公开(公告)号：US20230183195A1

公开(公告)日：2023-06-15

申请号：US17906367

申请日：2021-03-15

申请人： PALOBIOFARMA, S.L.

发明人： Julio Castro PALOMINO LARIA ,  Juan CAMACHO GÓMEZ

IPC分类号： C07D277/56 ,  A61K45/06 ,  C07C65/05 ,  C07C275/02 ,  C07D213/82

CPC分类号： C07D277/56 ,  A61K45/06 ,  C07C65/05 ,  C07C275/02 ,  C07D213/82 ,  C07B2200/13

摘要： The present invention relates to the cocrystals of (1R,3S)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcarbamoyl)cyclopentane carboxylic acid, a process for obtaining said cocrystals, combination products and pharmaceutical compositions comprising said cocrystals and their medical uses, in particular for the treatment or prevention of diseases known to ameliorate by A1 adenosine receptor antagonism.

公开(公告)号：US11083976B2

公开(公告)日：2021-08-10

申请号：US15560460

申请日：2016-03-29

申请人： Stamicarbon B.V.

发明人： Joey Dobree ,  Johannes Henricus Mennen

IPC分类号： B01J19/24 ,  C01C1/18 ,  C07C273/04 ,  B01D3/00 ,  C05C9/00 ,  C05C1/00 ,  C07C273/02 ,  C05G5/23 ,  B01J19/00 ,  C07C273/10 ,  C07C275/02

摘要： Disclosed is a method for the integrated production of two different urea products. One is an aqueous urea solution suitable for use in NOx abatement (generally indicated as Diesel Exhaust Fluid—DEF). The other is a solution used as a fertilizer, viz. Urea Ammonium Nitrate (UAN). The production of DEF and UAN are integrated as follows: ammonia recovered from the production of urea is used as a feed to the production of ammonium nitrate. At least part of an aqueous urea stream from urea prodution, is mixed with ammonium nitrate so as to obtain UAN.

公开(公告)号：US10991984B2

公开(公告)日：2021-04-27

申请号：US15008487

申请日：2016-01-28

申请人： SEMICONDUCTOR ENERGY LABORATORY CO., LTD.

发明人： Toru Itakura ,  Kyosuke Ito ,  Rie Yokoi ,  Jun Ishikawa

IPC分类号： H01M10/0569 ,  H01M10/0568 ,  H01M10/052 ,  C25D3/44 ,  C07C275/02 ,  C07C275/06 ,  C25D3/66 ,  C07C233/05

摘要： A nonaqueous electrolyte of the present invention includes an ionic liquid including a first alicyclic quaternary ammonium cation having one or more substituents, a second alicyclic quaternary ammonium cation having an alicyclic skeleton that is the same as an alicyclic skeleton of the first alicyclic quaternary ammonium cation, and a counter anion to the first alicyclic quaternary ammonium cation and the second alicyclic quaternary ammonium cation and an alkali metal salt. In the second alicyclic quaternary ammonium cation, one of substituents bonded to a nitrogen atom in the alicyclic skeleton is a substituent including a halogen element. In the ionic liquid, the amount of a salt including the second alicyclic quaternary ammonium cation is less than or equal to 1 wt % per unit weight of the ionic liquid, or is less than or equal to 0.8 wt % per unit weight of the nonaqueous electrolyte.

公开(公告)号：US10766856B2

公开(公告)日：2020-09-08

申请号：US16698734

申请日：2019-11-27

申请人： STAMICARBON B.V.

发明人： Eelco Mostert

IPC分类号： C07C273/04 ,  B01D53/58 ,  C07C273/16 ,  B01J4/00 ,  C07C275/02 ,  C07C275/62

摘要： Disclosed is a novel method of controlling the formation of biuret in urea production, and particularly reducing, preventing or reversing such formation. This is accomplished by adding liquid ammonia to a urea aqueous stream. This addition is done at one or more positions downstream of a recovery section in a urea plant. The addition of liquid ammonia serves to shift the equilibrium of biuret formation from urea, to the side of the formation of urea from biuret and ammonia. The invention can be accomplished also in pre-existing urea plant, by the simple measure of providing an appropriate inlet for liquid ammonia, in fluid communication with a source of such liquid ammonia.

公开(公告)号：US10376859B2

公开(公告)日：2019-08-13

申请号：US15576214

申请日：2017-03-30

申请人： STAMICARBON B.V.

发明人： Juan Coloma González ,  Luc Louis Maria Dieltjens ,  Johannes Henricus Mennen

IPC分类号： B01J19/00 ,  B01J19/18 ,  B01J19/24 ,  B01D3/06 ,  B01D3/14 ,  B01D5/00 ,  C07C273/04 ,  C07C275/02 ,  B01L3/06 ,  B01L3/14

摘要： The invention is directed to a urea plant with a high pressure synthesis section and a recovery section. The high pressure synthesis section comprises a reactor, a stripper and a condenser, wherein the reactor operates at a higher pressure than the stripper and the condenser. The plant further includes a compression unit between the condenser and the reactor. The compression unit utilizes mechanical energy recovered from a decompression unit positioned downstream of the stripper and upstream of the recovery section.

