公开(公告)号：US20020131901A1

公开(公告)日：2002-09-19

申请号：US10109687

申请日：2002-04-01

申请人： BRITISH GAS PLC

发明人： Andrew Paul Monkman ,  Michael Charles Petty ,  Napolean Enompagu Agbor ,  Margaret Teresa Scully

IPC分类号： G01N007/00 ,  B32B027/04 ,  B32B005/02 ,  G01N021/00 ,  G01N027/00 ,  G01N031/00 ,  B32B027/12 ,  G01N033/00 ,  G01N027/04

CPC分类号： G01N27/126 ,  Y10T436/17 ,  Y10T436/177692 ,  Y10T436/179228

摘要： A gas sensor for use in monitoring gases such as H2S, NO2 or SO2 comprises a film or layer of non-protonated polyaniline as the gas sensing material.

摘要翻译： 用于监测气体如H 2 S，NO 2或SO 2的气体传感器包括作为气体传感材料的非质子化聚苯胺的膜或层。

公开(公告)号：US20020106306A1

公开(公告)日：2002-08-08

申请号：US09737518

申请日：2000-12-15

发明人： Da Yu Wang ,  Raymond L. Bloink ,  Frederick L. Kennard ,  Lone-Wen F. Tai ,  Eric J. Detwiler ,  Walter J. Symons ,  Paul C. Kikuchi ,  Lora Younkman

IPC分类号： G01N001/22

CPC分类号： G01N33/0037 ,  G01N1/2252 ,  G01N27/4074 ,  Y02A50/245 ,  Y10T436/177692 ,  Y10T436/179228

摘要： A gas sensor for sensing NOx having electrochemical cells wherein dielectric material surrounds electrolytes except where electrodes are attached. Thereby, the exhaust gas is effectively prevented from contacting the electrolytes of the sensor's electrochemical cells. With the use of this technique, signal cross talk is minimized while enhancing NOx sensing sensitivity. Further, the total number electrodes needed are reduced which allows for more complex sensors structures.

摘要翻译： 一种用于感测具有电化学电池的NOx的气体传感器，其中电介质材料围绕除了电极附接的电解质。 由此，能够有效地防止废气与传感器的电化学电池的电解液接触。 通过使用这种技术，信号串扰最小化，同时增强了NOx感测灵敏度。 此外，所需的总电极数量减少，这允许更复杂的传感器结构。

公开(公告)号：US20020102744A1

公开(公告)日：2002-08-01

申请号：US09984345

申请日：2001-10-29

发明人： Solomon H. Snyder ,  Samic R. Jaffrey

IPC分类号： G01N033/537

CPC分类号： G01N33/6842 ,  G01N33/6803 ,  G01N33/6815 ,  Y10T436/13 ,  Y10T436/170769 ,  Y10T436/177692 ,  Y10T436/24

摘要： Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain nitrosothiols involves several steps. Nitrosylated cysteines are converted to tagged cysteines. Tagged proteins can then be detected, for example, by immunoblotting and/or can be purified by affinity chromatography. The method is applicable to the detection of S-nitrosylated proteins in cell lysates following in vitro S-nitrosylation, as well as to the detection of endogenous S-nitrosothiols in selected protein substrates.

摘要翻译： 一氧化氮的许多作用是通过半胱氨酸残基的直接修饰来介导的，导致称为亚硝基硫醇的加合物。 检测含有亚硝基硫醇的蛋白质的方法涉及几个步骤。 将亚硝基化的半胱氨酸转化为标记的半胱氨酸。 然后可以例如通过免疫印迹和/或可以通过亲和层析纯化标记的蛋白质。 该方法适用于在体外S-亚硝基化后检测细胞裂解物中的S-亚硝基化蛋白质，以及在所选蛋白质底物中检测内源性S-亚硝基硫醇。

公开(公告)号：US20010042843A1

公开(公告)日：2001-11-22

申请号：US09774157

申请日：2001-01-29

发明人： Richard Anthony Cox ,  Roderic Lewis Jones

IPC分类号： G01J001/00

CPC分类号： G01N33/0039 ,  G01N27/123 ,  G01N33/0037 ,  Y02A50/245 ,  Y02A50/247 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/177692 ,  Y10T436/178459 ,  Y10T436/179228 ,  Y10T436/206664 ,  Y10T436/25875

