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    ION FOCUSING
    31.
    发明申请
    ION FOCUSING 审中-公开

    公开(公告)号：US20200219711A1

    公开(公告)日：2020-07-09

    申请号：US16803023

    申请日：2020-02-27

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/10 ,  H01J49/16 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT
    34.
    发明申请
    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开

    公开(公告)号：US20190219555A1

    公开(公告)日：2019-07-18

    申请号：US16245703

    申请日：2019-01-11

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Roy Helmy ,  Yangjie Li ,  Yong Liu

    IPC: G01N33/15 ,  H01J49/00 ,  H01J49/04

    CPC classification number: G01N33/15 ,  H01J49/0027 ,  H01J49/0445

    Abstract: The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.

    ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN
    35.
    发明申请
    ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN 审中-公开

    公开(公告)号：US20190057856A1

    公开(公告)日：2019-02-21

    申请号：US15769998

    申请日：2016-10-21

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Jason Duncan ,  Joshua Wiley

    IPC: H01J49/42 ,  H01J49/00

    Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

    Ion focusing
    37.
    发明授权
    Ion focusing 有权

    公开(公告)号：US10014169B2

    公开(公告)日：2018-07-03

    申请号：US15407499

    申请日：2017-01-17

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Wen-Ping Peng

    IPC: H01J49/06 ,  H01J49/26 ,  H01J49/10 ,  H01J49/16

    CPC classification number: H01J49/067 ,  H01J49/06 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

    Abstract: The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

    Systems and methods for ejection of ions from an ion trap
    40.
    发明授权
    Systems and methods for ejection of ions from an ion trap 有权

    公开(公告)号：US09922813B2

    公开(公告)日：2018-03-20

    申请号：US15421934

    申请日：2017-02-01

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Dalton Snyder

    IPC: H01J49/42 ,  H01J49/00

    CPC classification number: H01J49/4285 ,  H01J49/0013 ,  H01J49/4225

    Abstract: The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.

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