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    Induced pluripotent stem cell model for Fabry disease and use thereof
    441.
    发明授权
    Induced pluripotent stem cell model for Fabry disease and use thereof 有权

    公开(公告)号：US10287554B2

    公开(公告)日：2019-05-14

    申请号：US14839603

    申请日：2015-08-28

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Yong-mahn Han ,  Sang-Wook Park

    IPC: C12N5/074 ,  G01N33/50

    Abstract: The present invention relates to an induced pluripotent stem cell model of Fabry disease, a preparation method thereof, and a use of the same for the study of Fabry disease development and for the screening of a therapeutic agent for the disease. Particularly, Fabry disease derived induced pluripotent stem cells (iPSCs), embryoid body (EB), and vascular cells were developed and differentiated from fibroblasts originated from Fabry disease patient, wherein the Fabry disease originated iPSCs displayed significantly reduced expression and activity of GLA protein therein, compared with the normal cells, resulting in the accumulation of globotriaosylceramide (Gb3, CD77). Also, the differentiation of vascular cells was induced from the Fabry disease originated iPSCs, and as a result the iPSCs were successfully differentiated into vascular endothelial cells and vascular smooth muscle cells with significantly expressing the marker protein. When the vascular endothelial cells and vascular smooth muscle cells were treated with Fabrazyme, the accumulation of Gb3 was significantly reduced, suggesting that the said cell model can be effectively used for the analysis/study of Fabry disease outbreak mechanism and for the screening of a therapeutic agent for the disease.

    Polypeptide for binding to complement protein C5A, and use of same
    442.
    发明授权
    Polypeptide for binding to complement protein C5A, and use of same 有权

    公开(公告)号：US10287342B2

    公开(公告)日：2019-05-14

    申请号：US15500921

    申请日：2015-08-03

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jung-Min Choi ,  Joong-Jae Lee ,  Woosung Heu

    IPC: A61K39/00 ,  A61K39/02 ,  C07H21/04 ,  C07K16/18 ,  C12N15/62 ,  C07K14/725 ,  C07K14/34 ,  A61K38/00

    Abstract: The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide which can be bound to a complement protein C5a and inhibit the activation of same, polynucleotide which codes for the polypeptide, a recombinant vector which comprises the polynucleotide, a recombinant microorganism to which the recombinant vector has been introduced, a method for producing the polypeptide by means of the recombinant microorganism, and a pharmaceutical composition, for treating immune diseases or sepsis, containing the polypeptide. A polypeptide, according to the present invention, can be bound to a complement protein C5a, with higher affinity compared to being bound to a complement protein C5a receptor which is present in nature, and inhibits the activation of same, thus being widely utilized for development of formulation for preventing or treating diseases related to a complement protein C5a.

    Method and system for simultaneously measuring surface normal vector and surface reflectance function in microscale
    443.
    发明授权
    Method and system for simultaneously measuring surface normal vector and surface reflectance function in microscale 有权

    公开(公告)号：US10281396B2

    公开(公告)日：2019-05-07

    申请号：US15427821

    申请日：2017-02-08

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： MinHyuk Kim ,  Giljoo Nam ,  Joo Ho Lee

    IPC: G01N21/55 ,  G02B21/26 ,  G02B21/06 ,  G01B11/24

    Abstract: Disclosed is a system for simultaneously measuring a surface normal vector and a surface reflection function in microscale. The system includes a light dome having a hemispherical-shaped structure and including LEDs to radiate light to an object placed therein; a macro lens installed camera arranged over the light dome to photograph the object through a hole formed at a center of the light dome under an environment in which a light is radiated from the light dome; an xyz micro-translation stage arranged under the light dome and configured to move in xyz-directions to adjust a focal distance between the macro lens installed camera and the object, and a measurement unit configured to control the light dome and the macro lens installed camera to obtain a microscale image, and configured to simultaneously measure a surface normal vector and a surface reflection function of the object based on the microscale image.

    Gas sensor and member using metal oxide semiconductor nanofibers including nanoparticle catalyst functionalized by bifunctional nano-catalyst included within apoferritin, and manufacturing method thereof
    444.
    发明授权
    Gas sensor and member using metal oxide semiconductor nanofibers including nanoparticle catalyst functionalized by bifunctional nano-catalyst included within apoferritin, and manufacturing method thereof 有权

    公开(公告)号：US10274467B2

    公开(公告)日：2019-04-30

    申请号：US14855975

    申请日：2015-09-16

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Ii-Doo Kim ,  Sang-Joon Kim ,  Seon-Jin Choi

