公开(公告)号：US07284410B2

公开(公告)日：2007-10-23

申请号：US11169935

申请日：2005-06-29

申请人： Andrew Tipler ,  Heidi Grecsek ,  Frank DeLorenzo ,  Giuseppe Coppola

发明人： Andrew Tipler ,  Heidi Grecsek ,  Frank DeLorenzo ,  Giuseppe Coppola

IPC分类号： G01N30/04

CPC分类号： G01N30/12 ,  G01N30/16 ,  G01N30/32 ,  G01N2030/0015 ,  G01N2030/128 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a thermal desorption unit, a chromatographic column, and an interface device between the unit and the column. The interface device controls the fluid flowing into the column, such as by providing additional carrier gas to maintain a substantially constant gas flow or velocity, by proving a controlled temperature increase, or by venting a portion of the gas received from the thermal desorption unit, thereby removing the dependence on the thermal desorption unit for such control. In some embodiments, the interface is a chromatographic injector. In certain embodiments, a transfer line from the desorption unit is coupled to the same port of the interface device as the chromatographic column. In some of these embodiments, this is accomplished by employing a special adaptor.

摘要翻译： 公开了包括热解吸单元，色谱柱和单元和柱之间的界面装置的系统和方法。 接口装置控制流入柱的流体，例如通过提供额外的载气来维持基本恒定的气流或速度，通过证明控制的温度升高，或通过排出从热解吸单元接收的气体的一部分， 从而消除了对这种控制的热解吸单元的依赖性。 在一些实施方案中，界面是色谱注射器。 在某些实施方案中，来自解吸单元的传输线连接到与色谱柱相同的接口装置的端口。 在这些实施例中的一些实施例中，这通过采用特殊适配器来实现。

公开(公告)号：US20060099718A1

公开(公告)日：2006-05-11

申请号：US11251310

申请日：2005-10-14

申请人： Andrew Tipler ,  Christopher Mazza

发明人： Andrew Tipler ,  Christopher Mazza

IPC分类号： G01N1/10

CPC分类号： G01N1/2226 ,  G01N30/06 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/25875 ,  G01N30/32 ,  G01N2030/405

摘要： A system and method for extracting headspace vapor is generally disclosed comprising pressurizing a vessel containing headspace vapor with a carrier gas and subsequently venting the sample mixture through an adsorbent trap and out a vent. A flow controller is employed to gradually increase the flow therethrough as the pressure drops as a result of the gradual depletion of headspace vapor in the vessel and, in certain embodiments, the flow controller maintains a constant flow rate. Due to the time saved, in some embodiments, multiple pressurization-venting cycles are implemented to maximize the amount of vapor extracted from the vial. Due to the constant flow rate, in certain embodiments, the pressure decay is monitored and compared to reference values in order to determine whether the sample vessel has a leak or other defect.

摘要翻译： 通常公开了一种用于提取顶空蒸气的系统和方法，包括用载气加压含有顶空蒸气的容器，随后将样品混合物通过吸附剂阱并排出出口。 采用流量控制器随着压力下降而逐渐增加流量，这是由于容器中顶部空气蒸气逐渐消耗的结果，并且在某些实施例中，流量控制器保持恒定的流速。 由于节省了时间，在一些实施例中，实施多个加压 - 排气循环以最大化从小瓶中提取的蒸气的量。 由于恒定的流速，在某些实施例中，监测压力衰减并与参考值进行比较，以确定样品容器是否具有泄漏或其他缺陷。

公开(公告)号：US07013707B2

公开(公告)日：2006-03-21

申请号：US10345608

申请日：2003-01-16

申请人： Otto J. Prohaska ,  Avinash Dalmia ,  Andrew Tipler

发明人： Otto J. Prohaska ,  Avinash Dalmia ,  Andrew Tipler

IPC分类号： G01N27/26 ,  G01N27/407 ,  G01N30/62

CPC分类号： G01N30/62 ,  G01N27/4045 ,  G01N30/64 ,  G01N2030/025 ,  G01N2030/125 ,  G01N2030/645

摘要： The invention includes a method and apparatus for a chromatography system having a chromatographic column for separating gases in a mixture from one another and an electrochemical gas sensor coupled to the chromatographic column for detecting a gas being emitted from the column. The electrochemical gas sensor further includes a substrate having a surface for depositing electrodes thereon, an ionomer membrane in contact with the surface, an electrode in contact with the surface, and an opening in the ionomer membrane in a location proximate to the electrode for permitting a gas to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening.

公开(公告)号：US20060016245A1

公开(公告)日：2006-01-26

申请号：US11189467

申请日：2005-07-26

申请人： Andrew Tipler ,  Richard Edwards

发明人： Andrew Tipler ,  Richard Edwards

IPC分类号： G01N30/04

CPC分类号： G01N30/32 ,  G01N30/461 ,  G01N30/8693 ,  G01N2030/324

摘要： Disclosed are systems and methods that include a sampling device, a chromatographic column, and a transfer line through which a fluid containing analytes to be measured are communicated from the sampling device to the column. The pressure at which the fluid containing the analytes is applied at the inlet of the transfer line is adjusted as the temperature of the column increases in accordance with certain relationships in order to maintain a substantially constant flow rate or velocity for the fluid exiting the column. In this way, the system compensates for changes in the viscosity of the fluid flowing through the column that result from changes in the column temperature.