摘要： An analytical system is provided for determining nitrogen monoxide, nitrogen dioxide and ozone concentrations in air samples. An ultraviolet light source is used to alter the equilibrium between nitrogen dioxide and oxygen on the one hand and nitrogen monoxide and ozone on the other. Dynamic measurement of ozone concentration with time whilst ultraviolet irradiation is pulsed enables each gas concentration to be calculated without requiring input gases to be scrubbed. An apparatus is further provided to provide a controlled flow of gas to a sensor attached to a high altitude balloon whilst sheltering it from the elements and allowing for affects of temperature, said apparatus comprising a shield and a gas conducting means which uses the venturi effect to control air flow or has a hole to allow water to drain without affecting air flow past the sensor.

摘要翻译： 提供了一种分析系统，用于确定空气样品中的一氧化氮，二氧化氮和臭氧浓度。 使用紫外光源一方面改变二氧化氮和氧气之间的平衡，另一方面改变一氧化氮和臭氧。 臭氧浓度随时间的动态测量，同时紫外线照射被脉冲化，可以计算每种气体浓度，而不需要输入气体进行擦洗。 还提供一种装置，用于向连接到高空气球的传感器提供受控的气体流，同时将其与元件遮蔽并允许温度的影响，所述装置包括屏蔽件和导气装置，其使用文丘里效应 控制空气流动或具有一个孔以允许水排出而不影响通过传感器的空气流。

公开(公告)号：US06306609B1

公开(公告)日：2001-10-23

申请号：US09274718

申请日：1999-03-22

申请人： Ching-San Lai

发明人： Ching-San Lai

IPC分类号： G01N3353

CPC分类号： G01N1/4005 ,  G01N33/0037 ,  G01N33/487 ,  G01N2001/4016 ,  Y02A50/245 ,  Y10S210/903 ,  Y10T436/177692 ,  Y10T436/179228

摘要： In accordance with the present invention, there are provided articles for use in non-invasive measurements of nitric oxide levels in a variety of fluid media, e.g., in mammalian body fluids. Articles according to the present invention comprise a nitric oxide trapping agent contained within a vessel, wherein the vessel comprises a semi-permeable membrane. Nitric oxide diffuses through the semi-permeable membrane and is trapped therein for subsequent quantitative analysis. Articles of the present invention are particularly useful in selectively detecting nitric oxide in the presence of other NOx species.

摘要翻译： 根据本发明，提供了用于非侵入性测量各种流体介质（例如哺乳动物体液）中一氧化氮水平的制品。 根据本发明的制品包含容纳在容器内的一氧化氮捕集剂，其中容器包括半透膜。 一氧化氮通过半透膜扩散并被捕获在其中用于随后的定量分析。 本发明的制品特别适用于在存在其它NOx种类的情况下选择性地检测一氧化氮。

公开(公告)号：US06201134B1

公开(公告)日：2001-03-13

申请号：US09446899

申请日：2000-04-03

申请人： Tetsuo Nagano ,  Hirotatsu Kojima

发明人： Tetsuo Nagano ,  Hirotatsu Kojima

IPC分类号： C07D31188

CPC分类号： G01N31/223 ,  C07D311/82 ,  C09B11/24 ,  Y10T436/177692

摘要： A compound represented by the following general formula: wherein R1 and R2 represent amino groups present at adjacent positions each other on the phenyl ring; R3, R4, R5 and R6 independently represent a C1-6 alkyl group; R7, R8, R9 and R10 independently represent a hydrogen atom, a C1-6 alkyl group, an allyl group, or a halogen atom; R11 represents a hydrogen atom or a C1-18 alkyl group; and X− represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.

