公开(公告)号：US5843719A

公开(公告)日：1998-12-01

申请号：US897429

申请日：1997-07-21

Applicant: Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer

Inventor： Susan G. Stuart ,  Phillip R. Hawkins ,  Jeffrey J. Seilhamer

IPC: G01N33/566 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C12P21/06 ,  C07H21/04 ,  C07K1/00

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (CB). The present invention also provides for antisense molecules to the nucleotide sequences which encode CB, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.

Abstract translation: 本发明提供了鉴定和编码新型纤维连翘蛋白（CB）的核苷酸和氨基酸序列。 本发明还提供编码CB的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主 用于表达CB的细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化，发炎或患病细胞和/或组织的诊断测试。

公开(公告)号：US5843665A

公开(公告)日：1998-12-01

申请号：US741437

申请日：1996-10-31

Applicant: Phillip R. Hawkins ,  Jennifer L. Hillman

Inventor： Phillip R. Hawkins ,  Jennifer L. Hillman

IPC: A61P29/00 ,  A61P35/00 ,  C12N9/14 ,  C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC classification number: C12N9/14

Abstract: The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.

公开(公告)号：US5783669A

公开(公告)日：1998-07-21

申请号：US700178

申请日：1996-08-20

Applicant: Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

Inventor： Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

IPC: G01N33/566 ,  C07K14/705 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68

CPC classification number: C07K14/705

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode the hyaluronan receptor (hr) from human umbilical vein endothelial cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode hr, expression vectors for the production of purified HR, antibodies capable of binding specifically to HR, hybridization probes or oligonucleotides for detecting the upregulation of HR encoding nucleotide sequences, genetically engineered host cells for the expression of HR, diagnostic tests for activated, angiogenic, inflamed or metastatic cells and/or tissues based on HR-encoding nucleic acid molecules and antibodies capable of binding specifically to the receptor.

Abstract translation: 本发明提供鉴定和编码人脐静脉内皮细胞的透明质酸受体（hr）的核苷酸和氨基酸序列。 本发明还提供编码hr的核苷酸序列的反义分子，用于产生纯化的HR的表达载体，能够特异性结合HR的抗体，用于检测HR编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主 用于表达HR的细胞，基于编码HR的核酸分子和能够特异性结合受体的抗体的活化的，血管生成的，发炎的或转移性细胞和/或组织的诊断测试。

公开(公告)号：US5648239A

公开(公告)日：1997-07-15

申请号：US667679

申请日：1996-06-21

Applicant: Phillip R. Hawkins ,  Jennifer L. Hillman ,  Janice Au-Young

Inventor： Phillip R. Hawkins ,  Jennifer L. Hillman ,  Janice Au-Young

IPC: G01N33/53 ,  A61K31/711 ,  A61K38/00 ,  A61K38/55 ,  A61K39/395 ,  A61K48/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C12N15/00 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85

CPC classification number: C07K14/4703 ,  A61K38/00

Abstract: The present invention provides a polynucleotide (ipka) which identifies and encodes a novel human cAMP-dependent protein kinase A inhibitor homolog (IPKA). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKA.

Abstract translation: 本发明提供鉴定和编码新的人cAMP依赖性蛋白激酶A抑制剂同源物（IPKA）的多核苷酸（ipka）。 本发明提供了包含编码IPKA的核酸序列的基因工程表达载体和宿主细胞。

公开(公告)号：US5587306A

公开(公告)日：1996-12-24

申请号：US419078

申请日：1995-04-10

Applicant: Phillip R. Hawkins ,  Jeffrey J. Seilhamer

Inventor： Phillip R. Hawkins ,  Jeffrey J. Seilhamer

IPC: G01N33/53 ,  A61K31/70 ,  A61K38/00 ,  A61K38/46 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07K16/40 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N15/09 ,  C12N15/54 ,  C12N15/55 ,  C12P21/08 ,  C12N9/20 ,  C12N15/70

CPC classification number: C12N9/16 ,  A61K38/52 ,  C12Y503/04001

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel phospholipase C homolog (plch and PLCH). The present invention also provides for antisense molecules to the plch nucleotide sequences, expression vectors for the production of purified PLCH, antibodies capable of binding specifically to PLCH, hybridization probes or oligonucleotides for the detecting excess PLCH-encoding nucleotide sequences, genetically engineered host cells for the expression of PLCH, diagnostic tests for activated, inflamed, diseased, and hydroxyurea-resistant cells and/or tissues based on PLCH-encoding nucleic acid molecules and antibodies capable of binding specifically to PLCH.

