公开(公告)号：US11268978B2

公开(公告)日：2022-03-08

申请号：US16583269

申请日：2019-09-26

Applicant: National Institute of Metrology, China

Inventor： Zhen-Dong Zhu ,  Si-Tian Gao ,  Wei Li ,  Shi Li ,  Jing-Tao Xu

IPC: G01J3/02 ,  G01Q70/10 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/44 ,  G01J3/12

Abstract: The present disclosure provides a tip-enhanced Raman spectroscope system. The system includes a laser emitting unit, a laser excitation unit, a first dichroic beam splitter, a first Raman spectrometer, and a confocal detecting unit. The laser excitation unit includes a sample stage and a first scanning probe. The sample stage is configured to have a sample disposed thereon such that a first incident laser beam emitted from the laser emitting unit is transmitted to the sample to excite first scattered light. The first dichroic beam splitter is configured to split a first Raman scattered light from the first Rayleigh scattered light. The first Raman spectrometer is disposed on a first Raman optical path of the first Raman scattered light. The confocal detecting unit is disposed on a first Rayleigh optical path of the first Rayleigh scattered light to image the sample.

公开(公告)号：US11241156B2

公开(公告)日：2022-02-08

申请号：US17135233

申请日：2020-12-28

Applicant: Omni Medsci, Inc.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  A61C19/04 ,  G16Z99/00 ,  G16H40/67 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  H01S3/067 ,  H01S3/00 ,  A61C1/00 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/30

Abstract: A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.

公开(公告)号：US20220011218A1

公开(公告)日：2022-01-13

申请号：US17294139

申请日：2019-11-15

Applicant: Chemitec S.r.l.

Inventor： Filippo CATELANI

IPC: G01N21/31 ,  G01J3/02 ,  G01J3/12

Abstract: A system and method for the spectrophotometric analysis of a sample of a liquid solution while it flows in a duct. The method determines the luminous intensity (Iin) of a substantially monochromatic beam based on the cleaning state of a measurement chamber and/or ageing of at least one emitting device and/or ageing of at least one detecting device, whereby the worse is the cleaning state of the measurement chamber and/or the greater is the ageing state of the at least one emitting device and/or the at least one detecting device, the higher the luminous intensity (Iin) of the substantially monochromatic beam.

公开(公告)号：US11209314B2

公开(公告)日：2021-12-28

申请号：US17126118

申请日：2020-12-18

Applicant: Government of the United States of America, as represented by the Secretary of Commerce

Inventor： Adam Joseph Fleisher ,  Keith Alan Gillis ,  Joseph Terence Hodges

IPC: G01N21/00 ,  G01J3/433 ,  G01J3/12 ,  G01J3/10 ,  G01J3/02

Abstract: A cavity buildup dispersion spectrometer includes a shutter that modulates coherent electromagnetic radiation at a shutter frequency; and produces modulated electromagnetic radiation; a frequency shifter that frequency shifts the modulated electromagnetic radiation to a shifter frequency and produces frequency shifted radiation; a resonator that produces cavity radiation from the frequency shifted radiation and the coherent electromagnetic radiation, receives an analyte; subjects the analyte to cavity radiation, and transmits the cavity radiation as transmitted electromagnetic radiation; and a receiver that: produces a detector signal from the transmitted electromagnetic radiation, such that the detector signal includes a beat frequency that corresponds to a change in a motion of resonator that includes a change in the distance between the mirrors or a change of refractive index of the analyte in the intracavity space.

公开(公告)号：US11160455B2

公开(公告)日：2021-11-02

申请号：US17078771

申请日：2020-10-23

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G16H40/67 ,  G06F19/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/88 ,  G01N33/02 ,  G01N33/15 ,  G01N33/44 ,  G01N33/49 ,  G01J3/18 ,  G01J3/12 ,  G01M3/38 ,  G01N21/85 ,  G01N21/95 ,  H01S3/00 ,  H01S3/067 ,  H01S3/30

Abstract: A system for measuring one or more physiological parameters is provided with a wearable device that includes a light source comprising a driver and a plurality of semiconductor sources that generate an output optical light. The wearable device comprises: one or more lenses to receive at least a portion of the output optical light and to deliver a lens output light to tissue, and a detection system to receive at least a portion of the lens output light reflected from the tissue and to generate an output signal having a signal-to-noise ratio, and to be synchronized to the light source. The detection system comprises at least one analog to digital converter coupled to at least one spatially separated detector. The plurality of semiconductor sources comprises six light emitting diodes, and wherein the plurality of semiconductor sources and the plurality of spatially separated detectors are located on one or more arcs.