摘要翻译： 由以下通式表示的化合物：其中R 1和R 2表示在苯环上相邻位置上存在的氨基; R3，R4，R5和R6独立地表示C1-6烷基; R 7，R 8，R 9和R 10独立地表示氢原子，C 1-6烷基，烯丙基或卤素原子; R11表示氢原子或C1-18烷基; 和X-表示阴离子，和含有所述化合物的一氧化氮测定剂。化合物与一氧化氮有效反应，得到通过长波长激发光照射而发出强荧光的荧光化合物。 该荧光化合物的特征在于，所述化合物在几乎不受细胞自发荧光影响的荧光波长范围内是可检测的，其荧光强度在酸性条件下不衰减。

公开(公告)号：US6087181A

公开(公告)日：2000-07-11

申请号：US39991

申请日：1998-03-16

申请人： Pejun Cong

发明人： Pejun Cong

IPC分类号： B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  G01N21/17 ,  G01N21/65 ,  G01N21/41 ,  G01B9/02 ,  G01N21/45

CPC分类号： G01N21/171 ,  B01J19/0046 ,  B01J2219/00707 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/177692 ,  Y10T436/20 ,  Y10T436/204998 ,  Y10T436/205831 ,  Y10T436/21 ,  Y10T436/214 ,  Y10T436/216 ,  Y10T436/25875

摘要： The present invention discloses a method for improving the speed and sensitivity of optical spectroscopic techniques for remote detection of trace chemical species in a carrier gas. The disclosed method can be applied to any optical spectroscopic detection technique whose sensitivity decreases as the total pressure of the sample decreases. The method employs an inert and non-absorbing buffer gas to supplement the pressure exerted by the carrier gas. This ensures that the total pressure of the sample, and hence sensitivity of the detection technique, remains high. The method is especially useful when measuring concentration of chemical species produced at small rates, and therefore should prove useful for rapid serial screening of combinatorial libraries of compounds.

摘要翻译： 本发明公开了一种提高载体气体中痕量化学物质的远程检测光谱技术的速度和灵敏度的方法。 所公开的方法可以应用于任何光谱检测技术，其灵敏度随着样品总压降低而降低。 该方法采用惰性和非吸收缓冲气体来补充由载气施加的压力。 这确保了样品的总压力以及因此检测技术的灵敏度仍然很高。 当测量以较小的速率产生的化学物质的浓度时，该方法特别有用，因此应证明可用于化合物组合文库的快速连续筛选。

公开(公告)号：US5994144A

公开(公告)日：1999-11-30

申请号：US178357

申请日：1994-01-04

申请人： Eiichi Nakajima ,  Yasuo Udoh ,  Tsutomu Iikawa ,  Toshisuke Kitakohji ,  Teruo Motoyoshi ,  Takashi Furusawa ,  Shiori Yamazaki ,  Masao Nakayama ,  Michiko Satoh ,  Shigeru Fukushima ,  Mayumi Itabashi

发明人： Eiichi Nakajima ,  Yasuo Udoh ,  Tsutomu Iikawa ,  Toshisuke Kitakohji ,  Teruo Motoyoshi ,  Takashi Furusawa ,  Shiori Yamazaki ,  Masao Nakayama ,  Michiko Satoh ,  Shigeru Fukushima ,  Mayumi Itabashi

IPC分类号： G01N1/22 ,  G01N1/34 ,  G01N1/40 ,  G01N17/04 ,  G01N33/00

CPC分类号： G01N1/405 ,  G01N1/2273 ,  G01N1/2214 ,  Y10T436/177692 ,  Y10T436/186 ,  Y10T436/204998 ,  Y10T436/255

摘要： When adsorbed gas is analyzed after metal, ceramics or metallic salt has been left in an environmental atmosphere for a predetermined period of time, an average concentration of specific gas over a long period of time can be accurately measured with an inexpensive small apparatus. Especially, porous metal or ceramics (transition metal oxide) are excellent in selective adsorption properties for NO.sub.x, porous ceramics (rare earth element oxide) are excellent in selective adsorption properties for CO.sub.2, and a specific chloride such as copper chloride and silver chloride is excellent in selective adsorption properties for SO.sub.2. A test kit accommodating such test pieces in a case, a protective case for the test kit to put the test kit into practical use, an umbrella and a forced air blowing unit are also disclosed.

