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公开(公告)号：US20210047644A1
公开(公告)日：2021-02-18
申请号：US16943800
申请日：2020-07-30
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US10888613B2
公开(公告)日：2021-01-12
申请号：US16076655
申请日：2017-01-11
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen
IPC: A61K39/21 , A61K39/12 , C12N15/113 , C12N15/867 , C12N15/86 , A61K39/00
Abstract: The present invention relates generally to immunotherapy for preventing HIV infection in HIV-negative individuals. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US10767183B2
公开(公告)日：2020-09-08
申请号：US16083384
申请日：2017-03-09
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US20200063161A1
公开(公告)日：2020-02-27
申请号：US16563738
申请日：2019-09-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US10233464B2
公开(公告)日：2019-03-19
申请号：US16011550
申请日：2018-06-18
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Jeff Galvin
IPC: A61K48/00 , A61K9/127 , C07K14/47 , C12N15/85 , C12N15/11 , C12N15/86 , C12N7/00 , A61K39/39 , A61K35/14 , C12N15/113 , C12N5/078 , A61P31/18 , A61K35/12 , A61K39/00 , A61K35/15 , A61K39/12
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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Patent Agency Ranking
公开(公告)号：US20190062786A1
公开(公告)日：2019-02-28
申请号：US16182443
申请日：2018-11-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113 , A61K31/675 , A61K48/00 , A61K39/00 , C12N5/00
CPC classification number: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , A61K48/00 , A61K2039/5158 , C12N5/00 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US20190046633A1
公开(公告)日：2019-02-14
申请号：US16076655
申请日：2017-01-11
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen
IPC: A61K39/21
Abstract: The present invention relates generally to immunotherapy for preventing HIV infection in HIV-negative individuals. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US20180291399A1
公开(公告)日：2018-10-11
申请号：US16011550
申请日：2018-06-18
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Jeff Galvin
IPC: C12N15/86 , C12N15/113 , A61K35/14 , A61K39/39 , C12N5/078 , C12N7/00 , A61P31/18 , A61K39/00 , A61K35/12 , A61K35/15 , A61K39/12
CPC classification number: C12N15/86 , A61K35/14 , A61K35/15 , A61K39/12 , A61K39/39 , A61K2035/124 , A61K2039/55561 , A61P31/18 , C12N5/0634 , C12N7/00 , C12N15/1132 , C12N15/1138 , C12N2310/141 , C12N2320/32 , C12N2330/51 , C12N2510/00 , C12N2740/15021 , C12N2740/15034 , C12N2740/15043 , C12N2740/15052
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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公开(公告)号：US20180256624A1
公开(公告)日：2018-09-13
申请号：US15904131
申请日：2018-02-23
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , A61P35/02 , A61K31/675 , A61K47/68 , A61K47/69
CPC classification number: A61K31/7105 , A61K31/675 , A61K47/6807 , A61K47/6901 , A61K2300/00 , A61P35/02
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US10036038B2
公开(公告)日：2018-07-31
申请号：US15668223
申请日：2017-08-03
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Jeff Galvin
IPC: A61K48/00 , A61K9/127 , C12N15/85 , C07K14/47 , C07K14/535 , C12N15/86 , C12N15/113 , C12N5/078 , A61K35/14 , A61K39/39 , C12N7/00 , A61P31/18 , A61K39/00 , A61K35/12 , A61K39/12 , A61K35/15
CPC classification number: C12N15/86 , A61K35/14 , A61K35/15 , A61K39/12 , A61K39/39 , A61K2035/124 , A61K2039/55561 , A61P31/18 , C12N5/0634 , C12N5/0636 , C12N7/00 , C12N15/1132 , C12N15/1138 , C12N2310/141 , C12N2320/32 , C12N2330/51 , C12N2510/00 , C12N2740/15021 , C12N2740/15034 , C12N2740/15043 , C12N2740/15052
Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.
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