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    SMC1A ANTIBODIES AND USES THEREOF
    2.
    发明公开
    SMC1A ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：US20230340089A1

    公开(公告)日：2023-10-26

    申请号：US17998795

    申请日：2021-05-14

    申请人： CITY OF HOPE

    发明人： Sushma YADAV ,  Arthur RIGGS ,  David HORNE ,  John C. WILLIAMS

    IPC分类号： C07K16/18 ,  G01N33/574

    CPC分类号： C07K16/18 ,  G01N33/574 ,  C07K2317/31 ,  C07K2317/565

    摘要： Provided herein are, inter alia, antibodies capable of binding Structural Maintenance of Chromosome-1 (SMC1). The antibodies provided herein include novel light chain and heavy chain sequences and bind SMC1 (e.g., SMC1A or SMC1B) with high efficiency and specificity. The SMC1 antibodies provided herein including embodiments thereof may be used for diagnostic and therapeutic purposes, for example, as humanized SMC1 antibodies, antibody drug conjugates or they may form part of bispecific antibodies or chimeric antigen receptors.

    METHODS, COMPOSITIONS, AND KITS FOR IMPROVING PANCREATIC BETA CELL VIABILITY AND TREATING DISEASES OR CONDITIONS RELATED TO BETA CELL DESTRUCTION
    4.
    发明申请
    METHODS, COMPOSITIONS, AND KITS FOR IMPROVING PANCREATIC BETA CELL VIABILITY AND TREATING DISEASES OR CONDITIONS RELATED TO BETA CELL DESTRUCTION 有权
    用于改善胰腺癌细胞毒性的方法，组合物和用具以及与细胞破坏相关的治疗疾病或病症

    公开(公告)号：US20160151423A1

    公开(公告)日：2016-06-02

    申请号：US14659568

    申请日：2015-03-16

    申请人： CITY OF HOPE

    发明人： Sanjay AWASTHI ,  Sushma YADAV ,  Ismail AL ABDULLAH ,  Fouad KANDEEL ,  Brian MCFADDEN ,  Indu NAIR ,  Sharad S. SINGHAL

    IPC分类号： A61K35/39 ,  C12N9/10 ,  A61K38/45 ,  A61K38/46 ,  C12N5/071 ,  C12N15/86

    CPC分类号： A61K35/39 ,  A61K38/45 ,  C12N5/0676 ,  C12N9/1088 ,  C12N2501/72 ,  C12Y205/01018

    摘要： The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase β-cell viability.

    摘要翻译： 本公开提供了通过递送RLIP76多肽或GSTA4多肽或其组合来增加胰岛细胞活力的新方法; 或RLIP76多核苷酸或GSTA4多核苷酸，或其组合。 本公开还提供了通过递送RLIP76多肽或GSTA4多肽或其组合来治疗受试者例如1型糖尿病的疾病或病症的新方法; 或RLIP76多核苷酸或GSTA4多核苷酸或其组合，将胰岛移植到受试者中以治疗疾病或病症。 包含RLIP76多肽或GSTA4多肽的试剂盒和组合物，或其组合; 或RLIP76多核苷酸或GSTA4多核苷酸或其组合，以提高细胞活力。