摘要翻译： 当在金属之后分析吸附气体时，陶瓷或金属盐已经在环境气氛中保持预定的时间，可以用便宜的小型设备来精确地测量长时间的比气体的平均浓度。 特别是，多孔金属或陶瓷（过渡金属氧化物）对于NOx的选择性吸附性优异，多孔质陶瓷（稀土元素氧化物）对于CO 2的选择性吸附性优异，氯化铜和氯化银等特定氯化物优异 在SO2的选择吸附性能。 还公开了一种在壳体中容纳这种测试件的测试组件，用于将测试组件投入实际使用的测试套件的保护壳，伞和强制吹风单元。

公开(公告)号：US5922610A

公开(公告)日：1999-07-13

申请号：US578653

申请日：1996-01-05

申请人： Kjell Alving ,  Edward Weitzberg ,  Jan Lundberg

发明人： Kjell Alving ,  Edward Weitzberg ,  Jan Lundberg

IPC分类号： A61B5/08 ,  A61B5/083 ,  G01N29/02 ,  G01N29/22 ,  G01N33/00 ,  G01N33/497

CPC分类号： G01N33/497 ,  G01N29/02 ,  G01N29/222 ,  G01N33/0026 ,  G01N33/0037 ,  G01N2291/0215 ,  G01N2291/02845 ,  G01N2291/0422 ,  G01N2291/0427 ,  Y10T436/17 ,  Y10T436/177692 ,  Y10T436/25875

摘要： The present invention is drawn to a system to be used for measuring NO levels in exhaled breathing air. The system comprises: (i) a face mask that tightly covers the nose and/or mouth of the individual that the mask is intended to be used on; (ii) an inlet unit for inhaled breathing air, (iii) an outlet unit for exhaled breathing air, (iv) a non-rebreathing valve through which inhaled and exhaled breathing air, respectively, passes, and (v) a measuring unit for NO connected to the outlet unit. The present invention furthers encompasses a method for the diagnosis in mammals of inflammatory conditions in the airways. The characteristic feature is that nitric oxide NO is measured in exhaled breathing air and a found abnormal level is taken as an indication of an inflammatory condition in the airways.

摘要翻译： PCT No.PCT / SE94 / 00659 Sec。 371日期1996年1月5日 102（e）日期1996年1月5日PCT提交1994年7月4日PCT公布。 WO95 / 02181 PCT出版物 日期1995年1月19日本发明涉及用于测量呼出呼吸空气中的NO水平的系统。 所述系统包括：（i）紧密地覆盖所述个人的鼻子和/或口部的口罩，所述口罩旨在用于所述面罩; （ii）用于吸入呼吸空气的入口单元，（iii）用于呼出呼吸空气的出口单元，（iv）分别吸入和呼出的呼吸空气通过的非再呼吸阀，以及（v）用于 NO连接到出口单元。 本发明进一步包括用于在哺乳动物中诊断气道中的炎性病症的方法。 其特征是在呼出呼吸空气中测量一氧化氮NO，发现异常水平作为气道炎症状态的指标。

公开(公告)号：US5869344A

公开(公告)日：1999-02-09

申请号：US896487

申请日：1997-07-18

申请人： Robert Steven Timothy Linforth ,  Andrew John Taylor

发明人： Robert Steven Timothy Linforth ,  Andrew John Taylor

IPC分类号： G01N33/00 ,  G01N33/02 ,  G01N33/497 ,  H01J49/04 ,  G01N27/00 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/0422 ,  G01N33/0011 ,  H01J49/24 ,  G01N33/02 ,  G01N33/497 ,  Y10T436/17 ,  Y10T436/177692 ,  Y10T436/18 ,  Y10T436/182 ,  Y10T436/19 ,  Y10T436/20 ,  Y10T436/24 ,  Y10T436/25625 ,  Y10T436/25875

摘要： The invention comprises a novel sample introduction system which incorporates a venturi pump to convey a sample gas to an analytical instrument at atmospheric pressure. An APCI, ICP or MIP mass spectrometer is preferred as the analytical instrument. Using such an inlet with an APCI mass spectrometer, the real-time analysis of trace materials present in breath is facilitated, enabling, for example, the release of compounds responsible for aroma and taste to be analysed during eating and drinking. The invention can also be used for headspace analysis and for monitoring the release of fragrances from skin or clothing.

摘要翻译： 本发明包括一种新颖的样品引入系统，其包括文丘里泵以在大气压力下将样品气体输送到分析仪器。 作为分析仪器，优选APCI，ICP或MIP质谱仪。 使用这种入口与APCI质谱仪，促进呼吸中存在的痕量物质的实时分析，使得例如在饮食过程中释放负责芳香和味道的化合物进行分析。 本发明还可以用于顶空分析和用于监测香料从皮肤或衣服的释放。