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公开(公告)号：US20170096187A1
公开(公告)日：2017-04-06
申请号：US15384012
申请日：2016-12-19
申请人： David Rosen
发明人： David Rosen
CPC分类号： B62M9/127 , B62J99/00 , B62J2099/0046 , B62K23/02 , B62K23/06 , B62M25/04 , B62M25/045 , B62M25/08 , F16L3/1218 , Y10T74/20462
摘要： The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.
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公开(公告)号：US09034257B2
公开(公告)日：2015-05-19
申请号：US12606869
申请日：2009-10-27
申请人： Todd Covey , Adam Palazzo , Norman Purvis , James Cordiero , David Rosen
发明人： Todd Covey , Adam Palazzo , Norman Purvis , James Cordiero , David Rosen
CPC分类号： G01N35/00722 , G01N33/5008 , G01N33/53 , G01N35/00732 , G01N35/0099 , G01N35/028 , G01N35/1095 , G01N2035/00435 , G01N2035/00752 , G01N2035/0091
摘要： The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.
摘要翻译： 本发明提供用于使用流式细胞仪自动处理生物样品和分析的系统，组合物，试剂盒和方法。
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公开(公告)号：US08426558B2
公开(公告)日：2013-04-23
申请号：US12968532
申请日：2010-12-15
IPC分类号： C07K14/00
摘要： The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.
摘要翻译： 本发明是刺激骨组织和软骨等硬组织形成的肽化合物。 本发明还涉及使用肽治疗硬组织如骨和软骨中的缺陷的方法。 本发明的方法可用于治疗或预防由类风湿性关节炎或骨关节炎引起的骨骼和软骨中的缺陷，其涉及在缺损中或周围新骨或软骨的再生。
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34.发明申请ASSIST ENGINE FOR TRANSMIT AND RECEIVE FUNCTIONS IN A MODULAR WIRELESS NETWORK ACCESS DEVICE 有权用于模块化无线网络接入设备中发射和接收功能的辅助发动机公开(公告)号：US20130089031A1
公开(公告)日：2013-04-11
申请号：US13647054
申请日：2012-10-08
申请人： Drew Bertagna , David Rosen
发明人： Drew Bertagna , David Rosen
IPC分类号： H04W88/08
CPC分类号： H04W28/0278 , H01Q3/242 , H04L49/9057 , H04W84/12 , H04W88/08 , H04W88/10
摘要： A wireless network access device comprising a radio interface with a serial communication line, a switch, and M serial connections to M connectors for connecting up to M corresponding detachable radio modules. The radio interface forms up to M individually addressable radio communications paths. Each radio module includes a radio configured to communicate with client devices in a coverage area and a radio processor configured to manage at least one radio receiving buffer. The radio receiving buffers store receiver buffer identifiers to corresponding received data space. A processor manages communication between the client devices that communicate with the radio modules and a data network via the radio interface and a network interface when N
摘要翻译： 一种无线网络接入装置，包括具有串行通信线路的无线电接口，开关和至M个连接器的M个串行连接器，用于连接多达M个相应的可拆卸无线电模块。 无线电接口形成多达M个可单独寻址的无线电通信路径。 每个无线电模块包括被配置为与覆盖区域中的客户端设备通信的无线电设备和被配置为管理至少一个无线电接收缓冲器的无线电处理器。 无线电接收缓冲器将接收器缓冲器标识符存储到对应的接收数据空间。 当N个无线电模块连接到无线电接口时，处理器管理通过无线电接口与无线电模块通信的客户端设备和数据网络之间的通信以及网络接口。 辅助引擎在处理器和交换机之间的串行连接中连接以管理对无线电模块的接收缓冲器标识符的分配。
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公开(公告)号：US20100240542A1
公开(公告)日：2010-09-23
申请号：US12730170
申请日：2010-03-23
申请人： David Soper , David Rosen , Todd Covey , Ying-Wen Huang , Wendy Fantl , Ralph Lin
发明人： David Soper , David Rosen , Todd Covey , Ying-Wen Huang , Wendy Fantl , Ralph Lin
CPC分类号： G01N33/6842 , G01N33/5011 , G01N33/5041 , G01N33/5094 , G01N33/6845 , G01N33/80 , G01N2440/14 , G01N2510/00
摘要： As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.
