公开(公告)号：US20030150988A1

公开(公告)日：2003-08-14

申请号：US10066276

申请日：2002-01-30

Inventor： Gregory J. Wells

IPC: H01J049/42

CPC classification number: H01J49/424 ,  H01J49/428

Abstract: In a quadrupole ion trap mass spectrometer, a library of optimized notched waveforms are pre-calculated, optimized and stored in a fast memory such as semiconductor RAM. Computer controlled apparatus selectively applies the pre-calculated waveforms to end caps of the quadrupole ion trap for isolating an ion with a specific mass to charge ratio. The pre-calculated waveforms are optimized notch waveforms with each waveform being pre-calculated for a specific mass. The memory further stores a library of single frequency CID waveforms for use in collision induced dissociation of an isolated ion. By providing the pre-calculated waveforms, a method is provided to isolate and dissociate a selected ion.

Abstract translation: 在四极离子阱质谱仪中，预先计算，优化并存储在诸如半导体RAM的快速存储器中的优化的缺口波形库。 计算机控制的设备选择性地将预计算的波形应用于四极离子阱的端盖，以分离具有特定质荷比的离子。 预先计算的波形是针对特定质量预先计算每个波形的最佳陷波波形。 存储器还存储用于分离离子的碰撞诱导解离的单频CID波形库。 通过提供预先计算的波形，提供了隔离和离解选定离子的方法。

公开(公告)号：US20020166958A1

公开(公告)日：2002-11-14

申请号：US09840633

申请日：2001-04-23

Inventor： Noubar B. Afeyan ,  Scott McLuckey ,  Fred E. Regnier

IPC: H01J049/42

CPC classification number: H01J49/0077 ,  G01N30/72 ,  H01J49/4265 ,  H01J49/428

Abstract: The methods of the invention exploit the mass-to-charge ratio dependent motion of ions in an electrodynamic ion traps in synergy with a charge quenching process. In an electrodynamic ion trap, each mass-to-charge ratio is characterized by a unique set of frequencies of motion. Accordingly, by tailoring the time-varying electrical potential of the ion trap the invention controls which ions are allowed or retained in the ion trap and which ions are subjected to charge quenching reactions. Control of ion retention and charge quenching is used to improve sample throughput, dynamic mass range and signal discrimination in the mass spectrometry of multiply charged ions.

Abstract translation: 本发明的方法利用电动力离子阱中的离子的质荷比依赖运动与电荷淬灭过程协同作用。 在电动离子阱中，每个质荷比通过一组独特的运动频率来表征。 因此，通过调整离子阱的时变电位，本发明控制哪些离子被允许或保留在离子阱中以及哪些离子进行电荷淬灭反应。 离子保留和电荷淬灭的控制用于提高多电荷离子质谱中的样品通量，动态质量范围和信号鉴别。

公开(公告)号：US20010010355A1

公开(公告)日：2001-08-02

申请号：US09769483

申请日：2001-01-26

Applicant: Shimadzu Corporation

Inventor： Yoshikatsu Umemura

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/428 ,  G01N23/046 ,  G01N2223/419

Abstract: A method of producing a broad-band signal including a plurality of component frequencies of regular or irregular intervals, where the broad-band signal is used to apply an alternating voltage to the end cap electrodes of an ion trap mass spectrometer. The method includes the following steps: (S3) a sinusoidal signal having one of the component frequencies with 0null initial phase angle is generated; (S4) the sinusoidal signal is added to a current temporary superposed signal to produce an addition signal; (S5) the sinusoidal signal is subtracted from the current temporary superposed signal to produce a subtraction signal; (S6-S12) either of the addition signal or the subtraction signal is selected that has a smaller amplitude as a next temporary superposed signal; and (S13) the steps are repeated for all the component frequencies.

Abstract translation: 一种产生宽带信号的方法，该宽带信号包括常规或不规则间隔的多个分量频率，其中宽带信号用于向离子阱质谱仪的端盖电极施加交流电压。 该方法包括以下步骤：（S3）产生具有0°初始相位角的分量频率之一的正弦信号; （S4）将正弦信号加到当前临时叠加信号中以产生加法信号; （S5）从当前临时叠加信号中减去正弦信号，产生减法信号; （S6-S12）选择具有较小振幅的相加信号或减法信号中的任一个作为下一临时叠加信号; 和（S13）对于所有分量频率重复步骤。

