公开(公告)号：US06277640B1

公开(公告)日：2001-08-21

申请号：US09630706

申请日：2000-07-31

Applicant: C. Frank Bennett ,  Lex M. Cowsert

Inventor： C. Frank Bennett ,  Lex M. Cowsert

IPC: C12N1563

CPC classification number: C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for inhibiting the expression of Her-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-3. Methods of using these compounds for inhibition of Her-3 expression and for treatment of diseases associated with expression of Her-3 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于抑制Her-3的表达。 组合物包含靶向编码Her-3的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物抑制Her-3表达和治疗与Her-3表达相关的疾病的方法。

公开(公告)号：US06271029B1

公开(公告)日：2001-08-07

申请号：US09428583

申请日：1999-10-27

Applicant: C. Frank Bennett ,  Lex M. Cowsert

Inventor： C. Frank Bennett ,  Lex M. Cowsert

IPC: A61K317088

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of cytohesin-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cytohesin-2. Methods of using these compounds for modulation of cytohesin-2 expression and for treatment of diseases associated with expression of cytohesin-2 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节细胞色素-2的表达。 组合物包含靶向编码细胞色素-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节细胞凋亡蛋白-2表达和治疗与细胞色素-2表达相关疾病的方法。

公开(公告)号：US06210892B1

公开(公告)日：2001-04-03

申请号：US09277020

申请日：1999-03-26

Applicant: C. Frank Bennett ,  Stanley T. Cooke ,  Muthiah Manoharan ,  Jacqueline R. Wyatt ,  Brenda F. Baker ,  Brett P. Monia ,  Susan M. Freier ,  Robert McKay ,  James G. Karras

Inventor： C. Frank Bennett ,  Stanley T. Cooke ,  Muthiah Manoharan ,  Jacqueline R. Wyatt ,  Brenda F. Baker ,  Brett P. Monia ,  Susan M. Freier ,  Robert McKay ,  James G. Karras

IPC: C12Q168

CPC classification number: C12N15/1135 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/3233 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.

Abstract translation: 本发明提供了使用不支持mRNA靶的切割的反义化合物来控制细胞，组织或生物体通过mRNA加工反义调节的行为的组合物和方法。

公开(公告)号：US6165720A

公开(公告)日：2000-12-26

申请号：US224818

申请日：1998-12-30

Applicant: Philip L. Felgner ,  Olivier Zelphati ,  C. Frank Bennett

Inventor： Philip L. Felgner ,  Olivier Zelphati ,  C. Frank Bennett

IPC: C12N15/09 ,  A61K48/00 ,  A61P43/00 ,  C07K14/00 ,  C07K14/035 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N13/00 ,  C12N15/65 ,  C12N15/67 ,  C12Q1/68 ,  C12Q1/64 ,  C07H21/00 ,  C12N15/63

CPC classification number: C12N15/67 ,  A61K48/00 ,  C07K14/003 ,  C07K14/005 ,  C12N15/65 ,  C12N2710/16622

Abstract: Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to monitoring plasmid biodistribution, promote nuclear localization, induce transcriptional activation, lyse the endosomal compartment and facilitate transfection. These complexes increase the efficiency of expression of a particular gene.

Abstract translation: 包含核酸分子和缀合肽核酸（PNA）的复合物。 PNA可以标记或缀合到蛋白质，肽，碳水化合物部分或受体配体。 这些复合物用于转染细胞以监测质粒生物分布，促进核定位，诱导转录激活，裂解内体室并促进转染。 这些复合物增加特定基因的表达效率。

公开(公告)号：US6117847A

公开(公告)日：2000-09-12

申请号：US94714

申请日：1998-06-15

Applicant: C. Frank Bennett ,  Nicholas M. Dean

Inventor： C. Frank Bennett ,  Nicholas M. Dean

IPC: A61K38/00 ,  C12N9/12 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/70 ,  C07H21/00

CPC classification number: C12N15/1137 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q1/6883 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q2600/158

Abstract: Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides are from 5 to 50 nucleotides in length and in one referred embodiment are from 12 to 18 nucleotides in length. The oligonucleotides may be chimeric oligonucleotides and in a preferred embodiment comprise at least one 2'-O-methoxyethyl modification. Pharmaceutical compositions comprising the oligonucleotides of the invention are also provided. Methods of inhibiting protein kinase C expression and methods of treating conditions associated with expression of protein kinase C using oligonucleotides of the invention are disclosed.