摘要翻译： 公开了包括采样装置，色谱柱和传输线的系统和方法，含有待测量待分析物的流体通过该传输线从采样装置传送到塔。 随着塔的温度根据某些关系而增加包含分析物的流体在输送管线的入口处的压力，以便为离开塔的流体保持基本恒定的流速或速度。 以这种方式，该系统补偿由柱温变化引起的流经塔的流体的粘度变化。

公开(公告)号：US20050039602A1

公开(公告)日：2005-02-24

申请号：US10954784

申请日：2004-09-30

申请人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

发明人： Andrew Tipler ,  Gary Campbell ,  Mark Collins

IPC分类号： G01N1/22 ,  G01N30/12 ,  B01D53/02

CPC分类号： B01D53/025 ,  B01D2253/102 ,  G01N30/12 ,  G01N2001/2229 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/127 ,  G01N2030/128

摘要： An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.

摘要翻译： 公开了用于气相色谱的分析物预浓缩器，其通常包括具有限制出口并装有吸附剂的管，其中管用作色谱注射器的衬垫，作为与色谱柱耦合的吸附阱，和/或 耦合到顶空采样器的吸附阱。 优选地，加热装置允许管被加热。 在优选实施方案中，分析物预浓缩器还包括柱分离附件，使得色谱柱可以暂时与流过管的物质隔离。

公开(公告)号：US06645773B2

公开(公告)日：2003-11-11

申请号：US10079712

申请日：2002-02-20

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01M1100

CPC分类号： G01K11/00 ,  G01K11/02 ,  Y10T436/25875

摘要： A method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.

摘要翻译： 提供一种测量具有顶部空间的密封容器内的有效温度的方法。 将液体溶剂加入到容器中，并将固体化合物加入到液体溶剂中以产生饱和溶液。 允许饱和溶液的蒸气在密封容器的顶部空间中平衡，并将其体积转移到色谱柱，其中取平衡蒸气的色谱读数。 然后基于平衡蒸气的色谱读数计算密封容器内的温度，其中温度计算基于平衡蒸气中的液体溶剂和固体化合物的浓度。

公开(公告)号：US10247710B2

公开(公告)日：2019-04-02

申请号：US14058329

申请日：2013-10-21

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/40 ,  G01N30/32 ,  G01N30/46 ,  G01N30/60 ,  G01N30/44

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample.

公开(公告)号：US08794053B2

公开(公告)日：2014-08-05

申请号：US13158953

申请日：2011-06-13

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N1/00

CPC分类号： B01D53/0446 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/62 ,  G01N30/72 ,  G01N2030/328 ,  Y10T137/877

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.

摘要翻译： 本文描述的某些实施例涉及包括配置成在三个或更多个输入或输出之间提供三路切换或切换的微流体装置的色谱系统。 微流体装置可以流体耦合到一个或多个切换阀，以提供色谱系统中流体流动的选择性控制。

公开(公告)号：US08561484B2

公开(公告)日：2013-10-22

申请号：US12729432

申请日：2010-03-23

申请人： Andrew Tipler ,  Avinash Dalmia

发明人： Andrew Tipler ,  Avinash Dalmia

IPC分类号： G01N1/22 ,  G01N1/40 ,  G01N25/00 ,  G01N30/54 ,  G01N30/60

CPC分类号： G01N1/2214 ,  G01N1/2294 ,  G01N1/405

摘要： Certain aspects and examples are directed to sorbent devices and methods of using them. In certain embodiments, a sorbent device comprising a body comprising a sampling inlet, a base and a longitudinal diffusion path between the inlet and the base is provided. In some embodiments, the sorbent device can include at least two sorbent materials fluidically coupled to the longitudinal diffusion path, in which the sorbent materials are arranged from a material with a weakest sorbent strength to a material with a strongest sorbent strength with the weakest sorbent strength material adjacent to the sampling inlet.

摘要翻译： 某些方面和实例涉及吸附剂装置和使用它们的方法。 在某些实施方案中，提供了一种吸附剂装置，其包括在入口和底部之间包括取样入口，基部和纵向扩散路径的主体。 在一些实施方案中，吸附剂装置可以包括至少两种与纵向扩散路径流体连接的吸附剂材料，其中吸附剂材料从具有最弱吸附剂强度的材料排列成具有最强吸附剂强度的材料，其吸附剂强度最弱 与采样入口相邻的材料。

公开(公告)号：US20130220001A1

公开(公告)日：2013-08-29

申请号：US13657079

申请日：2012-10-22

申请人： Andrew Tipler

发明人： Andrew Tipler

IPC分类号： G01N30/28

CPC分类号： G01N30/32 ,  G01N30/20 ,  G01N30/28 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7206 ,  G01N2030/208 ,  G01N2030/324 ,  G01N2030/328 ,  Y10T29/49 ,  Y10T137/0318

摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device. The microfluidic device can be fluidically coupled to a switching valve to provide for selective control of fluid flow in the chromatography system. In some examples, the microfluidic device may include a charging chamber, a bypass restrictor or other features that can provide for added control of the fluid flow in the system. Methods of using the devices and methods of calculating lengths and diameters to provide a desired flow rate are also described.