公开(公告)号：US5345078A

公开(公告)日：1994-09-06

申请号：US90474

申请日：1993-07-12

Applicant: Paul E. Kelley

Inventor： Paul E. Kelley

IPC: G01N27/62 ,  H01J49/42

CPC classification number: H01J49/424 ,  H01J49/0081 ,  H01J49/428

Abstract: A mass spectrometry method in which notch-filtered noise is applied to an ion trap to resonate all ions except selected parent ions out of the region of the trapping field. Preferably, the trapping field is a quadrupole trapping field defined by a ring electrode and a pair of end electrodes positioned symmetrically along a z-axis, and the filtered noise is applied to the ring electrode (rather than to the end electrodes) to eject unwanted ions in radial directions (toward the ring electrode) rather than toward a detector mounted along the z-axis. Application of the filtered noise to the trap in this manner can significantly increase the operating lifetime of such an ion detector. Also preferably, the trapping field has a DC component selected so that the trapping field has both a high frequency and low frequency cutoff, and is incapable of trapping ions with resonant frequency below the low frequency cutoff or above the high frequency cutoff. Application of the filtered noise signal of the invention to such a trapping field is functionally equivalent to filtration of the trapped ions through a notched bandpass filter having such high and low frequency cutoffs. Application of filtered noise in accordance with the invention has several significant advantages over the conventional techniques it replaces, including avoidance of accumulation of contaminating ions during the process of storing desired parent ions, ejection of unwanted ions in directions away from an ion detector to enhance the detector's operating life, rapid ejection of unwanted ions having mass-to-charge ratio below a minimum value, above a maximum value, and outside a window (between the minimum and maximum values) determined by the filtered noise signal.

Abstract translation: 一种质谱方法，其中将陷波滤波的噪声施加到离子阱以使除所选母体离子之外的所有离子在捕获场的区域外谐振。 优选地，捕获场是由环形电极和沿着z轴对称定位的一对端电极限定的四极捕获场，并且将滤波的噪声施加到环形电极（而不是端部电极）以排出不需要的 离子沿径向（朝向环形电极）而不是沿着沿z轴安装的检测器。 以这种方式将滤波噪声施加到陷阱可以显着增加这种离子检测器的工作寿命。 还优选地，俘获场具有选择的DC分量，使得捕获场具有高频和低频截止频率，并且不能捕获具有低于低频截止频率或高于高频截止频率的谐振频率的离子。 将本发明的滤波噪声信号应用于这种捕获场在功能上等同于通过具有这种高频和低频截止值的有​​缺口带通滤波器对捕获的离子的过滤。 根据本发明的滤波噪声的应用与其替代的常规技术相比具有几个显着的优点，包括避免在存储期望的母体离子的过程中污染离子的积累，不期望的离子沿远离离子检测器的方向喷射以增强 检测器的使用寿命，快速排出具有低于最小值的质荷比低于最大值的不想要的离子，以及由滤波的噪声信号确定的窗口之外（在最小值和最大值之间）。

公开(公告)号：US20180130649A1

公开(公告)日：2018-05-10

申请号：US15808036

申请日：2017-11-09

Applicant: Thermo Finnigan LLC

Inventor： Philip M. REMES

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/422 ,  H01J49/4265 ,  H01J49/428

Abstract: This disclosure describes a method of adjusting the amplitude of broadband waveforms for isolation, especially during injection to a multipole trapping device. Isolation during injection to a trapping device is known to be an effective way of accumulating a desired population of ions while rejecting unwanted species. The waveform amplitude required to eject unwanted species varies as a function of isolation time, but using automated gain control, the time required to accumulate a given population of ions may vary over several orders of magnitude. Thus, when the injection times are very long, precursor ions of interest are resonated for a long time and may be inadvertently ejected from the trap, using conventional methods. By setting the waveform amplitude lower for longer accumulation times, good isolation efficiency can be maintained for the precursor, while still rejecting unwanted ions.

公开(公告)号：US20160020083A1

公开(公告)日：2016-01-21

申请号：US14772395

申请日：2014-03-12

Applicant: PRESIDENT AND FELLOWS OF HARVARDD COLLEGE

Inventor： Graeme Conrad McAlister ,  Steven P. Gygi

IPC: H01J49/42

CPC classification number: H01J49/428

Abstract: A mass spectrometry technique for isolating a plurality of isolated ions from a plurality of injected ions using a dynamic isolation waveform to create at least one isolation notch. Isolating the plurality of isolated ions may include collecting at least a first target ion, but not a second target ion, using the at least one isolation notch for a first period of time; changing at least one property of the at least one isolation notch; and collecting at least the first target ion and the second target ion using the at least one isolation notch for a second period of time.