公开(公告)号：US10150729B2

公开(公告)日：2018-12-11

申请号：US15794530

申请日：2017-10-26

申请人： NUFORMIX LIMITED

发明人： Joanne Holland ,  Christopher Frampton

IPC分类号： C07C233/55 ,  C07C275/02 ,  C07C229/60 ,  C07C235/38 ,  C07D213/82 ,  C07C65/05 ,  C07C65/10 ,  C07C65/03 ,  C07C229/56 ,  C07D275/06

摘要： New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1 tranilast gentisic acid complex, a 1:1 tranilast gentisic acid cocrystal, a 1:1 tranilast salicylic acid complex, a 1:1 tranilast salicylic acid cocrystal, a 1:1 tranilast urea complex, a 1:1 tranilast urea cocrystal, a 1:1 tranilast 4-aminobenzoic acid complex, a 1:1 tranilast 4-aminobenzoic acid cocrystal, a 1:1 tranilast 2,4-dihydroxybenzoic acid complex and a 1:1 tranilast 2,4-dihydroxybenzoic acid cocrystal. Also disclosed are pharmaceutical compositions containing a tranilast complex or cocrystal of the invention and a pharmaceutically acceptable carrier. Methods of treatment using the tranilast complexes and cocrystals as well as the pharmaceutical compositions are disclosed.

公开(公告)号：US20180244696A1

公开(公告)日：2018-08-30

申请号：US15966157

申请日：2018-04-30

申请人： AMGEN, INC.

发明人： David BAUER ,  Matthew BIO ,  Melanie COOKE ,  Katrina W. COPELAND ,  Matthew PETERSON ,  Michele POTASHMAN ,  Roman SHIMANOVICH ,  Helming TAN

IPC分类号： C07D519/00 ,  A61K31/52 ,  C07C57/145 ,  C07C57/10 ,  C07C55/12 ,  C07C55/10 ,  C07C275/02

CPC分类号： C07D519/00 ,  A61K31/52 ,  C07B2200/13 ,  C07C55/10 ,  C07C55/12 ,  C07C57/10 ,  C07C57/145 ,  C07C275/02

摘要： Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the invention provides polymorphs and co-crystals of 6-{(1R)-1-[8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, which is an inhibitor of c-Met.

公开(公告)号：US20180071653A1

公开(公告)日：2018-03-15

申请号：US15560460

申请日：2016-03-29

申请人： Stamicarbon B.V.

发明人： Joey DOBREE ,  Johannes Henricus MENNEN

IPC分类号： B01D3/00 ,  C01C1/18 ,  C07C273/04 ,  C07C273/10 ,  C07C275/02 ,  C05G3/00 ,  C05C1/00 ,  C05C9/00 ,  B01J19/00

CPC分类号： B01D3/009 ,  B01D3/00 ,  B01J19/002 ,  C01C1/185 ,  C05C1/00 ,  C05C9/00 ,  C05G3/0076 ,  C07C273/02 ,  C07C273/04 ,  C07C273/10 ,  C07C275/02 ,  Y02P20/127 ,  C05C9/005

摘要： Disclosed is a method for the integrated production of two different urea products. One is an aqueous urea solution suitable for use in NOx abatement (generally indicated as Diesel Exhaust Fluid—DEF). The other is a solution used as a fertilizer, viz. Urea Ammonium Nitrate (UAN). The production of DEF and UAN are integrated as follows: ammonia recovered from the production of urea is used as a feed to the production of ammonium nitrate. At least part of an aqueous urea stream from urea prodution, is mixed with ammonium nitrate so as to obtain UAN.

公开(公告)号：US20110290418A1

公开(公告)日：2011-12-01

申请号：US13177921

申请日：2011-07-07

申请人： Philip T. Klemarczyk ,  David Birkett ,  David Farrell ,  Peter Wrobel ,  Ciaran McArdle ,  Greg Clarke

发明人： Philip T. Klemarczyk ,  David Birkett ,  David Farrell ,  Peter Wrobel ,  Ciaran McArdle ,  Greg Clarke

IPC分类号： B32B37/12 ,  C07C233/31 ,  C07C275/02 ,  C07D207/26 ,  C09J4/02 ,  C09K3/00

CPC分类号： C07C275/02 ,  C07C275/06 ,  C09J4/00 ,  C09J5/06

摘要： Provided is a complex of hydrogen peroxide and at least one compound represented by Formula I: wherein X is: —C(R3)3, —C≡C(R3), —O(R3), —N(R3)2, or —S(R3); and R1, R2, and R3 are each independently selected from H, alkyl, alkenyl, alkynyl, aralkyl, aryl, heteroaryl heteroarylalkyl, heterocyclyl, and cycloalkyl, or R2 and an R3 are optionally taken together to form an alicyclic ring. Also provided are anaerobic cure systems and curable compositions employing the complexes described herein.

摘要翻译： 提供了过氧化氢和至少一种由式I表示的化合物的络合物：其中X是：-C（R 3）3，-C≡C（R 3），-O（R 3），-N（R 3）2或 -S（R 3）; 并且R 1，R 2和R 3各自独立地选自H，烷基，烯基，炔基，芳烷基，芳基，杂芳基杂芳基烷基，杂环基和环烷基，或者R 2和R 3任选地一起形成脂环族环。 还提供了使用本文所述复合物的厌氧固化体系和可固化组合物。

公开(公告)号：US20060287392A1

公开(公告)日：2006-12-21

申请号：US11461830

申请日：2006-08-02

申请人： Matthew Peterson ,  Mark Oliveira

发明人： Matthew Peterson ,  Mark Oliveira

IPC分类号： A61K31/195 ,  C07C229/28 ,  C07C275/02

CPC分类号： C07C59/255 ,  C07C57/145

摘要： The present invention comprises an organic acid salt of gabapentin, wherein the organic acid is tartaric acid, ethanedisulfonic acid, or maleic acid. Methods for modulating the solubility and dose response of gabapentin are discussed. Methods of making organic acid salts of gabapentin are also discussed.

摘要翻译： 本发明包括加巴喷丁的有机酸盐，其中有机酸是酒石酸，乙二磺酸或马来酸。 讨论了调节加巴喷丁的溶解度和剂量反应的方法。 还讨论了加巴喷丁的有机酸盐的制备方法。