公开(公告)号：US09486588B2

公开(公告)日：2016-11-08

申请号：US14168700

申请日：2014-01-30

Applicant: Novo Nordisk A/S

Inventor： Christian Peter Enggaard

IPC: A61M5/00 ,  A61M5/315 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31

CPC classification number: A61M5/3155 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31501 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31583 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2026 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3126

Abstract: The present invention relates to a dose setting and expelling device comprising a drive member and a dose setting mechanism which simultaneously sets a given dose and stores the energy necessary for a subsequently driving the drive member in order to expel a dose of medicine from an injection device. According to the invention the dose setting mechanism allows adjustment in both directions, such that a given set dose can be reduced or cancelled by reversing the input motion, typically by rotating a setting member backwardly, this in contrast to the known devices which either requires an additional release mechanism or which cannot be reversed at all.

Abstract translation: 本发明涉及一种剂量设定和排出装置，其包括驱动构件和剂量设定机构，其同时设定给定剂量并存储随后驱动驱动构件所需的能量，以便从注射装置排出一定剂量的药物 。 根据本发明，剂量设定机构允许在两个方向上进行调节，使得通常通过向后旋转设定构件来反转输入运动可以减少或消除给定的设定剂量，这与已知的装置相反，这些装置需要 额外的释放机制或根本不能逆转。

公开(公告)号：US20160317745A1

公开(公告)日：2016-11-03

申请号：US15108731

申请日：2015-01-05

Applicant: NOVO NORDISK A/S

Inventor： Bastian Gaardsvig Kjeldsen ,  Brian Mouridsen

IPC: A61M5/20 ,  A61M5/315

CPC classification number: A61M5/20 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/3155 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2205/581

Abstract: The present invention relates to an auto-injection device (100) repeatedly activateable for automatically expelling multiple set doses of a liquid drug. An activation button (190) protrudes from a proximal end of a housing (101) and is axially moveable between an activateable position and an activated position. The auto-injection device includes dose setting means comprising a dose setting device (170) that performs a helical movement away from a zero dose position during setting of a dose and returns by a helical movement to the zero dose position as the set dose is expelled. The dose setting device (170) is coupled to the activation button (190) to retain the activation button in the activated position when the dose setting device (170) assumes its zero dose position.

Abstract translation: 本发明涉及自动注射装置（100），其能够自动排出多个剂量的液体药物。 激活按钮（190）从壳体（101）的近端突出并且在可激活位置和激活位置之间可轴向移动。 自动注射装置包括剂量设定装置，其包括剂量设定装置（170），其在剂量设定期间执行远离零剂量位置的螺旋运动，并且当设定剂量被排出时通过螺旋运动返回到零剂量位置 。 当剂量设定装置（170）呈现其零剂量位置时，剂量设定装置（170）耦合到激活按钮（190）以将激活按钮保持在激活位置。

公开(公告)号：US20160310675A1

公开(公告)日：2016-10-27

申请号：US15141213

申请日：2016-04-28

Applicant: SHL Group AB

Inventor： Stephan Olson ,  Lennart Brunnberg

IPC: A61M5/315 ,  A61M5/31 ,  A61M5/32 ,  A61M5/19 ,  A61M5/20

CPC classification number: A61M5/31586 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31505 ,  A61M5/31525 ,  A61M5/31553 ,  A61M5/3156 ,  A61M5/31563 ,  A61M5/3202 ,  A61M5/3257 ,  A61M5/3272 ,  A61M15/0066 ,  A61M2005/2013

Abstract: Injection device comprising a tubular elongated main body, a needle shield slidably arranged in said main body, a needle shield link slidably connected to said needle shield, a enclosure containing medicament arranged in said main body, a needle connected to said enclosure, a plunger operatively arranged to said enclosure for ejecting said medicament through said needle and arranged on its upper part with a number of outwardly extending stop members, spring means arranged to said plunger for operating said plunger, a dose activating means, a needle shield spring surrounding the needle shield link. The invention is characterised in that said injection device further comprises a first tubular member rotationally and slidably arranged inside said needle shield link, said tubular member comprises a number or ridges and protrusions on both its outer and inner surfaces, said ridges and protrusions on the outer surface of the tubular member co-operate with guide members arranged on the inner surface of said needle shield link, said ridges and protrusions on the inner surface of the tubular member co-operate with the outwardly extending stop members of the plunger that said injection device further comprises a second tubular member arranged inside said housing, arranged and designed with a number of ridges and protrusions on its inner and outer surfaces capable of setting and delivering a certain preset dose.

