公开(公告)号：US08389959B2

公开(公告)日：2013-03-05

申请号：US13147147

申请日：2009-11-30

Applicant: Satoshi Takahashi ,  Tsuyoshi Sonehara ,  Tomoyuki Sakai ,  Takanobu Haga ,  Hirokazu Kato ,  Nobutaka Kumazaki ,  Takuya Matsui

Inventor： Satoshi Takahashi ,  Tsuyoshi Sonehara ,  Tomoyuki Sakai ,  Takanobu Haga ,  Hirokazu Kato ,  Nobutaka Kumazaki ,  Takuya Matsui

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01J3/10 ,  G01J3/14 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/6452

Abstract: The present invention has an object to provide a method for efficiently detecting an image with a smaller number of pixels.The invention relates to fluorescence analysis which uses a substrate having a plurality of regions for being capable of immobilizing biologically-related molecules in positions of lattice points of a lattice structure, and which causes the fluorescence from a certain lattice point to be wavelength-dispersed in a direction other than the direction toward the adjacent closest lattice point. According to an embodiment, for example, the number of pixels of a two-dimensional sensor required for fluorescence analysis of the regions with the biologically-related molecules immobilized can be set to several hundred times to fifty times smaller than that in the conventional case without degrading the measurement accuracy. This can achieve the improvement of throughput, reduction in price, and/or improvement of the operability of an analyzing device.

Abstract translation: 本发明的目的是提供一种用于有效检测具有较少像素数的图像的方法。 本发明涉及使用具有多个区域的基板的荧光分析，其能够将生物相关分子固定在格子结构的格点的位置，并且使得来自特定格子点的荧光波长分散在 除了朝向相邻最近格子点的方向之外的方向。 根据一个实施例，例如，具有生物相关分子固定的区域的荧光分析所需的二维传感器的像素数量可以设定为比常规情况下少几百次到五十次，而没有 降低测量精度。 这可以实现分析装置的吞吐量的提高，价格的降低和/或改善可操作性。

公开(公告)号：US20120262713A1

公开(公告)日：2012-10-18

申请号：US13518797

申请日：2010-12-13

Applicant: Stefan Florek ,  Michael Okruss ,  Helmut Becker-Ross

Inventor： Stefan Florek ,  Michael Okruss ,  Helmut Becker-Ross

IPC: G01J3/42

CPC classification number: G01J3/1809 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0235 ,  G01J3/14 ,  G01J3/2803 ,  G01J2003/1828

Abstract: A spectrometer assembly (10), comprising an Echelle grating (18; 46) for dispersing radiation entering the spectrometer assembly (10) in a main dispersion direction, and a dispersion assembly (16; 40) for dispersing a parallel radiation bundle generated from the radiation entering the spectrometer assembly in a lateral dispersion direction, is characterized in that the dispersion assembly (16; 40) is reflective, and the dispersion assembly (16; 40) is arranged relative to the Echelle grating (18; 46) in such a way that the parallel radiation bundle is reflected in the direction of the Echelle grating. The Echelle grating (18; 46) may be arranged in such a way that the dispersed radiation is reflected back to the dispersion assembly (16; 40).

Abstract translation: 一种光谱仪组件（10），包括用于分散在主分散方向上进入光谱仪组件（10）的辐射的梯形光栅（18; 46）和用于分散从所述分散体组件（10; 40）产生的平行辐射束 辐射进入光谱仪组件的横向分散方向，其特征在于分散体组件（16; 40）是反射性的，分散体组件（16; 40）相对于Echelle光栅（18; 46） 平行辐射束在Echelle光栅的方向上反射的方式。 可以将梯形光栅（18; 46）布置成使得分散的辐射被反射回到分散体组件（16; 40）。

公开(公告)号：US08264687B2

公开(公告)日：2012-09-11

申请号：US13102551

申请日：2011-05-06

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US20120218548A1

公开(公告)日：2012-08-30

申请号：US13465911

申请日：2012-05-07

Applicant: Andrew Bodkin

Inventor： Andrew Bodkin

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0294 ,  G01J3/14 ,  G01J3/2803 ,  G01J3/2823 ,  G01J3/36

Abstract: Hyperspectral imaging system and methods that may be used for imaging objects in three-dimensions are disclosed. A cylindrical lens array and/or a slit array may be used to re-image and divide a field of view into multiple channels. The multiple channels are dispersed into multiple spectral signatures and observed on a two-dimensional focal plane array in real time. The entire hyperspectral data cube is collected simultaneously.