公开(公告)号：US11159750B2

公开(公告)日：2021-10-26

申请号：US16844908

申请日：2020-04-09

Applicant: Hypermed Imaging, Inc.

Inventor： Mark Anthony Darty ,  Michael Tilleman ,  Peter Meenen ,  Dmitry Yudovsky

IPC: H04N5/33 ,  G01J3/02 ,  G01J3/10 ,  G01J3/36 ,  H04N5/225 ,  H04N5/235 ,  G01J3/28 ,  G01J3/12

Abstract: Provided are methods and systems for concurrent imaging at multiple wavelengths. In one aspect, a hyperspectral/multispectral imaging device includes a lens configured to receive light backscattered by an object, a plurality of photo-sensors, a plurality of bandpass filters covering respective photo-sensors, where each bandpass filter is configured to allow a different respective spectral band to pass through the filter, and a plurality of beam splitters in optical communication with the lens and the photo-sensors, where each beam splitter splits the light received by the lens into a plurality of optical paths, each path configured to direct light to a corresponding photo-sensor through the bandpass filter corresponding to the respective photo-sensor.

公开(公告)号：US11150134B2

公开(公告)日：2021-10-19

申请号：US17136438

申请日：2020-12-29

Applicant: CANON KABUSHIKI KAISHA

Inventor： Kazumi Kimura

IPC: G01J3/28 ,  G01J3/02 ,  H04N5/33 ,  G01J3/12

Abstract: The spectral information acquisition system includes an illumination optical system configured to illuminate an object being moved and a spectral optical system configured to disperse light from the object illuminated by the illumination optical system. The illumination optical system includes a separation element configured to separate a light flux emitted from a light source into a first polarized light flux having a first polarization state and a second polarized light flux having a second polarization state, and a phase plate configured to change the polarization state of at least one of the first polarized light flux and the second polarized light flux. The first polarized light flux illuminates the object from a first direction, and the second polarized light flux illuminates the object from a second direction that is different from the first direction.

公开(公告)号：US20210318171A1

公开(公告)日：2021-10-14

申请号：US17354948

申请日：2021-06-22

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： YASUHISA INADA ,  ATSUSHI ISHIKAWA

IPC: G01J3/28 ,  G02B5/20 ,  G02B5/28 ,  H04N5/232 ,  G01J3/12

Abstract: An optical filter includes a filter array including filters two-dimensionally arrayed and a band-pass filter. The filters includes first and second filters. A transmission spectrum of each of the first and second filters has local maximum values of transmittance at three or more wavelengths included in a first wavelength region. The band-pass filter passes light in a second wavelength region including two or more wavelengths of the three or more wavelengths and not including one or more wavelengths of the three or more wavelengths. The filter array and the band-pass filter are disposed so that (a) the band-pass filter is located on an optical path of light that passes through the first and second filters or (b) the first and second filters are located on an optical path of light that passes through the band-pass filter.

公开(公告)号：US20210310942A1

公开(公告)日：2021-10-07

申请号：US14636924

申请日：2015-03-03

Applicant: PIETRO FIORENTINI S.P.A.

Inventor： Robert Jones ,  Matthew James Hayes ,  Paul David Ryder

IPC: G01N21/3577 ,  G01N21/359 ,  G01N11/04 ,  G01J3/42 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12

Abstract: A device for determining the composition of a mixture of fluids that flow along a pipe includes: a radiation source for illuminating the mixture with radiation; a detector for detecting radiation that has been attenuated by the mixture; and a device for monitoring the flow rate of fluid along the pipe and outputting a signal indicative of the flow rate. The device for determining further includes a device for adjusting the intensity of radiation emitting by the radiation source in response to the signal indicative of the flow rate so that the intensity of the radiation source is reduced if the flow rate reduces.

公开(公告)号：US11137286B2

公开(公告)日：2021-10-05

申请号：US15888754

申请日：2018-02-05

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Kyungsang Cho

IPC: G01J3/02 ,  G01J3/28 ,  G02B5/20 ,  G01J3/51 ,  G01J3/12

Abstract: Provided are a filter array, a spectral detector including the filter array, and a spectrometer employing the spectral detector. The filter array may have a multi-array structure including a plurality of filter arrays. The filter array may include a first filter array having a first structure in which a plurality of first filters with different transmittance spectrums are arranged, and a second filter array having a second structure in which a plurality of second filters with different transmittance spectrums are arranged, the second filter array being arranged to at least partially overlap the first filter array at a first position relative to the first filter array so that the multi-arrangement type filter array has a first set of absorbance characteristics. The second filter array may be configurable to be arranged to at least partially overlap the first filter array at a second position relative to the first filter array so that the multi-arrangement type filter array has a second set of absorbance characteristics different from the first set of absorbance characteristics.