Abstract translation: 注射装置，其包括管状细长主体，可滑动地布置在所述主体中的针护罩，可滑动地连接到所述针护罩的针护罩连接件，包含布置在所述主体中的药物的外壳，连接到所述外壳的针， 布置到所述外壳上，用于通过所述针头排出所述药物并且在其上部上设置有多个向外延伸的止动构件，弹簧装置布置在所述柱塞上用于操作所述柱塞，剂量启动装置，围绕针护罩的针护罩弹簧 链接。 本发明的特征在于，所述注射装置还包括旋转并可滑动地布置在所述针屏蔽连杆内的第一管状构件，所述管状构件在其外表面和内表面上都包括数个或多个隆起和突起，所述脊和突起在外部 管状构件的表面与布置在所述针屏蔽连杆的内表面上的引导构件相配合，所述管状构件的内表面上的所述脊和突起与柱塞的向外延伸的止动构件相配合，所述注射装置 还包括设置在所述壳体内部的第二管状构件，其布置和设计成在其内表面和外表面上具有若干脊和突起，能够设定和递送特定的预设剂量。

公开(公告)号：US09457156B2

公开(公告)日：2016-10-04

申请号：US13495430

申请日：2012-06-13

Applicant: Fritz Kirchhofer

Inventor： Fritz Kirchhofer

IPC: A61M5/32 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/326 ,  A61M5/3146 ,  A61M5/31553 ,  A61M5/3156 ,  A61M5/3157 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3272 ,  A61M2005/3247 ,  A61M2005/3267

Abstract: A device and method for protecting against needle sticks, including a needle protection sleeve for being coupled to an administering device to cover a needle associated with the administering device, wherein the sleeve can be moved against the force of a spring from an extended position to a retracted position and by the force of the spring from the retracted position to the extended position, the spring being carried on the needle protection sleeve.

Abstract translation: 一种用于防止针刺的装置和方法，包括针保护套，用于联接到施用装置以覆盖与施用装置相关联的针，其中所述套筒可以克服弹簧的力从伸展位置运动到 缩回位置和弹簧的力从缩回位置到延伸位置，弹簧承载在针保护套上。

公开(公告)号：US09440030B2

公开(公告)日：2016-09-13

申请号：US13885876

申请日：2011-11-18

Applicant: Anders Holmqvist

Inventor： Anders Holmqvist

IPC: A61M5/315

CPC classification number: A61M5/31551 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31525 ,  A61M5/31543 ,  A61M5/3155 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/3156 ,  A61M5/31583 ,  A61M5/31585 ,  A61M2005/202 ,  A61M2005/2073

Abstract: The invention relates to a medicament delivery device comprising a housing arranged to receive a medicament container (20), a drive unit (25) arranged to act on a stopper (27) in said medicament container (20), which drive unit (25) comprises a torsion drive spring (50). A dose setting member (56) is operably connected to said drive unit (25) such that a manual turning of said dose setting member (56) causes a tensioning of said torsion drive spring (50). The device further comprises an activation mechanism (76) having an activation button (94) protruding through the distal end of the device, wherein said activation mechanism (76) is operably connected to said drive unit (25) such that actuation of said activation mechanism (76) causes a release of said drive unit (25) whereby a set dose of medicament is delivered.

Abstract translation: 本发明涉及药物输送装置，其包括设置成容纳药物容器（20）的壳体，布置成作用在所述药物容器（20）中的止动件（27）上的驱动单元（25），所述驱动单元（25） 包括扭转驱动弹簧（50）。 剂量设定构件（56）可操作地连接到所述驱动单元（25），使得所述剂量设定构件（56）的手动转动导致所述扭转驱动弹簧（50）的张紧。 该装置还包括具有突出穿过装置的远端的启动按钮（94）的启动机构（76），其中所述启动机构（76）可操作地连接到所述驱动单元（25），使得致动所述启动机构 （76）导致所述驱动单元（25）的释放，从而输送一定剂量的药物。

公开(公告)号：US20160206826A1

公开(公告)日：2016-07-21

申请号：US14915430

申请日：2014-09-03

Applicant: SANOFI

Inventor： Simon Lewis Bilton ,  David Aubrey Plumptre ,  Matthew Jones ,  Joseph Butler

IPC: A61M5/315

CPC classification number: A61M5/31551 ,  A61M5/20 ,  A61M5/31528 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31583 ,  A61M5/31586 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2073 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582

