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公开(公告)号：US11566026B2
公开(公告)日：2023-01-31
申请号：US17021581
申请日：2020-09-15
申请人： Incyte Corporation
发明人： Liangxing Wu , Bo Shen , Meizhong Xu , Wenqing Yao
IPC分类号： C07D471/04 , C07D513/04 , A61P37/04 , A61P37/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US10793565B2
公开(公告)日：2020-10-06
申请号：US16296563
申请日：2019-03-08
申请人： Incyte Corporation
发明人： Liangxing Wu , Bo Shen , Meizhong Xu , Wenqing Yao
IPC分类号： C07D471/04 , C07D513/04 , A61P37/04 , A61P37/00
摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US20190225601A1
公开(公告)日：2019-07-25
申请号：US16373150
申请日：2019-04-02
申请人： Incyte Corporation
发明人： Liangxing Wu , Jingwei Li , Chao Qi , Fenglei Zhang , Zhenwu Li , Wenyu Zhu , Zhiyong Yu , Kaijiong Xiao , Liang Lu , Song Mei , Ding-Quan Qian , Chunhong He , Yingda Ye , Meizhong Xu , Wenqing Yao
IPC分类号： C07D413/14 , A61K31/4375 , C07D487/04 , C07D513/04 , C07D498/04 , C07D413/06 , C07D471/04 , A61P37/00 , C07D413/12 , A61P37/02
摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US20190040058A1
公开(公告)日：2019-02-07
申请号：US16038924
申请日：2018-07-18
申请人： Incyte Corporation
发明人： Liangxing Wu , Leah C. Konkol , Neil Lajkiewicz , Liang Lu , Meizhong Xu , Wenqing Yao , Zhiyong Yu , Colin Zhang , Chunhong He
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
摘要： The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof, which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
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公开(公告)号：US10047086B2
公开(公告)日：2018-08-14
申请号：US15610015
申请日：2017-05-31
申请人： Incyte Corporation
发明人： Liangxing Wu , Leah C. Konkol , Neil Lajkiewicz , Liang Lu , Meizhong Xu , Wenqing Yao , Zhiyong Yu , Colin Zhang , Chunhong He
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is directed to imidazo[1,5-a]pyridine and imidazo[1,5-a]pyrazine derivatives of Formula I, or a pharmaceutically acceptable salt thereof, which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
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公开(公告)号：US20180179197A1
公开(公告)日：2018-06-28
申请号：US15850170
申请日：2017-12-21
申请人： Incyte Corporation
发明人： Liangxing Wu , Jingwei Li , Chao Qi , Fenglei Zhang , Zhenwu Li , Wenyu Zhu , Zhiyong Yu , Kaijiong Xiao , Liang Lu , Song Mei , Ding-Quan Qian , Chunhong He , Yingda Ye , Meizhong Xu , Wenqing Yao
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61P37/02
CPC分类号： C07D413/14 , A61P37/00 , A61P37/02 , C07D413/06 , C07D413/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US09670154B2
公开(公告)日：2017-06-06
申请号：US14808337
申请日：2015-07-24
申请人： Incyte Corporation
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Colin Zhang , Brian W. Metcalf , Chunhong He , Ding-Quan Qian
IPC分类号： A61K31/407 , A61K31/4439 , C07D207/06 , C07D491/107 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/52 , C07D209/62 , C07D209/70 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/38 , C07D217/06 , C07D217/26 , C07D221/20 , C07D295/185 , C07D333/34 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/20 , C07D493/10 , C07D495/04 , C07D498/20 , C07D513/10
CPC分类号： C07D207/06 , A61K31/407 , A61K31/4439 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/52 , C07D209/62 , C07D209/70 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/38 , C07D217/06 , C07D217/26 , C07D221/20 , C07D295/185 , C07D333/34 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D493/10 , C07D495/04 , C07D498/20 , C07D513/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
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公开(公告)号：US20140187530A1
