公开(公告)号：US20160227830A1

公开(公告)日：2016-08-11

申请号：US15134252

申请日：2016-04-20

申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI ,  PEOPLE FOR THE ETHICAL TREATMENT OF ANIMALS

发明人： Nicholas J. GENOVESE ,  R. Michael ROBERTS ,  Bhanu Prakash V.L. TELUGU

IPC分类号： A23L1/31 ,  C12N5/077 ,  C12N15/85

CPC分类号： C12N5/0658 ,  A23L13/00 ,  A23V2002/00 ,  A61K35/28 ,  A61K35/545 ,  C12N5/10 ,  C12N2501/392 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/60 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/72 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45

摘要： The present disclosure relates to methods for enhancing cultured meat production, such as livestock-autonomous meat production. In certain aspects, the meat is any metazoan tissue or cell-derived comestible product intended for use as a comestible food or nutritional component by humans, companion animals, domesticated or captive animals whose carcasses are intended for comestible use, service animals, conserved animal species, animals used for experimental purposes, or cell cultures.

公开(公告)号：US20160151423A1

公开(公告)日：2016-06-02

申请号：US14659568

申请日：2015-03-16

申请人： CITY OF HOPE

发明人： Sanjay AWASTHI ,  Sushma YADAV ,  Ismail AL ABDULLAH ,  Fouad KANDEEL ,  Brian MCFADDEN ,  Indu NAIR ,  Sharad S. SINGHAL

IPC分类号： A61K35/39 ,  C12N9/10 ,  A61K38/45 ,  A61K38/46 ,  C12N5/071 ,  C12N15/86

CPC分类号： A61K35/39 ,  A61K38/45 ,  C12N5/0676 ,  C12N9/1088 ,  C12N2501/72 ,  C12Y205/01018

摘要： The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase β-cell viability.

摘要翻译： 本公开提供了通过递送RLIP76多肽或GSTA4多肽或其组合来增加胰岛细胞活力的新方法; 或RLIP76多核苷酸或GSTA4多核苷酸，或其组合。 本公开还提供了通过递送RLIP76多肽或GSTA4多肽或其组合来治疗受试者例如1型糖尿病的疾病或病症的新方法; 或RLIP76多核苷酸或GSTA4多核苷酸或其组合，将胰岛移植到受试者中以治疗疾病或病症。 包含RLIP76多肽或GSTA4多肽的试剂盒和组合物，或其组合; 或RLIP76多核苷酸或GSTA4多核苷酸或其组合，以提高细胞活力。

公开(公告)号：US20160010059A1

公开(公告)日：2016-01-14

申请号：US14773114

申请日：2014-03-06

申请人： Fernando UGARTE

发明人： Fernando Ugarte

IPC分类号： C12N5/0789

CPC分类号： C12N5/0647 ,  C12N2501/72

摘要： The invention provides compositions and methods that may be used to prevent and/or decelerate differentiation of stem cells. The invention may be used to maintain and expand a population of stem cells from a human subject, thereby providing a substantially greater population of stem cells for clinical and therapeutic treatments for various diseases and disorders.

摘要翻译： 本发明提供可用于预防和/或减缓干细胞分化的组合物和方法。 本发明可用于维持和扩大来自人类受试者的干细胞群体，从而提供大量更多的干细胞群，用于各种疾病和病症的临床和治疗性治疗。

公开(公告)号：US09187728B2

公开(公告)日：2015-11-17

申请号：US13704424

申请日：2011-06-13

申请人： Taito Nishino ,  Atsushi Iwama

发明人： Taito Nishino ,  Atsushi Iwama

IPC分类号： A61K38/00 ,  C12N5/00 ,  C12N5/0789 ,  A61K31/122 ,  A61K31/352

CPC分类号： C12N5/0647 ,  A61K31/122 ,  A61K31/352 ,  C12N2500/62 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/26 ,  C12N2501/72 ,  C12N2501/727 ,  C12N2501/999

摘要： An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided.A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R6 are as defined in the description).

摘要翻译： 提供了用作造血干细胞和/或造血祖细胞的扩增剂，其用作各种造血疾病的治疗，并且可用于提高基因转移到造血干细胞中用于基因治疗的效率。 一种产生造血干细胞和/或造血祖细胞的方法，其包括通过在下列通式（I）表示的化合物存在下体外培养造血干细胞来扩大造血干细胞，其中所述化合物的互变异构体或药学上可接受的盐 化合物或其溶剂合物（其中R1至R6如说明书中所定义）。

公开(公告)号：US20130011380A1

公开(公告)日：2013-01-10

申请号：US13511989

申请日：2010-12-17

申请人： Helen M. Blau ,  Nidhi Bhutani ,  Jennifer Brady ,  Mara Damian

发明人： Helen M. Blau ,  Nidhi Bhutani ,  Jennifer Brady ,  Mara Damian

IPC分类号： A61K38/50 ,  C12N15/87 ,  C12N5/09 ,  A61K48/00 ,  C12Q1/68 ,  G01N27/62 ,  G01N33/53 ,  C12N5/071 ,  C12N5/0735

CPC分类号： C12N5/16 ,  C12N5/0696 ,  C12N2501/72

摘要： Methods, compositions and kits for modulating demethylation in a mammalian cell are provided. Also provided are methods, compositions and kits for screening candidate agents for activity in modulating genomic DNA demethylation in mammalian cells. These methods, compositions and kits find use in producing induced pluripotent stem cells (iPS) and somatic cells in vitro and for treating human disorders including cancer and disorders arising from defects in genomic imprinting.

摘要翻译： 提供了用于调节哺乳动物细胞中去甲基化的方法，组合物和试剂盒。 还提供了用于筛选哺乳动物细胞中调节基因组DNA去甲基化活性的候选试剂的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于在体外产生诱导性多能干细胞（iPS）和体细胞，并用于治疗人类疾病，包括由基因组印记缺陷引起的癌症和疾病。