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164 条记录 (耗时 0.019 秒)

    Contrast agents and compositions for radiological imaging, and radiological imaging method utilizing same
    36.
    发明授权
    Contrast agents and compositions for radiological imaging, and radiological imaging method utilizing same 失效
    用于放射成像的对比剂和组合物，以及利用其的放射性成像方法

    公开(公告)号：US5545397A

    公开(公告)日：1996-08-13

    申请号：US341767

    申请日：1994-11-18

    申请人： Bernard F. Spielvogel ,  Dominique Meyer

    发明人： Bernard F. Spielvogel ,  Dominique Meyer

    IPC分类号： A61K49/04 ,  C01B35/06 ,  C07C215/10 ,  C07F5/02 ,  C07F9/06 ,  C07F9/535 ,  C07F9/6581 ,  C08G79/00 ,  A61K33/18

    CPC分类号： C07F9/067 ,  A61K49/0433 ,  C01B35/06 ,  C07C215/10 ,  C07F5/022 ,  C07F9/5357 ,  C07F9/65812 ,  C08G79/00

    摘要： Contrast agent for X-ray imaging, consisting of a halogenated, especially iodinated or brominated, derivative of boron, having characteristics necessary for its use in X-ray imaging. The contrast agent may be used for imaging a corporeal situs by radiological techniques, comprising delivery to the corporeal situs of an imagingly effectively amount of a physiologically acceptable composition comprising the boron reagent. A variety of illustrative boron reagents is described, including vectorised boron derivatives, e.g., boron derivatives encapsulated within liposomes, fixed on or bonded to macromolecules or polymers, etc. The contrast agents, formulations, and method of the present invention may be employed for a wide variety of radiological imaging applications, e.g., excretory urography, angiocardiography, aortography, etc.

    摘要翻译： 用于X射线成像的对比剂，由卤化的，特别是碘化或溴化的硼衍生物组成，具有其用于X射线成像所必需的特性。 造影剂可以用于通过放射学技术对体质部位进行成像，包括将成像有效量的包含硼试剂的生理上可接受的组合物输送到体内部位。 描述了各种说明性的硼试剂，包括载体化的硼衍生物，例如包封在脂质体内的硼衍生物，固定在大分子或聚合物上或结合到大分子或聚合物上等。本发明的造影剂，制剂和方法可用于 各种各样的放射成像应用，例如排泄泌尿道造影，血管造影，动脉造影等。

    Oxidation-resistant cyclophosphazene fluid including triarylphosphine or phosphine oxide
    37.
    发明授权
    Oxidation-resistant cyclophosphazene fluid including triarylphosphine or phosphine oxide 失效
    包含三芳基膦或氧化膦的抗氧化环磷腈流体

    公开(公告)号：US5194652A

    公开(公告)日：1993-03-16

    申请号：US891378

    申请日：1992-05-29

    申请人： Bassam S. Nader

    发明人： Bassam S. Nader

    IPC分类号： C07F9/6581 ,  C10M169/04

    CPC分类号： C10M169/04 ,  C07F9/65814 ,  C10M2223/003 ,  C10M2223/023 ,  C10M2223/04 ,  C10M2223/0405 ,  C10M2223/042 ,  C10M2223/0495 ,  C10M2223/06 ,  C10M2223/0603 ,  C10M2223/061 ,  C10M2223/083 ,  C10M2223/103 ,  C10N2240/08

    摘要： The oxidation resistance of a cyclophosphazene-based fluid (such as a lubricant or a hydraulic fluid) can be improved by the addition to the fluid of an oxidation-inhibiting amount of an aryl phosphine or phosphine oxide. The aryl phosphine or phosphine oxide is preferably present in an amount of about 0.01 to about 5 percent by weight. The aryl phosphine or phosphine oxide can be (a) a symmetric triarylphosphine of formula R.sub.3 P, wherein R is 4-trifluoromethyl phenyl, 3-trifluoromethyl phenyl, 3-trifluoromethoxy phenyl, 3-(3-trifluoromethylphenoxy) phenyl, 3-(perfluoro-2, 5-dimethyl-3, 6-dioxanonyl) phenyl or 1-naphthyl; (b) an oxide of any of these symmetric triarylphosphines; or (c) 1, 3-bis(diphenylphosphino) benzene. The cyclophosphazene fluid component is preferably a (fluorinated phenoxy) (3-perfluoroalkylphenoxy)-cyclic phosphazene of the general formula (I): ##STR1## wherein n is 3 to 7, inclusive; wherein R is individually in each occurrence fluorinated phenoxy or 3-perfluoroalkylphenoxy; and wherein the ratio of fluorinated phenoxy to 3-perfluoroalkylphenoxy is about 1:5 to 1:1 inclusive. Although useful as antioxidants in other fluids such as polyphenyl ethers, perfluorinated aliphatic polyethers and polyol esters, the antioxidant activity of the defined aryl phosphines and phosphine oxides in cyclophosphazene fluids is unexpected because of the significant difference in the pathways of oxidative degradation between the cyclophosphazenes and these other fluids.