Abstract translation: 提供组合物和方法用于调节蛋白激酶C的表达。提供靶向编码PKC的核酸的寡核苷酸。 寡核苷酸长度为5至50个核苷酸，并且在一个所提及的实施方案中，长度为12至18个核苷酸。 寡核苷酸可以是嵌合寡核苷酸，并且在优选的实施方案中包含至少一个2'-O-甲氧基乙基修饰。 还提供了包含本发明的寡核苷酸的药物组合物。 公开了使用本发明的寡核苷酸抑制蛋白激酶C表达的方法和与蛋白激酶C的表达相关的病症的治疗方法。

公开(公告)号：US6107092A

公开(公告)日：2000-08-22

申请号：US280409

申请日：1999-03-29

Applicant: Lex M. Cowsert ,  C. Frank Bennett ,  Bert W. O'Malley

Inventor： Lex M. Cowsert ,  C. Frank Bennett ,  Bert W. O'Malley

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  C12N15/09 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582

Abstract: Antisense compounds, compositions and methods are provided for modulating the function or amount of SRA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to SRA or nucleic acids encoding SRA. Methods of using these compounds for modulation of SRA levels and for treatment of diseases associated with SRA are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节SRA的功能或量。 组合物包含靶向SRA或编码SRA的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节SRA水平和治疗与SRA相关疾病的方法。

公开(公告)号：US6077833A

公开(公告)日：2000-06-20

申请号：US777266

申请日：1996-12-31

Applicant: C. Frank Bennett ,  Timothy A. Vickers

Inventor： C. Frank Bennett ,  Timothy A. Vickers

IPC: C12N15/09 ,  A61K31/7088 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07H21/00 ,  C12N15/113 ,  C12Q1/68 ,  A61K31/70 ,  C12N5/06 ,  C07H2/00

CPC classification number: C12N15/1138 ,  A61K31/711 ,  C07H21/00 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515

Abstract: Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.

Abstract translation: 提供了用于诊断，预防和治疗适于通过调节T细胞活化治疗的免疫状态和障碍的组合物和方法。 根据优选实施方案，提供了与编码B7蛋白的核酸特异性杂交的寡核苷酸。

公开(公告)号：US6077709A

公开(公告)日：2000-06-20

申请号：US163162

申请日：1998-09-29

Applicant: C. Frank Bennett ,  Elizabeth J. Ackermann ,  Eric E. Swayze ,  Lex M. Cowsert

Inventor： C. Frank Bennett ,  Elizabeth J. Ackermann ,  Eric E. Swayze ,  Lex M. Cowsert

IPC: C07H21/04 ,  A61K31/7088 ,  A61K31/712 ,  A61K48/00 ,  A61P35/00 ,  C07H21/00 ,  C12P21/04 ,  C07H21/02 ,  C12Q1/68

CPC classification number: C07H21/00 ,  C07B2200/11

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。

公开(公告)号：US6015892A

公开(公告)日：2000-01-18

申请号：US578615

申请日：1996-01-11

Applicant: C. Frank Bennett ,  Russell T. Boggs ,  Nicholas M. Dean

Inventor： C. Frank Bennett ,  Russell T. Boggs ,  Nicholas M. Dean

IPC: C12N15/09 ,  A61K31/7088 ,  A61K31/711 ,  A61K31/712 ,  A61K31/7125 ,  A61K38/00 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/00 ,  C07H21/04 ,  C07K14/705 ,  C12N5/10 ,  C12N9/12 ,  C12N15/113 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/573 ,  G01N33/68 ,  C07H21/02 ,  C12N15/85

CPC classification number: C12N15/1137 ,  A61K48/00 ,  C07H21/00 ,  C07K14/70564 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Y207/11013 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q2600/158

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with a PKC gene or mRNA. Oligonucleotides specifically hybridizable with a particular PKC isozyme, set of isozymes or mRNA transcript are provided. Methods of treating conditions amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with a PKC gene or mRNA are disclosed. Compositions and methods are provided for the treatment, detection and diagnosis of diseases associated with protein kinase C alpha and specific transcripts thereof. New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C alpha polynucleotide probes for PKC alpha are also disclosed.

Abstract translation: PCT No.PCT / US94 / 07770 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT提交1994年7月8日PCT公布。 出版物WO95 / 02069 日期1995年1月19日提供了用于治疗和诊断与蛋白激酶C相关的疾病的组合物和方法。提供与PKC基因或mRNA特异性杂交的寡核苷酸。 提供了与特定的PKC同功酶特异性杂交的寡核苷酸，一组同功酶或mRNA转录物。 公开了通过用与PKC基因或mRNA特异性杂交的寡核苷酸调节蛋白激酶C表达来治疗适于治疗干预的病症的方法。 提供组合物和方法用于治疗，检测和诊断与蛋白激酶Cα相关的疾病及其特异性转录物。 提供了新的核酸序列，其编码编码PKCα的人蛋白激酶C 3多核苷酸探针的3'非翻译区。

公开(公告)号：US06004814A

公开(公告)日：1999-12-21

申请号：US161244

申请日：1998-09-25

Applicant: C. Frank Bennett ,  Lex M. Cowsert

Inventor： C. Frank Bennett ,  Lex M. Cowsert

IPC: C12N15/113 ,  C07H21/04 ,  C07H21/02 ,  C12N15/11

CPC classification number: C12N15/1138 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of CD71. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD71. Methods of using these compounds for modulation of CD71 expression and for treatment of diseases associated with expression of CD71 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节CD71的表达。 组合物包含靶向编码CD71的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节CD71表达和治疗与CD71表达相关的疾病的方法。