公开(公告)号：US20240110191A1

公开(公告)日：2024-04-04

申请号：US18265002

申请日：2021-12-02

申请人： Synlogic Operating Company, Inc.

发明人： Michael James ,  Aida Kalantari ,  Tea Mirabella ,  Lauren Renaud ,  Lee Kristensen ,  Vincent Isabella

IPC分类号： C12N15/52 ,  C07K14/245

CPC分类号： C12N15/52 ,  C07K14/245 ,  C12R2001/19

摘要： The present invention relates to engineered microorganisms, wherein the engineered microorganisms comprise a therapeutic molecule and a modified pks island.

公开(公告)号：US11944676B2

公开(公告)日：2024-04-02

申请号：US16637612

申请日：2018-08-07

申请人： Pebble Labs Inc.

发明人： Richard Sayre ,  Tatiana Vinogradova-Shah ,  Elena Sineva

IPC分类号： A61K39/02 ,  A01N63/60 ,  A23K10/16 ,  A23K50/80 ,  A61K35/741 ,  C12N15/113 ,  C12N15/52 ,  C12N15/63

CPC分类号： A61K39/107 ,  A01N63/60 ,  A23K10/16 ,  A23K50/80 ,  A61K35/741 ,  C12N15/113 ,  C12N15/52 ,  C12N15/63 ,  C12N2310/11

摘要： Generally, the inventive technology relates to novel strategies for disease control in animal systems. Specifically, the inventive technology relates to novel methods, systems and compositions for the biocontrol of pathogens in aquatic systems. Specifically, the invention may comprise novel techniques, systems, and methods for the biocontrol of disease-transmitting pathogens affecting shrimp in aquaculture systems.

公开(公告)号：US20240102061A1

公开(公告)日：2024-03-28

申请号：US18253585

申请日：2021-11-18

申请人： ANTHEIA, INC.

发明人： Christina D. SMOLKE ,  Catherine THODLEY ,  KRISTY M. HAWKINS ,  Kenneth TAKEOKA ,  Douglas HANSEN

IPC分类号： C12P17/12 ,  C12N9/88 ,  C12N15/52

CPC分类号： C12P17/12 ,  C12N9/88 ,  C12N15/52 ,  C12Y402/01078

摘要： Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoclaurine synthase increases conversion, within the engineered microbial cell, in comparison to a non-engineered norcoclaurine synthase.

公开(公告)号：US11939614B2

公开(公告)日：2024-03-26

申请号：US17691933

申请日：2022-03-10

申请人： National Research Council of Canada ,  University of Saskatchewan

发明人： Jonathan E. Page ,  Steve Gagne

IPC分类号： C12N15/82 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22 ,  C12P17/06

CPC分类号： C12P17/06 ,  C12N15/52 ,  C12N15/70 ,  C12P7/22 ,  C12Y404/01026

摘要： Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.

公开(公告)号：US11939584B2

公开(公告)日：2024-03-26

申请号：US17444188

申请日：2021-07-31

申请人： PRECIGEN, INC.

发明人： Xinhua Zhao ,  Mark Anton Held ,  Tina Huynh ,  Lily Yuin Chao ,  Na Trinh ,  Matthias Helmut Schmalisch ,  Bryan Yeh ,  James Kealey ,  Kevin Lee Dietzel

IPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N15/74 ,  C12P5/02 ,  C12P7/16 ,  C12P7/18

CPC分类号： C12N15/52 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/1022 ,  C12N9/88 ,  C12N15/74 ,  C12P5/023 ,  C12P7/16 ,  C12P7/18 ,  C12Y101/01304 ,  C12Y202/01006 ,  C12Y401/01004 ,  C12Y401/01005

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US11939583B2

公开(公告)日：2024-03-26

申请号：US17047974

申请日：2019-04-15

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Lennart Schada Von Borzyskowski ,  Tobias Jürgen Erb ,  Jan Zarzycki

IPC分类号： C12N15/52 ,  C12N1/21 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88 ,  C12N15/74

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0022 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12N15/74 ,  C12Y101/01026 ,  C12Y104/03016 ,  C12Y206/01001 ,  C12Y301/03018 ,  C12Y401/03014 ,  C12Y403/0102

摘要： The present invention relates to autotrophic microorganisms with altered photorespiration and improved CO2 fixation as well as a method of producing said autotrophic microorganisms. Particularly, the autotrophic microorganisms show an improved growth rate, productivity and energy conversion efficiency.