公开(公告)日：2014-07-03
申请号：US14092351
申请日：2013-11-27
申请人： INCYTE CORPORATION
发明人： Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
IPC分类号： C07D221/20 , C07D401/14 , C07D495/04 , C07D405/12 , C07D487/04 , C07D405/14 , C07D417/14 , C07D401/12 , C07D471/04
CPC分类号： A61K31/496 , A61K31/40 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/4985 , A61K31/55 , A61K31/551 , C07D221/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
摘要翻译： 本发明提供了式I或式II的化合物：对映异构体，非对映异构体，前药，溶剂合物，代谢物或药学上可接受的盐，其中在本文中提供了组成变量。 式I和II的化合物是金属蛋白酶的调节剂，并且可用于治疗与金属蛋白酶活性相关的疾病，例如关节炎，癌症，心血管疾病，皮肤病，炎症和变态反应。
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公开(公告)号：US20230226062A1
公开(公告)日：2023-07-20
申请号：US17952460
申请日：2022-09-26
申请人： Incyte Corporation
发明人： Liangxing Wu , Ding-Quan Qian , Liang Lu , Neil Lajkiewicz , Leah C. Konkol , Zhenwu Li , Fenglei Zhang , Jingwei Li , Haisheng Wang , Meizhong Xu , Kaijiong Xiao , Wenqing Yao
IPC分类号： A61K31/519 , A61K31/4985 , A61K31/4725 , A61K31/4709 , A61K31/445 , A61K31/4375 , A61K31/437 , A61K31/4355 , A61K31/429 , A61K31/426 , A61K31/4196 , A61K31/4162 , A61K31/4155 , A61K31/421 , A61K31/404 , A61K31/357 , A61K31/353 , A61K31/133 , A61P31/00 , A61P35/00 , A61K31/5025 , C07D513/04 , C07D217/04 , C07D211/60 , C07D403/06 , C07D209/44 , C07C215/28 , C07D495/04 , C07D401/06 , C07D211/56 , C07D217/02 , C07D213/74 , C07D209/14 , C07D311/04 , C07D401/12 , C07D211/58 , C07D471/10 , C07C215/08 , C07D487/04 , C07D295/02 , A61P37/00 , C07D213/38
CPC分类号： A61K31/519 , A61K31/4985 , A61K31/4725 , A61K31/4709 , A61K31/445 , A61K31/4375 , A61K31/437 , A61K31/4355 , A61K31/429 , A61K31/426 , A61K31/4196 , A61K31/4162 , A61K31/4155 , A61K31/421 , A61K31/404 , A61K31/357 , A61K31/353 , A61K31/133 , A61P31/00 , A61P35/00 , A61K31/5025 , C07D513/04 , C07D217/04 , C07D211/60 , C07D403/06 , C07D209/44 , C07C215/28 , C07D495/04 , C07D401/06 , C07D211/56 , C07D217/02 , C07D213/74 , C07D209/14 , C07D311/04 , C07D401/12 , C07D211/58 , C07D471/10 , C07C215/08 , C07D487/04 , C07D295/02 , A61P37/00 , C07D213/38 , A61K2300/00
摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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公开(公告)号：US20180177784A1
公开(公告)日：2018-06-28
申请号：US15851280
申请日：2017-12-21
申请人： Incyte Corporation
发明人： Liangxing Wu , Ding-Quan Qian , Liang Lu , Neil Lajkiewicz , Leah C. Konkol , Zhenwu Li , Fenglei Zhang , Jingwei Li , Haisheng Wang , Meizhong Xu , Kaijiong Xiao , Wenqing Yao
IPC分类号： A61K31/519 , A61K31/5025 , A61K31/4985 , A61K31/4725 , A61K31/4709 , A61K31/445 , A61K31/4375 , A61K31/437 , A61K31/4355 , A61K31/429 , A61K31/426 , A61K31/4196 , A61K31/4162 , A61K31/4155 , A61K31/421 , A61K31/404 , A61K31/357 , A61K31/353 , A61K31/133 , A61P31/00 , A61P35/00
CPC分类号： A61K31/519 , A61K31/133 , A61K31/353 , A61K31/357 , A61K31/404 , A61K31/4155 , A61K31/4162 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/429 , A61K31/4355 , A61K31/437 , A61K31/4375 , A61K31/445 , A61K31/4709 , A61K31/4725 , A61K31/4985 , A61K31/5025 , A61K2300/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07C215/08 , C07C215/28 , C07D209/14 , C07D209/44 , C07D211/56 , C07D211/58 , C07D211/60 , C07D213/38 , C07D213/74 , C07D217/02 , C07D217/04 , C07D295/02 , C07D311/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D471/10 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I′), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds inhibit PD-1/PD-L1 interaction and are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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