    IPC: G01N31/10 ,  D01D5/00 ,  D01F9/10 ,  B82Y30/00 ,  C04B35/622

    Abstract: The inventive concepts relate to a member for a gas sensor, a gas sensor using the same and a manufacturing method thereof, and more particularly, to a member for a gas sensor using a one-dimensional metal oxide nanofiber complex material containing hetero nanoparticle catalysts synthesized using apo-ferritins, a gas sensor using the same, and a manufacturing method thereof.According to embodiments of the inventive concepts, apo-ferritins containing hetero nanoparticle catalysts are mixed with an electrospinning solution, the mixture solution is electrospun to form complex nanofibers, and then a high-temperature thermal treatment process is performed to remove the apo-ferritins. Thus, the hetero nanoparticle catalysts are uniformly fastened to an inside and a surface of one-dimensional metal oxide nanofibers to form a member for a gas sensor. As a result, the member for a gas sensor has a high-sensitivity characteristic capable of sensing a very small amount of a gas and excellent selectivity capable of sensing various gases. In addition, a catalyst effect is maximized by the hetero nanoparticle catalysts uniformly distributed without aggregation. Furthermore, the member for a gas sensor and the gas sensor using the same can be mass-produced by a process method capable of effectively forming pores and of fastening high-performance catalysts.

    METHOD AND SYSTEM FOR DIGITAL-ANALOG HYBRID BEAMFORMING IN MILLIMETER WAVE DOWNLINK CHANNEL
    445.
    发明申请
    METHOD AND SYSTEM FOR DIGITAL-ANALOG HYBRID BEAMFORMING IN MILLIMETER WAVE DOWNLINK CHANNEL 审中-公开

    公开(公告)号：US20190109629A1

    公开(公告)日：2019-04-11

    申请号：US16209439

    申请日：2018-12-04

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Hyuncheol PARK ,  Girim KWON

    IPC: H04B7/06 ,  H04B7/08 ,  H04B7/0456 ,  H04B17/336

    Abstract: Disclosed is a method and system for digital-analog hybrid beamforming in a millimeter wave downlink channel. A hybrid beamforming method in a downlink channel with respect to at least one user terminal belonging to a transmission apparatus includes receiving feedback information from each of the at least one user terminal; selecting at least one user terminal for transmitting a transmission signal based on the received feedback information; performing digital beamforming with respect to the selected at least one user terminal; and performing analog beamforming with respect to the selected at least one user terminal based on a prestored codebook. The codebook includes a desired number of subsets calculated based on a number of transmit antennas and a number of radio frequency (RF) chains, and each of the subsets includes a number of beamforming vectors corresponding to the number of RF chains.

    SELF-GENERATION SENSOR DEVICE AND SELF-GENERATION SENSOR SYSTEM USING THE SAME
    447.
    发明申请
    SELF-GENERATION SENSOR DEVICE AND SELF-GENERATION SENSOR SYSTEM USING THE SAME 审中-公开

    公开(公告)号：US20190081223A1

    公开(公告)日：2019-03-14

    申请号：US16083460

    申请日：2018-03-13

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  TEGWAY CO., LTD.

    Inventor： Byung Jin CHO ,  Yongjun KIM ,  Choong Sun KIM ,  Kyoung Soo YI

    IPC: H01L35/04 ,  H01L35/24

    Abstract: A self-generation sensor device and a self-generation sensor system using the same are disclosed. According to one embodiment, the self-generation sensor device may include: a sensor unit; a communication unit configured to transmit data reflecting a sensed value of the sensor unit; and a thermal power generation module including a pair of main surfaces including a high-temperature surface thermally connected to the high-temperature object and a low-temperature surface which is a surface opposite to the high-temperature surface, a thermoelectric module including a plurality of thermoelectric elements disposed between the pair of main surfaces and producing the power by using a temperature difference between the both main surfaces due to the high-temperature object, and a support member filled in a space between the both main surfaces to support the thermoelectric elements, and a heat dissipation member connected to the low-temperature surface.

    Communication apparatus and method using random access procedure
    448.
    发明授权
    Communication apparatus and method using random access procedure 有权

    公开(公告)号：US10231196B2

    公开(公告)日：2019-03-12

    申请号：US15502857

    申请日：2016-02-23

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Dan Keun Sung ,  Han Seung Jang ,  Su Min Kim

    IPC: H04W74/08 ,  H04W52/60 ,  H04W52/14 ,  H04L25/00 ,  H04J13/00 ,  H04W52/16

    Abstract: User equipment (UE) that includes a processor and that executes a random access procedure with a base station (E-UTRAN Node B (eNodeB), also known as Evolved Node B) is provided. The UE can at least temporarily be embodied by the processor. The UE may comprise: a determination unit for determining a message size that can be transmitted and that corresponds to a physical random access channel according to an assigned communication method with the base station; a calculation unit for configuring a message to correspond to the message size and for respectively calculating a preamble index and at least one message index from the message; and an encoder for providing respective encoding of the preamble index and the at least one message index, and transmitting the same to the base station.

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