Abstract translation: 公开了可以用于三维成像对象的高光谱成像系统和方法。 可以使用柱面透镜阵列和/或狭缝阵列来将视场重新图像分割成多个通道。 将多个通道分散到多个光谱特征中，并在二维焦平面阵列上实时观察。 整个高光谱数据立方体被同时收集。

公开(公告)号：US08189191B2

公开(公告)日：2012-05-29

申请号：US12239628

申请日：2008-09-26

Applicant: Michael R. Webb ,  Christopher Lafratta ,  David R. Walt

Inventor： Michael R. Webb ,  Christopher Lafratta ,  David R. Walt

IPC: G01J3/28

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/0264 ,  G01J3/14 ,  G01J3/32 ,  G02B21/06 ,  G02B21/367

Abstract: Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.

Abstract translation: 这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的空间分散的光的一部分作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。

公开(公告)号：US20120081706A1

公开(公告)日：2012-04-05

申请号：US13105616

申请日：2011-05-11

Applicant: Lacy G. COOK ,  John F. SILNY

Inventor： Lacy G. COOK ,  John F. SILNY

IPC: G01J3/28 ,  G02B5/04

CPC classification number: G01J3/14 ,  G02B1/02 ,  G02B5/04

Abstract: A spectrometer comprises a detector array and a prism. The prism comprises a first prism element comprising a substantially crystalline crown material, and a second prism element contacting the first prism element, the second prism element comprising a substantially crystalline flint material. The spectrometer further includes optics configured to direct light at least twice through the prism. The prism is configured to disperse light received from the optics at an incident angle therethrough into constituent spectra in visible and infrared wavelength bands that are dispersed from the prism at angles offset from the incident angle. The constituent spectra are directed onto the detector array with approximately equal dispersion across the visible and infrared wavelength bands. Among other things, desirable material selections for the first and second prism elements are also disclosed.

Abstract translation: 光谱仪包括检测器阵列和棱镜。 棱镜包括包括基本上结晶的冠状材料的第一棱镜元件和与第一棱镜元件接触的第二棱镜元件，第二棱镜元件包括基本上结晶的火石材料。 光谱仪还包括被配置为将光引导至少两次穿过棱镜的光学器件。 棱镜被构造成以入射角将从光学器件接收的光分散成从可见光和红外波长带组成的光谱，其以从入射角度偏移的角度从棱镜分散出来。 组成光谱以可见光和红外波段的近似相等的色散指向检测器阵列。 此外，还公开了用于第一和第二棱镜元件的期望的材料选择。

公开(公告)号：US20120081705A1

公开(公告)日：2012-04-05

申请号：US12896620

申请日：2010-10-01

Applicant: Lacy G. COOK ,  John F. SILNY

Inventor： Lacy G. COOK ,  John F. SILNY

IPC: G01J3/28 ,  G02B5/04

CPC classification number: G02B27/1006 ,  G01J3/0291 ,  G01J3/14 ,  G01J3/2823 ,  G02B17/082 ,  G02B27/126

Abstract: A spectrometer comprises a detector array and a prism. The prism comprises a first prism element comprising a substantially crystalline crown material, and a second prism element contacting the first prism element, the second prism element comprising a substantially crystalline flint material. The spectrometer further includes optics configured to direct light at least twice through the prism. The prism is configured to disperse light received from the optics at an incident angle therethrough into constituent spectra in visible and infrared wavelength bands that are dispersed from the prism at angles offset from the incident angle. The constituent spectra are directed onto the detector array with approximately equal dispersion across the visible and infrared wavelength bands. Among other things, desirable material selections for the first and second prism elements are also disclosed.

