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公开(公告)号：US20230340531A1
公开(公告)日：2023-10-26
申请号：US18051821
申请日：2022-11-01
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113
CPC classification number: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , C12N5/0636 , C12N15/113 , A61K48/00
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US20230277579A1
公开(公告)日：2023-09-07
申请号：US18055525
申请日：2022-11-15
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , A61P35/02 , A61K47/68 , A61K47/69 , A61K31/675 , C12N15/113 , C12N15/86
CPC classification number: A61K31/7105 , A61P35/02 , A61K47/6807 , A61K47/6901 , A61K31/675 , C12N15/1137 , C12N15/86 , C12Y205/0101 , A61K2300/00 , C12N2310/14 , C12N2310/531 , C12N2330/51 , C12N2740/16032 , C12N2740/16043 , C12N2740/16045 , C12N2750/14143 , C12N2810/6072
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US20210047644A1
公开(公告)日：2021-02-18
申请号：US16943800
申请日：2020-07-30
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US10767183B2
公开(公告)日：2020-09-08
申请号：US16083384
申请日：2017-03-09
Inventor： Tyler Lahusen , Mei-Ling Liou , Lingzhi Xiao , Haishan Li , Charles David Pauza
IPC: C12N15/113 , C12N15/86 , A61P35/00 , C12N15/62 , C12N15/85
Abstract: A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
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公开(公告)号：US20200063161A1
公开(公告)日：2020-02-27
申请号：US16563738
申请日：2019-09-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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Patent Agency Ranking
公开(公告)号：US20190062786A1
公开(公告)日：2019-02-28
申请号：US16182443
申请日：2018-11-06
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: C12N15/86 , A61K31/7105 , A61K38/16 , C12N5/0783 , C12N15/113 , A61K31/675 , A61K48/00 , A61K39/00 , C12N5/00
CPC classification number: C12N15/86 , A61K31/675 , A61K31/7105 , A61K38/16 , A61K48/00 , A61K2039/5158 , C12N5/00 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2310/531
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US20180256624A1
公开(公告)日：2018-09-13
申请号：US15904131
申请日：2018-02-23
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , A61P35/02 , A61K31/675 , A61K47/68 , A61K47/69
CPC classification number: A61K31/7105 , A61K31/675 , A61K47/6807 , A61K47/6901 , A61K2300/00 , A61P35/02
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US11534450B2
公开(公告)日：2022-12-27
申请号：US16988427
申请日：2020-08-07
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , C12N15/113 , C12N15/86 , A61P35/02 , A61K47/68 , A61K47/69 , A61K31/675 , C12Q1/68
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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公开(公告)号：US10772905B2
公开(公告)日：2020-09-15
申请号：US16530908
申请日：2019-08-02
Inventor： Charles David Pauza , Haishan Li , Tyler Lahusen , Mei-Ling Liou
IPC: A61K31/7105 , C12N15/113 , C12N15/86 , A61K47/69 , A61P35/02 , A61K47/68 , A61K31/675
Abstract: The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
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10.发明申请公开(公告)号：US20200181645A1
公开(公告)日：2020-06-11
申请号：US16614682
申请日：2018-06-15
Inventor： Charles David Pauza , Tyler Lahusen , Haishan Li , Mei-Ling Liou , Lingzhi Xiao
Abstract: The present disclosure relates generally to methods and compositions for activating gamma-delta (GD) T cells. Such methods and compositions can be used to treat cancer.
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