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    CLOSED LOOP PARAMETER ADJUSTMENT FOR SENSOR MODULES OF AN IMPLANTABLE MEDICAL DEVICE
    41.
    发明申请
    CLOSED LOOP PARAMETER ADJUSTMENT FOR SENSOR MODULES OF AN IMPLANTABLE MEDICAL DEVICE 审中-公开
    可植入医疗器械传感器模块的闭环参数调整

    公开(公告)号：US20100105997A1

    公开(公告)日：2010-04-29

    申请号：US12361990

    申请日：2009-01-29

    申请人： Robert Michael Ecker ,  Kaustubh R. Patil ,  John Robert Hamilton ,  James D. Reinke ,  Timothy Davis

    发明人： Robert Michael Ecker ,  Kaustubh R. Patil ,  John Robert Hamilton ,  James D. Reinke ,  Timothy Davis

    IPC分类号： A61N1/36 ,  A61B5/1455

    CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61B5/14542 ,  A61B5/1459 ,  A61B5/7203

    摘要： In general, the invention is directed toward an implantable medical device that includes a controller and a plurality of sensor modules. The controller may control the sensor modules to perform one or more sensor actions in order to facilitate a measurement. The sensor modules may store one or more operational parameters that control various aspects of the sensor actions performed by the sensor modules. The controller may automatically adjust one or more of the operational parameters based on results received from previous measurements in order to provide closed loop parameter adjustment of the operational parameters associated with the sensor modules. The controller may communicate with the sensor modules via a common bus. Example measurements include tissue perfusion measurements, blood oxygen sensing measurements, sonomicrometry measurements, and pressure measurements.

    摘要翻译： 通常，本发明涉及可植入医疗装置，其包括控制器和多个传感器模块。 控制器可以控制传感器模块执行一个或多个传感器动作以便于测量。 传感器模块可以存储控制由传感器模块执行的传感器动作的各个方面的一个或多个操作参数。 控制器可以基于从先前测量接收的结果来自动调整一个或多个操作参数，以便提供与传感器模块相关联的操作参数的闭环参数调整。 控制器可以通过公共总线与传感器模块进行通信。 示例测量包括组织灌注测量，血氧感测测量，经济测量测量和压力测量。

    Method for automatically adjusting the sensitivity of cardiac sense amplifiers
    43.
    发明授权
    Method for automatically adjusting the sensitivity of cardiac sense amplifiers 失效
    自动调节心律放大器灵敏度的方法

    公开(公告)号：US6112119A

    公开(公告)日：2000-08-29

    申请号：US957908

    申请日：1997-10-27

    申请人： Robert J. Schuelke ,  James W. Busacker ,  James D. Reinke ,  Kevin L. Bright ,  Russell E. Anderson ,  Virginia De La Riva ,  David W. Hoffman ,  Ren Zhou

    发明人： Robert J. Schuelke ,  James W. Busacker ,  James D. Reinke ,  Kevin L. Bright ,  Russell E. Anderson ,  Virginia De La Riva ,  David W. Hoffman ,  Ren Zhou

    IPC分类号： A61N1/37 ,  A61N1/362

    CPC分类号： A61N1/3704

    摘要： Two mechanisms work together to adjust two variables independently so that the gain of an input amplifier used to find physiologic signals in an implantable medical device can be automatically adjusted to enhance the signal to noise ratio of the electrical input to said amplifier. The first determines whether there has been too long a time between senses found in the body's electrical input to the amplifier and if true, and no other conditions override that consideration, it adjusts the value of a long term average parameter which is used as a referent parameter to adjust the actual parameter that is used as the referent for making either a threshold level adjustment or gain change, depending on the structure of the particular design's circuitry and/or software. One set of adjustments to the gain referent parameter depends on the relative size of the long term average parameter and the gain referent parameter. The mechanisms preferably employ counting registers, the one which adjusts the gain referent having a process to weight input signals such that those of different types get different weights, and the other mechanism only accepting certain of the input signals. Input signals to the two mechanisms can be either physiologically based or from stimulation pulses issued from an implanted device, such as, for example a pacemaker.

    摘要翻译： 两个机构一起工作以独立地调整两个变量，使得可以自动调整用于在可植入医疗装置中发现生理信号的输入放大器的增益，以增强到所述放大器的电输入的信噪比。 第一个确定在身体对放大器的电输入中发现的感觉之间是否存在太长的时间，如果是真的，并且没有其他条件覆盖该考虑，则它调整用作指示物的长期平均参数的值 参数，以根据特定设计的电路和/或软件的结构来调整用作参考对象的实际参数以进行阈值电平调整或增益改变。 增益参数参数的一组调整取决于长期平均参数和增益指标参数的相对大小。 这些机制优选地采用计数寄存器，调整增益指示器的调试寄存器具有加权输入信号的过程，使得不同类型的信号获得不同的权重，而另一机制仅接受某些输入信号。 对两种机制的输入信号可以是生理学的，也可以是从植入装置（例如起搏器）发出的刺激脉冲。

    Low-power system clock calibration based on a high-accuracy reference clock
    46.
    发明授权
    Low-power system clock calibration based on a high-accuracy reference clock 有权
    基于高精度参考时钟的低功耗系统时钟校准

    公开(公告)号：US08825170B2

    公开(公告)日：2014-09-02

    申请号：US12915832

    申请日：2010-10-29

    申请人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

    发明人： Matthew Bond ,  Charles R. Gordon ,  Weizheng Liang ,  James D. Reinke ,  Jonathan P. Roberts

    IPC分类号： A61N1/00 ,  A61N1/08 ,  A61N1/02 ,  G06F1/12 ,  A61N1/372

    CPC分类号： A61N1/37264 ,  A61N1/025 ,  A61N1/08 ,  A61N1/372 ,  A61N1/37276 ,  G06F1/04 ,  G06F1/12

    摘要： Various techniques are described for periodically performing a calibration routine to calibrate a low-power system clock within an implantable medical device (IMD) based on a high accuracy reference clock also included in the IMD. The system clock is powered continuously, and the reference clock is only powered on during the calibration routine. The techniques include determining a clock error of the system clock based on a difference between frequencies of the system clock and the reference clock over a fixed number of clock cycles, and adjusting a trim value of the system clock to compensate for the clock error. Calibrating the system clock with a delta-sigma loop, for example, reduces the clock error over time. This allows accurate adjustment of the system clock to compensate for errors due to trim resolution, circuit noise and temperature.

    摘要翻译： 描述了各种技术，用于周期性地执行校准例程以基于也包括在IMD中的高精度参考时钟校准可植入医疗设备（IMD）内的低功率系统时钟。 系统时钟连续供电，参考时钟仅在校准程序中打开电源。 这些技术包括基于系统时钟的频率和固定数量的时钟周期上的参考时钟之间的差异来确定系统时钟的时钟误差，以及调整系统时钟的修整值以补偿时钟误差。 例如，用delta-sigma循环校准系统时钟可以减少时间误差。 这允许系统时钟的精确调整，以补偿由于调整分辨率，电路噪声和温度引起的误差。