公开(公告)号：US08098374B2

公开(公告)日：2012-01-17

申请号：US12444244

申请日：2007-10-02

Applicant: Ralf Wolleschensky ,  Hans-Juergen Dobschal ,  Reinhard Steiner

Inventor： Ralf Wolleschensky ,  Hans-Juergen Dobschal ,  Reinhard Steiner

IPC: G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/14 ,  G01J3/26 ,  G01J3/2803

Abstract: The invention is directed to a highly sensitive spectrum analysis unit with a diffraction grating, wherein a parallel light bundle having a wavelength range impinges on a diffraction grating which splits the different wavelengths into spectra by diffraction in first directions, and wavelength partial ranges of the spectrally split light bundle can be focused on a detector row by means of camera optics, and evaluation electronics are connected to the detector row and acquire the generated spectrum as information and display it. The invention is characterized in that the light bundle passes a first optical element, and then wavelength partial ranges of a spectrally split light bundle impinge on respective partial regions of a diffraction grating, the diffraction grating having the same grating constant across all partial regions and a changing profile shape, the profile shapes generating different blaze wavelengths that lie in the respective wavelength partial ranges.

Abstract translation: 本发明涉及一种具有衍射光栅的高灵敏度光谱分析单元，其中具有波长范围的平行光束照射在衍射光栅上，衍射光栅通过在第一方向上的衍射将不同波长分裂成光谱，并且光谱的波长部分范围 分光束可以通过相机光学器件聚焦在检测器行上，并且评估电子器件连接到检测器行并且获取所生成的光谱作为信息并显示它。 本发明的特征在于，光束通过第一光学元件，然后将光谱分裂的光束的部分范围波动在衍射光栅的各个部分区域上，衍射光栅在所有部分区域具有相同的光栅常数，并且 改变轮廓形状，产生位于相应波长部分范围内的不同火焰波长的轮廓形状。

公开(公告)号：US20110282167A1

公开(公告)日：2011-11-17

申请号：US13145927

申请日：2010-01-23

Applicant: Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

Inventor： Trent Ridder ,  Ben Ver Steeg ,  Mike Mills ,  Bentley Laaksonen

IPC: A61B5/1455

CPC classification number: A61B5/4845 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6826 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0291 ,  G01J3/14 ,  G01J2003/1286 ,  G01N21/274 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/129

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal- to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination/modulation subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Abstract translation: 一种用于通过定量红外光谱法非侵入性地确定人体组织属性的装置和方法，其临床相关的精度和准确性水平。 该系统包括针对组织谱的复杂性，高信噪比和光度精度要求进行优化的子系统，组织抽样误差，校准维护问题和校准传递问题。 子系统包括照明/调制子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。

公开(公告)号：US08009278B2

公开(公告)日：2011-08-30

申请号：US12648714

申请日：2009-12-29

Applicant: Carl W. Dirk

Inventor： Carl W. Dirk

IPC: G01N21/00

CPC classification number: G01J3/51 ,  G01J3/12 ,  G01J3/14 ,  G01J3/28 ,  G01J3/524 ,  G01J2003/1282 ,  G02B27/0012 ,  Y10T29/49

Abstract: Computer program products comprising tangible computer-readable media having instructions that are executable by a computer to generate a customized spectral profile, which can be used to generate a corresponding filter. The instructions can comprise: generating a trial source spectrum; determining an uncorrected lamp source spectrum; calculating one or more optical indices using the trial source spectrum or the uncorrected lamp source spectrum; and optimizing one or more of the optical indices by varying the trial source spectrum to generate the customized spectral profile.

Abstract translation: 计算机程序产品包括具有指令的有形计算机可读介质，所述指令可由计算机执行以产生定制的谱图，其可用于生成相应的滤波器。 该指令可以包括：产生试验源频谱; 确定未校正的灯源光谱; 使用试验源光谱或未校正的灯源光谱计算一个或多个光学折射率; 以及通过改变试验源频谱来优化一个或多个光学指数以产生定制的光谱分布。