    摘要翻译： 通过添加到氧化抑制量的芳基膦或氧化膦的流体，可以改善环磷腈系流体（如润滑剂或液压油）的抗氧化性。 芳基膦或氧化膦优选以约0.01至约5重量％的量存在。 芳基膦或氧化膦可以是（a）式R3P的对称三芳基膦，其中R是4-三氟甲基苯基，3-三氟甲基苯基，3-三氟甲氧基苯基，3-（3-三氟甲基苯氧基）苯基，3-（全氟 - 2,5-二甲基-3,6-二恶烷基）苯基或1-萘基; （b）这些对称三芳基膦中的任何一种的氧化物; 或（c）1,3-双（二苯基膦基）苯。 环磷腈流体组分优选为通式（I）的（氟化苯氧基）（3-全氟烷基苯氧基） - 环磷腈：其中n为3至7，包括端值; 其中R各自单独出现氟化苯氧基或3-全氟烷基苯氧基; 并且其中氟化苯氧基与3-全氟烷基苯氧基的比例为约1:5至1:1。 尽管在其他流体如聚苯醚，全氟化脂族聚醚和多元醇酯中的抗氧化剂是有用的，但是定义的芳基膦和氧化膦在环磷腈流体中的抗氧化活性是出人意料的，因为环磷腈与环氧磷腈之间的氧化降解途径有显着的差异 这些其他液体。

    Process for preparing phosphonitrile compound having substituted hydroxyl group
    39.
    发明授权
    Process for preparing phosphonitrile compound having substituted hydroxyl group 失效
    制备具有取代羟基的磷腈化合物的方法

    公开(公告)号：US4864048A

    公开(公告)日：1989-09-05

    申请号：US82336

    申请日：1987-08-06

    申请人： Masaharu Kaneko ,  Kazuhiko Fujikawa ,  Tetsuhiko Okamoto

    发明人： Masaharu Kaneko ,  Kazuhiko Fujikawa ,  Tetsuhiko Okamoto

    IPC分类号： C07F9/22 ,  C07F9/06 ,  C07F9/6581 ,  C07F9/6593 ,  C08G79/02

    CPC分类号： C07F9/067 ,  C08G79/025

    摘要： A process for preparing a phosphonitrile compound having a substituted hydroxyl group by making use of a phosphonitrile chloride oligomer and an alcohol as the starting materials, which comprises:(1) a first step of reacting said phosphonitrile chloride oligomer with said alcohol in a specific amount ratio of the active chlorine contained in said phosphonitrile chloride oligomer relative to the alcohol in the presence of a specific amount of a tertiary amine at a specific temperature, thereby substituting a specific amount of said active chlorine by a substituted alkoxy group,(2) a second step of elevating the temperature of the reaction mixture obtained in the first step to a specific temperature to cause a condensation reaction through the elimination of R--Cl, and(3) a third step of adding an alcohol in a specific amount ratio relative to said active chlorine which remains at the stage of completion of the second step, to the reaction system, and making said remaining active chlorine react with said alcohol while supplying ammonia in a specific amount ratio or more relative to the amount of said active chlorine which has been originally contained in said phosphonitrile chloride oligomer into the reaction system, thereby substantially completely and substituting said remaining active chlorine by a substituted hydroxyl group.

    摘要翻译： 通过使用磷腈氯化物低聚物和醇作为起始原料制备具有取代羟基的磷腈化合物的方法，其包括：（1）使所述磷腈氯化物低聚物与所述醇反应的第一步骤， 在特定温度下，在特定量的叔胺存在下，所述磷腈氯化物低聚物中所含的活性氯相对于醇的比例，通过取代的烷氧基取代特定量的所述活性氯，（2） 将第一步骤中获得的反应混合物的温度升高到特定温度以通过消除R-Cl引起缩合反应的第二步骤，和（3）第三步骤，相对于 所述活性氯在第二步骤完成阶段保持在反应体系中，并制备所述剩余的活性氯 与所述醇反应，同时相对于最初含在所述磷腈氯化物低聚物中的所述活性氯的量与特定量的比例供应氨，从而基本上完全用替代的所述残留的活性氯代替 羟基。