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公开(公告)号：US20060183891A1
公开(公告)日：2006-08-17
申请号：US11402491
申请日：2006-04-11
IPC分类号： C07H21/04
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US20060177911A1
公开(公告)日：2006-08-10
申请号：US11403096
申请日：2006-04-11
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US20060177885A1
公开(公告)日：2006-08-10
申请号：US11402543
申请日：2006-04-11
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US08338088B2
公开(公告)日：2012-12-25
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译： 本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。 因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。
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公开(公告)号：US07947507B2
公开(公告)日：2011-05-24
申请号：US12203629
申请日：2008-09-03
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译： 本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。 特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法进行了描述。
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公开(公告)号：US07939292B2
公开(公告)日：2011-05-10
申请号：US12261004
申请日：2008-10-29
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
IPC分类号： C12P1/00
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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公开(公告)号：US20100196940A1
公开(公告)日：2010-08-05
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译： 本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。 因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。
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公开(公告)号：US20100113294A1
公开(公告)日：2010-05-06
申请号：US12596171
申请日：2008-04-15
申请人： Ganesh Venkataraman , Brian Edward Collins , Carlos J. Bosques , Lakshmanan Thiruneelakantapillai , Dorota A. Bulik , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru
发明人： Ganesh Venkataraman , Brian Edward Collins , Carlos J. Bosques , Lakshmanan Thiruneelakantapillai , Dorota A. Bulik , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru
CPC分类号： C12P21/005 , G16B50/00
摘要： The invention provides methods, databases and systems for making glycoprotein products having defined properties.
摘要翻译： 本发明提供了制备具有确定特性的糖蛋白产物的方法，数据库和系统。
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公开(公告)号：US07687479B2
公开(公告)日：2010-03-30
申请号：US11518534
申请日：2006-09-08
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： A01N43/04
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates, in part, to methods and products related to producing low molecular weight heparin.
摘要翻译： 本发明部分涉及生产低分子量肝素的方法和产品。
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公开(公告)号：US20090237078A1
公开(公告)日：2009-09-24
申请号：US12298591
申请日：2007-04-30
CPC分类号： G01N33/9493 , A61K38/02 , G01N33/15 , G01N33/68 , G01N33/6806 , G01N33/6821 , G01N33/6848 , Y10T436/24 , Y10T436/25125
摘要： The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.
摘要翻译： 目前公开的主题提供了用于评估和表征肽，肽混合物和多肽混合物的方法。 更具体地，本发明公开的主题提供了用于评估或表征包含谷氨酸，丙氨酸，酪氨酸和赖氨酸的复合肽或多肽混合物的方法，例如共聚物-1或乙酸格拉默，包括但不限于鉴定， 分离，定量和纯化具有二乙基酰胺基团而不是C末端存在的羧基的氨基酸，肽，多肽及其组合。 目前公开的方法可以用于确定在C末端具有二乙酰胺基团的多肽的摩尔百分比，并且可以用于评估一种多肽混合物的样品的一种或多种性质，与一种或多种性质的 不同样品的多肽混合物。
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