Abstract translation: 本发明提供鉴定和编码新型磷脂酶C同源物（plch和PLCH）的核苷酸和氨基酸序列。 本发明还提供了针对ch核苷酸序列的反义分子，用于产生纯化的PLCH的表达载体，能够特异性结合PLCH的抗体，用于检测过量PLCH编码核苷酸序列的杂交探针或寡核苷酸，用于 PLCH的表达，基于编码PLCH的核酸分子和能够特异性结合PLCH的抗体的活化，发炎，患病和羟基脲抗性细胞和/或组织的诊断测试。

公开(公告)号：US20100279333A1

公开(公告)日：2010-11-04

申请号：US12730953

申请日：2010-03-24

Applicant: KARL J. GUEGLER ,  PHILLIP R. HAWKINS ,  CRAIG G. WILDE ,  JEFFREY J. SEILHAMER

Inventor： KARL J. GUEGLER ,  PHILLIP R. HAWKINS ,  CRAIG G. WILDE ,  JEFFREY J. SEILHAMER

IPC: C12Q1/02 ,  G01N33/68 ,  G01N33/53

CPC classification number: C07K14/522 ,  A61K38/00 ,  C12Q1/6883 ,  C12Q2600/158 ,  Y10S514/885 ,  Y10S930/14

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

Abstract translation: 本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。 本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

公开(公告)号：US07708984B2

公开(公告)日：2010-05-04

申请号：US11806846

申请日：2007-06-04

Applicant: Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

Inventor： Karl J. Guegler ,  Phillip R. Hawkins ,  Craig G. Wilde ,  Jeffrey J. Seilhamer

IPC: A61K38/19

CPC classification number: C07K14/522 ,  A61K38/00 ,  C12Q1/6883 ,  C12Q2600/158 ,  Y10S514/885 ,  Y10S930/14

Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

Abstract translation: 本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。 本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主 用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

公开(公告)号：US06365714B1

公开(公告)日：2002-04-02

申请号：US09215063

申请日：1998-12-17

Applicant: Jennifer L. Hillman ,  Phillip R. Hawkins

Inventor： Jennifer L. Hillman ,  Phillip R. Hawkins

IPC: C07K1447

CPC classification number: C07K14/4702 ,  A61K38/00

Abstract: The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.

Abstract translation: 本发明提供了人翻译调节子（TRANAC）和识别和编码TRANAC的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与TRANAC表达相关的疾病的方法。

公开(公告)号：US06232077B1

公开(公告)日：2001-05-15

申请号：US09541228

申请日：2000-04-03

Applicant: Janice Au-Young ,  Karl J. Guegler ,  Phillip R. Hawkins

Inventor： Janice Au-Young ,  Karl J. Guegler ,  Phillip R. Hawkins

IPC: C07H2104

CPC classification number: C12N9/1205 ,  A61K38/00

Abstract: The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.

Abstract translation: 本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。 本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。 此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

公开(公告)号：US6087125A

公开(公告)日：2000-07-11

申请号：US199842

申请日：1998-11-24

Applicant: Olga Bandman ,  Phillip R. Hawkins

Inventor： Olga Bandman ,  Phillip R. Hawkins

IPC: A61K38/00 ,  C12N1/21 ,  C12N9/12 ,  C12N15/11 ,  C12N15/00 ,  C12N15/63

CPC classification number: C12N9/12 ,  A61K38/00

Abstract: The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.

Abstract translation: 本发明提供鉴定和编码新型人nm23样蛋白（H-nm23）的多核苷酸。 本发明提供了遗传工程改造的表达载体和宿主细胞，其包含编码H-nm23的核酸序列和用于产生蛋白质的方法。 本发明还提供使用基本纯化的H-nm23用于治疗与H-nm23表达相关的疾病。 本发明还描述了利用包含与编码H-nm23的天然存在的序列和特异性结合蛋白的抗体杂交的多核苷酸的诊断组合物的诊断测定法。