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    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
    54.
    发明授权
    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device 有权

    公开(公告)号：US10888517B2

    公开(公告)日：2021-01-12

    申请号：US16514967

    申请日：2019-07-17

    Applicant: Rani Therapeutics, LLC

    Inventor： Mir Imran

    IPC: A61K9/48 ,  A61K9/00 ,  A61M25/10 ,  A61M5/00 ,  A61K38/29 ,  A61K31/155 ,  A61M31/00 ,  A61M37/00

    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

    Systems and methods for processing sonified brain signals
    56.
    发明授权
    Systems and methods for processing sonified brain signals 有权

    公开(公告)号：US10849553B2

    公开(公告)日：2020-12-01

    申请号：US16367040

    申请日：2019-03-27

    Applicant: CeriBell, Inc.

    Inventor： Alexander Grant ,  Chris Chafe ,  Josef Parvizi ,  Jianchun Yi ,  Raymond Woo ,  Xingjuan Chao

    IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0402 ,  G10L25/51 ,  A61B5/0488 ,  A61B5/0496 ,  H04R3/04 ,  A61B5/0476

    Abstract: Systems and methods for sonifying electrical signals obtained from a living subject, particularly EEG signals, are disclosed. A time-domain signal representing the activity of an organ is obtained. A voltage of the time-domain signal over a time block is determined. An acoustic signal based on the time-domain signal over the time block is produced. The acoustic signal comprises one or more audibly discernible variations representative of the activity of the organ. If the determined voltage is over a threshold voltage, the time-domain signal is squelched over at least a portion of the time-block as the acoustic signal is produced. The time-domain signal can be squelched by ramping down the signal as an input to produce the acoustic signal. The frequency spectrum of the acoustic signal can also be adjusted as it is produced, such as by flattening the signal and/or attenuating high frequencies along the frequency spectrum of the signal.

    Apparatus and method for self-guided ablation
    59.
    发明授权
    Apparatus and method for self-guided ablation 有权

    公开(公告)号：US10568688B2

    公开(公告)日：2020-02-25

    申请号：US16018526

    申请日：2018-06-26

    Applicant: Perceptive Ablation, Inc.

    Inventor： Bob Sueh-Chien Hu ,  Girish Ananth Narayan ,  Byongho Park

    IPC: A61B18/14 ,  A61B18/02 ,  A61M25/01 ,  A61B18/00 ,  A61B34/20 ,  A61B90/00

    Abstract: An ablation catheter comprises an elongate catheter body and a branch electrode element. The elongate catheter body has a central axis, a distal end, and a proximal end. The elongate catheter body is configured to be steered within a heart chamber. The branch electrode element has a base end and a working end or tip. The base end is secured to the elongate catheter body at a location spaced proximally of the distal end and an effector on the working end. The branch electrode element is configured to evert when the distal end of the elongate catheter body is in a pulmonary vein ostium or os so that the effector can be selectively engaged against locations surrounding the pulmonary vein os which differ in radial direction and distance. One or more of linear or curved ablation patterns are generated on tissue adjacent the pulmonary vein os with the effector.

    Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins
    60.
    发明授权
    Pharmaceutical compositions and methods for fabrication of solid masses comprising glucose regulating proteins 有权

    公开(公告)号：US10220076B2

    公开(公告)日：2019-03-05

    申请号：US14714146

    申请日：2015-05-15

    Applicant: InCube Labs, LLC

    Inventor： Mercedes Morales ,  Mir Imran ,  Radhika Korupolu ,  Mir Hashim

    IPC: A61K38/28 ,  C07K16/24 ,  A61K9/20 ,  A61K38/26 ,  C07K16/00

    Abstract: Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.

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