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公开(公告)号：US09790465B2
公开(公告)日：2017-10-17
申请号：US14087906
申请日：2013-11-22
Applicant: CORNING INCORPORATED
Inventor： Scott Matthew Bennett , Brian Robb Douglass , Paul Ernest Gagnon, Jr. , Gregory Roger Martin , Paul Michael Szlosek , Allison Jean Tanner
Abstract: A spheroid cell culture article including: a frame having a chamber including: an opaque side wall surface; a top aperture; a gas-permeable, transparent bottom; and optionally a chamber annex surface and second bottom, and at least a portion of the transparent bottom includes at least one concave arcuate surface, is disclosed. Methods of making and using the article are also disclosed.
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公开(公告)号：US20160144360A1
公开(公告)日：2016-05-26
申请号：US14950481
申请日：2015-11-24
Applicant: Corning Incorporated
Inventor： William Joseph Lacey , Paul Michael Szlosek , Allison Jean Tanner , Joseph Christopher Wall , Kathy Marie Youngbear
CPC classification number: B01L3/50851 , B01L2200/12 , B01L2300/0829 , B01L2300/0858 , B29C45/0001 , B29C51/002 , B29C51/10 , B29C51/428 , B29K2023/12 , B29K2105/256 , B29K2995/0026 , B29L2031/752
Abstract: A method of forming microplate includes forming a preform microplate including a deck and a plurality of wells, and reforming at least one well of the plurality of wells to provide a microplate. Each well of the plurality of wells in the preform microplate has a first depth and a first wall thickness. At least one well of the microplate has a second depth and a second wall thickness, where the second depth is greater than the first depth and/or the second wall thickness is less than the first wall thickness.
Abstract translation: 形成微孔板的方法包括形成包括甲板和多个孔的预成型微孔板，以及重整多个孔中的至少一个孔以提供微孔板。 预成型微孔板中的多个孔的每个孔具有第一深度和第一壁厚度。 微孔板的至少一个孔具有第二深度和第二壁厚，其中第二深度大于第一深度和/或第二壁厚度小于第一壁厚度。
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公开(公告)号：US20160144359A1
公开(公告)日：2016-05-26
申请号：US14950453
申请日：2015-11-24
Applicant: Corning Incorporated
Inventor： William Joseph Lacey , Paul Michael Szlosek , Allison Jean Tanner , Wai Kin Poon
CPC classification number: B01L3/50851 , B01L2200/028 , B01L2200/12 , B01L2300/0654 , B01L2300/0829
Abstract: A reinforced microplate includes a microplate main body having a deck and a plurality of wells, and a reinforcing member. The deck includes a first surface and a second surface. Each well of the plurality of wells extends from the second surface in a substantially perpendicular direction, and each well comprises an opening on the first surface. The reinforcing member is attached to at least one surface of the deck.
Abstract translation: 增强微孔板包括具有甲板和多个孔的微板主体和加强构件。 甲板包括第一表面和第二表面。 多个井中的每个井在基本上垂直的方向上从第二表面延伸，并且每个井包括在第一表面上的开口。 加强构件附接到甲板的至少一个表面。
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公开(公告)号：US09040290B2
公开(公告)日：2015-05-26
申请号：US14075446
申请日：2013-11-08
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/08 , C12M23/04 , C12M23/24 , C12M23/34 , C12M23/38 , C12M23/58 , C12M25/02 , C12M25/04 , C12M25/06 , C12M29/04 , C12N5/0602
Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.
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公开(公告)号：US20240301336A1
公开(公告)日：2024-09-12
申请号：US18571999
申请日：2022-06-14
Applicant: CORNING INCORPORATED
Inventor： Thomas Albert Cloutier , William Joseph Lacey , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: A protective carrier for a microcavity vessel is provided. The protective carrier comprises a substantially flat rigid plate comprising a top surface and a bottom surface. A flange disposed around at least a portion of a perimeter of the rigid plate, the flange extending from the top surface of the rigid plate. One or more ribs disposed on the bottom surface of the rigid plate. A protective microcavity vessel carrier system is provided that comprises a microcavity vessel comprising a microcavity substrate on a bottom surface; and a protective carrier. The microcavity vessel may be a microcavity flask, microcavity plate such as an open well reservoir plate, microcavity bioreactor, or a stacked 3D microcavity culture vessel.
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Patent Agency Ranking
公开(公告)号：US11976263B2
公开(公告)日：2024-05-07
申请号：US17691511
申请日：2022-03-10
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.
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公开(公告)号：US20240091778A1
公开(公告)日：2024-03-21
申请号：US18525119
申请日：2023-11-30
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
CPC classification number: B01L3/5085 , C12M23/08 , C12M23/38 , B01L2300/0858
Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
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公开(公告)号：US11932838B2
公开(公告)日：2024-03-19
申请号：US17746473
申请日：2022-05-17
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner , Alexander Meyer Wilks
CPC classification number: C12M23/08 , C12M23/20 , C12N5/0682
Abstract: This disclosure provides a cell culture media extending material capable of releasing nutrients into the cell culture environment slowly overtime. In embodiments, this material is a part of a cell culture vessel. In embodiments, the material is a coating or a film on a surface of a cell culture material. In additional embodiments, the material is a surface upon which cells are cultured, such as a cell culture vessel or a microcarrier.
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公开(公告)号：US20230416664A1
公开(公告)日：2023-12-28
申请号：US18037229
申请日：2021-11-17
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Allison Jean Tanner
Abstract: Cell culture devices comprise a frame comprising an open well disposed therein and a fluid inlet area in communication with the open well. The open well comprises a top opening, a bottom plate comprising a microcavity substrate, the bottom plate defining a major surface, and one or more sidewalls extending from the bottom plate to the top opening. The microcavity substrate comprises a plurality of microcavities, and each microcavity is configured such that cells cultured in the well form a spheroid. The cell culture device may be a reservoir open well microcavity plate used for spheroid cell culture.
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公开(公告)号：US20230330600A1
公开(公告)日：2023-10-19
申请号：US18018987
申请日：2021-07-28
Applicant: CORNING INCORPORATED
Inventor： Ana Maria del Pilar Pardo , Allison Jean Tanner
CPC classification number: B01D61/18 , B01D61/145 , B01D71/68 , B01D63/16 , B01D69/02 , B01D67/0088 , B01L3/5021 , B01D2325/34 , B01L2300/0681 , B01L2300/042
Abstract: A coated ultrafiltration device comprises an upper chamber; a lower chamber; a filtration chamber disposed between the upper chamber and lower chamber; and a semipermeable membrane disposed substantially vertically around the filtration chamber. The semipermeable membrane comprises a coating on a portion of the semipermeable membrane exposed to the filtration chamber, wherein the coating comprises an ultra-low attachment coating that is not derived from animal sources.
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