Abstract: The present invention relates to a pen type drug injection device (1; 101) comprising a housing (4, 5; 104, 105), a dose dial member (6; 106), a torsion spring (12; 112) fixed between the housing and the dial member such that energy is accumulated in the torsion spring upon rotation of the dial member relative to the housing, a drive member (8; 108) engaging a lead screw (9; 109), a first clutch (18; 118) rotationally coupling the drive member (8; 108) and the housing in a coupled state and allowing relative rotation between the drive member and the housing in a de-coupled state, and a second clutch (19; 119) rotationally coupling the drive member and the dial member in a coupled state and allowing relative clockwise and anti-clockwise rotation between the drive member and the dial member in a de-coupled state. The second clutch comprises a ratchet clicker with teeth (19a, 19b; 119a, 119b) having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the second clutch with a different resistance in the clockwise and the anti-clockwise direction, such that a dose can be set and also corrected by the user thereby tensioning respectively relaxing the torsion spring.

Abstract translation: 本发明涉及一种笔式药物注射装置（1; 101），其包括壳体（4,5; 104,105），剂量拨号构件（6; 106），扭簧（12; 112） 壳体和拨盘构件，使得当拨盘构件相对于壳体旋转时，能量在扭簧中积累;与导螺杆（9; 109）接合的驱动构件（8; 108），第一离合器（18; 118） 在所述驱动构件（8; 108）和所述壳体之间以耦合状态旋转地联接并允许所述驱动构件和所述壳体之间的脱耦合状态相对旋转;以及第二离合器（19; 119），其将所述驱动构件 以及拨号构件处于联接状态，并且允许驱动构件和拨号构件之间的脱耦合状态下的相对顺时针和逆时针旋转。 第二离合器包括具有顺时针和逆时针方向的齿（19a，19b; 119a，119b）的棘轮回转器，斜齿角度不同，使得允许齿在第二离合器的脱耦合状态下彼此超越 第二离合器在顺时针和逆时针方向上具有不同的阻力，使得可以设定剂量并且还可以由使用者校正，从而分别张紧扭转弹簧。

公开(公告)号：US20160175528A1

公开(公告)日：2016-06-23

申请号：US15054312

申请日：2016-02-26

Applicant: OWEN MUMFORD LIMITED

Inventor： Jeremy MARSHALL ,  Clive NICHOLLS ,  Stephen Douglas BICKNELL

IPC: A61M5/20 ,  A61M5/32

CPC classification number: A61M5/2033 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31501 ,  A61M5/31515 ,  A61M5/31553 ,  A61M5/31563 ,  A61M5/31578 ,  A61M5/31591 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/2407 ,  A61M2005/31508 ,  A61M2005/3247

Abstract: A substance delivery device (autoinjector) for use with a container (such as a syringe) containing the substance includes: a body arranged to house or hold the container; a plunger which is movable with respect to at least a portion of the body, the plunger being arranged to act upon the container so as to move the container with respect to the portion of the body; wherein the plunger is also arranged to expel at least a portion of the substance from the container; and wherein the device includes elements for adjusting the amount of substance to be expelled from the container. The device can also have elements for priming the container, and can accommodate containers of different size or shape.

Abstract translation: 一种与容纳物质的容器（如注射器）一起使用的物质输送装置（自动注射器）包括：容纳或容纳容器的主体; 柱塞，其相对于所述主体的至少一部分是可移动的，所述柱塞布置成作用在所述容器上，以使所述容器相对于所述主体的所述部分移动; 其中所述柱塞还被布置成从所述容器排出所述物质的至少一部分; 并且其中所述装置包括用于调节要从所述容器排出的物质的量的元件。 该装置还可以具有用于起动容器的元件，并且可以容纳不同尺寸或形状的容器。

公开(公告)号：US20160158462A1

公开(公告)日：2016-06-09

申请号：US14962508

申请日：2015-12-08

Applicant: Becton, Dickinson and Company

Inventor： Ryan SCHOONMAKER ,  Michel BRUEHWILER ,  Ira SPOOL ,  Melissa ROSEN

IPC: A61M5/48 ,  A61M5/20 ,  A61M5/315 ,  A61M5/142

CPC classification number: A61M5/48 ,  A61M5/14216 ,  A61M5/204 ,  A61M5/286 ,  A61M5/3146 ,  A61M5/31511 ,  A61M5/31553 ,  A61M5/3158 ,  A61M2005/3128 ,  A61M2005/31518 ,  A61M2005/3152

Abstract: A dual-chambered drug delivery device, comprising a cartridge having a first chamber for storing a medicament, a second chamber in fluid communication with said first chamber, a dose setting member for setting a medicament dose to be injected at an injection site, a piston disposed in said second chamber, an upward stroke of said piston drawing a portion of the medicament dose into said second chamber and a downward stroke of said piston expelling the portion of the medicament dose, a needle communicating with said second chamber for sequentially injecting portions of the medicament dose into the injection site, a drive screw movably connected to said dose setting member such that rotation of said dose setting member moves said drive screw upwardly, and a rack movably connected to said drive screw such that downward movement of said drive screw during the medicament dose injection rotates said rack.