公开(公告)号：US20240093126A9

公开(公告)日：2024-03-21

申请号：US17735222

申请日：2022-05-03

申请人： The Procter & Gamble Company

发明人： Lars BEIER ,  Lars Henrik OESTERGAARD ,  Annette Helle JOHANSEN ,  Klaus GORI ,  Thomas Holberg BLICHER ,  Gernot J. ABEL ,  Steen KROGSGAARD ,  Jens E NIELSEN ,  Lars GIGER ,  Neil Joseph LANT

IPC分类号： C11D3/386 ,  C11D3/00 ,  C11D3/48 ,  C11D11/00 ,  C12N9/22 ,  C12N15/52

CPC分类号： C11D3/38636 ,  C11D3/0068 ,  C11D3/386 ,  C11D3/38645 ,  C11D3/38654 ,  C11D3/48 ,  C11D11/0017 ,  C11D11/0023 ,  C12N9/22 ,  C12N15/52 ,  C12Y301/01074 ,  C12Y301/21001 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y302/01004 ,  C12Y302/01015

摘要： Detergent compositions including polypeptide variants and methods of cleaning and/or treatment of surfaces using such compositions, and fabric treatment compositions including polypeptide variants. The compositions may include surfactants: anionic, nonionic and/or cationic.

公开(公告)号：US11926833B2

公开(公告)日：2024-03-12

申请号：US18153863

申请日：2023-01-12

申请人： Living Carbon PBC

发明人： Madeline Hall ,  Li-Wei Chiu ,  Rebecca Dewhirst ,  Jacob Hoyle ,  Patrick Mellor ,  Karli Rasmussen ,  Yumin Tao

IPC分类号： C12N15/52 ,  C12N15/113

CPC分类号： C12N15/52 ,  C12N15/113 ,  C12N2310/11

摘要： The present disclosure relates to a transgenic plant cell comprising polynucleotide sequences encoding glycolate dehydrogenase, malate synthase, and an inhibitory polynucleotide targeting an endogenous glycolate transporter Plgg1, wherein expression of endogenous glycolate transporter Plgg1 in the transgenic plant cell is about 20% to 80% of expression of endogenous glycolate transporter Plgg1 in a plant cell that is not transformed with an inhibitory polynucleotide targeting an endogenous glycolate transporter Plgg1. Also disclosed are transgenic plants, transgenic plant cultures, and methods for increasing photosynthesis efficiency in plants. The disclosed methods enhance biomass productivity and reduce the negative impact of photorespiration and introduction of transgenic constructs on plant growth.

公开(公告)号：US11913006B2

公开(公告)日：2024-02-27

申请号：US16355215

申请日：2019-03-15

申请人： Commonwealth Scientific and Industrial Research Organisation

发明人： Kyle B. Reynolds ,  Thomas Vanhercke ,  Anna El Tahchy ,  Qing Liu ,  Surinder S. Singh ,  James R. Petrie

IPC分类号： C12N15/82 ,  C12N9/10 ,  C10L1/02 ,  C12N9/16 ,  C12N15/52 ,  C10G3/00

CPC分类号： C12N15/8247 ,  C10G3/00 ,  C10L1/02 ,  C10L1/026 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C10L2200/0476 ,  C12Y203/01158 ,  C12Y301/02014

摘要： The present invention relates to methods of producing industrial products from plant lipids, particularly from vegetative parts of plants. In particular, the present invention provides oil products such as biofuel, and processes for producing these products, as well as plants having an increased level medium chain fatty acids such as lauric acid and myristic acid. In one particular embodiment, the present invention relates to combinations of modifications in a fatty acid thioesterase and one or more acyltransferases. In an embodiment, the present invention relates to a process for extracting lipids. In another embodiment, the lipid is converted to one or more hydrocarbon products in harvested plant vegetative parts to produce alkyl esters of the fatty acids which are suitable for use as a renewable biofuel.

公开(公告)号：US11912744B2

公开(公告)日：2024-02-27

申请号：US16842489

申请日：2020-04-07

申请人： Antibiotic Alternatives LLC

发明人： Mark C. Herzberg ,  Karen Farnie Ross ,  Brent S. Sorenson

IPC分类号： A61K48/00 ,  C12N15/87 ,  C12N15/52 ,  A61K31/7105 ,  C12N15/12 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K48/00 ,  A61K48/005 ,  C12N15/87 ,  C12N2840/203

摘要： This disclosure describes compositions and methods involved in tumor suppression and inhibiting infection of cells by pathogens. Generally, the compositions include an mRNA cargo that can provide a therapeutic benefit after being introduced into an epithelial cell. In some cases, the mRNA can encode a polypeptide. In some cases, the polypeptide can suppress epithelial cell proliferation. In other embodiments, the polypeptide can be involved in innate immunity. In various embodiments, the polypeptide can include cathelicin antimicrobial protein (CAMP), calprotectin, S100A8, S100A9, a β-defensin, S100A7, secretory leukocyte inhibitor, lipocalin 2, or lysozyme. In some embodiments, the mRNA can include a stabilizing moiety such as, for example, a 5′ cap or a 3′ extension.