Abstract translation: 一种用于使用动态隔离波形从多个注入离子中分离多个孤立离子以产生至少一个隔离陷波的质谱技术。 隔离多个隔离的离子可以包括使用至少一个隔离缺口在第一时间段内收集至少第一目标离子而不是第二目标离子; 改变所述至少一个隔离槽口的至少一个特性; 以及使用所述至少一个隔离凹口在第二时间段内收集至少所述第一靶离子和所述第二靶离子。

公开(公告)号：US20150380231A1

公开(公告)日：2015-12-31

申请号：US14768376

申请日：2014-02-18

Applicant: MICROMASS UK LIMITED

Inventor： Jeffery Mark Brown ,  Martin Raymond Green ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/42 ,  H01J49/0027 ,  H01J49/005 ,  H01J49/0054 ,  H01J49/0072 ,  H01J49/428

Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device.

Abstract translation: 公开了用于质谱仪的碰撞或反应装置，其包括布置并适于使第一离子与带电粒子和/或中性粒子碰撞或反应的第一装置，或以其它方式解离以形成第二离子。 碰撞或反应装置还包括布置并适于将具有一个或多个频率凹口的宽带激发施加到第一装置的第二装置，以便使来自第二离子的第二离子和/或离子从 第一装置，而不会使第一离子从第一装置基本上排出。

公开(公告)号：US20150206733A1

公开(公告)日：2015-07-23

申请号：US14425124

申请日：2013-09-06

Applicant: Waters Technologies Corporation

Inventor： James P. Murphy

IPC: H01J49/26 ,  B01D59/44

CPC classification number: H01J49/26 ,  B01D59/44 ,  H01J49/428

Abstract: Techniques are described for performing mass spectrometry. A quadrupole, or more generally, an electrode-based device, performs mass filtering for selectively filtering ions. One or more components generate a first RF potential, a DC potential, and a supplemental RF potential applied to the quadrupole. The supplemental RF potential has a corresponding multiple notched waveform having a plurality of corresponding frequencies thereby allowing a plurality of ions to pass through the quadrupole at a same time. Each of the plurality of corresponding frequencies corresponds to a notch in the waveform allowing one of the plurality of ions of a different mass or m/z to pass through the quadrupole for processing by another component or device.

Abstract translation: 描述了进行质谱分析的技术。 四极或更一般地，基于电极的装置进行用于选择性过滤离子的质量过滤。 一个或多个组件产生施加到四极杆的第一RF电位，DC电势和补充RF电位。 补充RF电位具有对应的多个具有多个相应频率的多个缺口波形，从而允许多个离子同时穿过四极杆。 多个对应频率中的每一个对应于波形中的凹口，允许不同质量或m / z的多个离子中的一个离子通过四极以供另一个组件或装置处理。

公开(公告)号：US20100084547A1

公开(公告)日：2010-04-08

申请号：US12524378

申请日：2008-01-25

Applicant: Steven Derek Pringle ,  Jason Lee Wildgoose

Inventor： Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/428

Abstract: A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.

Abstract translation: 公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。 具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。 缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。 所得到的离子信号被去卷积以提供质谱。

公开(公告)号：US07378648B2

公开(公告)日：2008-05-27

申请号：US11239932

申请日：2005-09-30

Applicant: Mingda Wang ,  Doris Lee ,  Kenneth Newton ,  Steve Schachterle

Inventor： Mingda Wang ,  Doris Lee ,  Kenneth Newton ,  Steve Schachterle

IPC: H01J49/26

CPC classification number: H01J49/428 ,  H01J49/424

Abstract: A desired ion is isolated in an ion trapping volume by applying an ion isolation signal to a plurality of ions in the ion trapping volume, including the desired ion to be retained in the ion trapping volume and an undesired ion to be ejected from the ion trapping volume. The ion isolation signal includes a plurality of signal components spanning a frequency range. The plurality of signal components includes a first component having a frequency near a secular frequency of the desired ion, and an adjacent component having a frequency adjacent to the frequency of the first component. The first component has an amplitude greater than the amplitude of the adjacent component.

Abstract translation: 通过向离子捕获体积中的多个离子施加离子隔离信号，包括要留在离子俘获体积中的所需离子和从离子捕获物中排出的不需要的离子，将期望的离子分离在离子捕获体积中 卷。 离子隔离信号包括跨越频率范围的多个信号分量。 多个信号分量包括具有接近期望离子的长期频率的频率的第一分量和具有与第一分量的频率相邻的频率的相邻分量。 第一分量具有大于相邻分量振幅的振幅。