Abstract translation: 一种双腔药物输送装置，包括具有用于储存药物的第一腔室和与所述第一腔室流体连通的第二腔室的药筒，用于设定在注射部位注射的药物剂量的剂量设定部件，活塞 设置在所述第二室中，所述活塞的向上冲程将药物剂量的一部分吸入所述第二腔室中，并且所述活塞的向下冲程排出药物剂量的一部分，与所述第二腔室连通的针，以顺序地将部分 药物剂量进入注射部位，驱动螺杆可移动地连接到所述剂量设定部件，使得所述剂量设定部件的旋转向上移动所述驱动螺杆;以及齿条，其可移动地连接到所述驱动螺杆，使得所述驱动螺杆在 药物剂量注射使所述齿条旋转。

公开(公告)号：US20160158456A1

公开(公告)日：2016-06-09

申请号：US14904736

申请日：2014-07-17

Applicant: SANOFI

Inventor： Tom Oakley ,  Matt Schumann ,  Stuart Milne

IPC: A61M5/315

CPC classification number: A61M5/31578 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31501 ,  A61M5/31535 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31561 ,  A61M5/3157 ,  A61M5/31573 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/586

Abstract: A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing (24) and a piston rod (6) having a longitudinal axis (x) and a piston rod feature (17). The drive mechanism further comprises a drive member (1) being movable with respect to the housing (24). The drive member (1) comprises a drive feature (15). The drive feature (15) is selectively engageable with the piston rod feature (17) by the radial displacement of the drive member (1) with respect to the piston rod (6). When the drive member (1) is in the first position, the drive member (1) is disengaged from the piston rod (6), and when the drive member (1) is in the second position, the drive feature (15) is engaged with the piston rod feature (17). When the drive member (1) moves distally with respect to the housing (24), said distal movement is transferred to the piston rod (6) such that the piston rod (6) moves distally with respect to the housing (24).

Abstract translation: 提出了一种用于输送装置的驱动机构。 驱动机构包括具有纵向轴线（x）和活塞杆特征（17）的壳体（24）和活塞杆（6）。 驱动机构还包括可相对于壳体（24）移动的驱动构件（1）。 驱动构件（1）包括驱动特征（15）。 通过驱动构件（1）相对于活塞杆（6）的径向位移，驱动特征（15）可选择性地与活塞杆特征（17）接合。 当驱动部件（1）处于第一位置时，驱动部件（1）从活塞杆（6）脱离，当驱动部件（1）处于第二位置时，驱动部件（15）为 与活塞杆特征（17）接合。 当驱动构件（1）相对于壳体（24）向远侧移动时，所述远端运动被传递到活塞杆（6），使得活塞杆（6）相对于壳体（24）向远侧移动。

公开(公告)号：US20160151580A1

公开(公告)日：2016-06-02

申请号：US14905393

申请日：2014-07-17

Applicant: SANOFI

Inventor： Tom Oakley ,  Karl Hewson ,  Stuart Milne ,  Mark Pawulski

IPC: A61M5/315

CPC classification number: A61M5/31551 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31536 ,  A61M5/31541 ,  A61M5/31545 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2005/31518 ,  A61M2005/3154

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge holder (20) for receiving a cartridge (170), a lead screw (30) and means (40, 90) for driving the lead screw (30) during dose dispensing. The lead screw (30) is coupled to the cartridge holder (20) such that the cartridge holder (20) is axially displaced with respect to the housing (10) and the lead screw (30) during dose dispensing.

Abstract translation: 本发明涉及用于选择和分配多个用户可变剂量的药物的药物递送装置。 该装置包括壳体（10），用于容纳盒（170）的盒保持器（20），用于在剂量分配期间驱动丝杠（30）的导螺杆（30）和装置（40,90）。 导螺杆（30）联接到药筒保持器（20），使得药筒保持器（20）在剂量分配期间相对于壳体（10）和丝杠（30）轴向移位。