of a lubricant composition that results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers; as well as the use of a diol compound for modulating the viscosity of a lubricant composition.
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公开(公告)号：US10329414B2
公开(公告)日：2019-06-25
申请号：US15988895
申请日：2018-05-24
发明人： Ludwik Leibler , Renaud Nicolay , Max Rottger
IPC分类号： C08K5/00 , C08L33/14 , C09D7/65 , C08F220/14 , C08F230/06 , C08K5/55 , C08L43/00 , C08F210/02 , C08F212/08 , C08F220/28 , C08F220/30 , C08F220/16 , C08J3/24
摘要： The object of the invention is polymer compositions comprising cross-linked polymer comprising boronic ester functions enabling exchange reactions, as well as free monofunctional boronic esters. The compositions are obtained from the modification of a polymer by a functionalized boronic ester additive. This polymer can be pre-functionalized boronic ester or functionalized on addition of the said additive. In particular, the invention relates to a process enabling the behavior of a polymer to be modified by addition of a functional additive, enabling a cross-linked network containing exchangeable boronic ester links to be formed.
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公开(公告)号：US10011711B2
公开(公告)日：2018-07-03
申请号：US15243621
申请日：2016-08-22
发明人： Ludwik Leibler , Renaud Nicolay , Max Rottger
IPC分类号： C08L43/00 , C08J3/24 , C08K5/55 , C08L33/14 , C09D7/65 , C08F220/14 , C08F230/06 , C08F210/02 , C08F212/08 , C08F220/28 , C08F220/30 , C08F220/16
摘要： The object of the invention is a polymer composition including cross-linked polymers, which contain boronic ester functions enabling exchange reactions, as well as free monofunctional boronic esters. This composition originates from the polymerization of precursor monomers to thermoplastic polymers including at least one pending boronic ester group, the pending boronic ester group not containing any polymerizable groups, and cross-linking agent comprising at least one boronic ester group. This enables the formation of a network of cross-linked polymers containing pending functions and cross-links that are exchangeable by boronic ester metathesis reactions. Another object of the invention is processes for preparing this composition and materials and formulations comprising this composition.
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59.发明申请公开(公告)号：US20180023028A1
公开(公告)日：2018-01-25
申请号：US15543100
申请日：2016-01-11
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS) , TOTAL MARKETING SERVICES , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (ESPCI)
IPC分类号： C10M169/04 , C10M105/00 , C10M161/00 , C10M155/04 , C10M129/08
摘要： The present disclosure relates to novel compositions of additives that result from mixing at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. A lubricant composition results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers and at least one compound for controlling the association of these two copolymers. The present disclosure also relates to a process for modulating the viscosity of a lubricant composition that results from mixing at least one lubricating base oil, at least two thermoassociative and exchangeable copolymers; as well as the use of a diol compound for modulating the viscosity of a lubricant composition.
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60.发明申请公开(公告)号：US20180009912A1
公开(公告)日：2018-01-11
申请号：US15660349
申请日：2017-07-26
申请人： ARKEMA FRANCE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS (ESPCI)
CPC分类号： C08F4/48 , C08F4/461 , C08F4/50 , C08G59/245 , C08G59/68 , C08G59/685 , C08K3/01 , C08K5/0008
摘要： The invention relates to a composition containing at least one catalyst (C1) containing at least one atom of an element (M1) chosen from: Al, Sc, Ti, Mg, Mn, Fe, Co, Ni, Cu, Zn, Zr, Sn, Hf, Pb, Si, Sb and In; a catalyst (C2) comprising at least one atom of an element (M2) chosen from alkali metals and alkaline-earth metals; a thermosetting resin and/or a hardener for a thermosetting resin. The invention also relates to the use of this composition for rendering a resin which is in the thermoset state hot-deformable and nevertheless free of any residual stress after the deformation thereof; such a resin will advantageously retain its shape even if it is subsequently subjected to high temperatures. The invention relates, moreover, to kits for preparing the composition, to a thermoset-resin-based object obtained from a composition of the invention, to a process for manufacturing objects, to a process for hot-deformation of objects and to various possible uses of the compositions and objects of the invention.
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