摘要翻译： 如本文所公开的，本发明提供用于诊断，预后，药物发现，药物开发和患者分层的试剂盒和组合物。 试剂盒可以包含用于细胞表面标记的多个结合元件，以及用于状态特异性细胞内标记物的多个结合元件。 试剂盒还可以包含针对特定细胞功能或信号传导途径的多个调节剂。 试剂盒还可以包括固定剂，渗透剂，缓冲液，容器，说明书和用于数据分析/汇编的软件。
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公开(公告)号：US07638486B2
公开(公告)日：2009-12-29
申请号：US11457091
申请日：2006-07-12
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprising two proteins is administered to enhance biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译： 公开了促进生物过程以形成或再生新的硬组织如骨骼，软骨和/或牙科组织的制剂和方法。 施用包含两种蛋白质的制剂以增强硬组织生长和分化因子的生物活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，所述细胞内酶和信号分子在增殖，分化，成熟中起重要作用 ，和/或使硬组织形成细胞矿化。
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公开(公告)号：US07622438B1
公开(公告)日：2009-11-24
申请号：US11457088
申请日：2006-07-12
CPC分类号： A61K38/1709 , A61K38/1875 , A61K2300/00
摘要： Formulations and methods to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.
摘要翻译： 公开了促进生物过程以形成或再生新的硬组织如骨骼，软骨和/或牙科组织的制剂和方法。 该制剂增强了硬组织生长和分化因子的生物活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，其对于增殖，分化，成熟和/或矿化起重要作用 硬组织细胞。
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公开(公告)号：US20090018064A1
公开(公告)日：2009-01-15
申请号：US11926716
申请日：2007-10-29
CPC分类号： A61K38/1703 , Y02A50/473
摘要： A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.
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公开(公告)号：US20080250148A1
公开(公告)日：2008-10-09
申请号：US11696545
申请日：2007-04-04
申请人： James J. Bohannon , Andre Burgoyne , David Rosen
发明人： James J. Bohannon , Andre Burgoyne , David Rosen
IPC分类号： G06F15/16
CPC分类号： G06Q30/02 , G06Q30/0601
摘要： A method and system are herein disclosed for registering a member at a targeted web-based information management system using a reduced amount of member and system interaction to confirm and establish the member's contact information. Generally, the method may communicate permission to solicit a potential member to the information management system. In one embodiment, the member previously communicated permission to receive solicitations from other systems to another web-based information management system. The method may communicate the permission from another web-based system to the present system. The permission may include member identification and/or demographic data. The method may communicate a solicitation message from the system to the member, the solicitation message comprising at least a portion of the member identification data. The member may then communicate a confirmation message to the targeted web-based information management system, wherein the confirmation message is in reply to the solicitation message and includes the portion of the member identification data. Using the confirmation, the system may then match the portion of the member identification data from the confirmation message to the portion of the member identification data from the confirmation message.
摘要翻译： 这里公开了一种方法和系统，用于使用减少的成员和系统交互的数量在目标的基于web的信息管理系统上登记成员以确认和建立成员的联系信息。 通常，该方法可以传达许可以向潜在的成员请求信息管理系统。 在一个实施例中，该成员先前传达了许可以从其他系统接收另一个基于web的信息管理系统的请求。 该方法可以将来自另一个基于web的系统的许可传达给本系统。 许可可以包括成员标识和/或人口统计数据。 该方法可以将来自系统的请求消息传达给成员，该请求消息包括成员标识数据的至少一部分。 成员然后可以向目标基于web的信息管理系统传送确认消息，其中所述确认消息是响应于所述请求消息并且包括所述成员标识数据的所述部分。 使用该确认，系统然后可以将来自确认消息的成员标识数据的部分与来自确认消息的成员标识数据的部分相匹配。
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公开(公告)号：US20080145412A1
公开(公告)日：2008-06-19
申请号：US11735727
申请日：2007-04-16
摘要： The present invention is a method for promoting angiogenesis by administering a formulation comprising an effective amount of a peptidic compound, e.g., a peptide having the sequence TDLQERGDNDISPFSGDGQPFKD (SEQ ID NO: 30), which enhances angiogenesis through the induction of pro-angiogenic factors such as FGF2, TGFβ and fibronectin. Formulations may be administered by catheter to treat or prevent diseases and conditions which involve angiogenesis by administering an effective amount of the peptidic compound alone or in combination with one or more additional therapeutic agents.
摘要翻译： 本发明是通过施用包含有效量的肽化合物（例如具有序列TDLQERGDNDISPFSGDGQPFKD（SEQ ID NO：30）的肽）的制剂来促进血管生成的方法，其通过诱导促血管生成因子如 如FGF2，TGFbeta和纤连蛋白。 制剂可以通过导管施用以通过单独施用有效量的肽化合物或与一种或多种另外的治疗剂组合来治疗或预防涉及血管生成的疾病和病症。
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