发明申请
US20140187530A1 AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
有权
AZA螺环烷衍生物作为金属蛋白酶抑制剂
- 专利标题： AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
- 专利标题（中）： AZA螺环烷衍生物作为金属蛋白酶抑制剂
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申请号： US14092351申请日： 2013-11-27
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公开(公告)号： US20140187530A1公开(公告)日： 2014-07-03
- 发明人: Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
- 申请人： INCYTE CORPORATION
- 申请人地址： US DE Wilmington
- 专利权人： INCYTE CORPORATION
- 当前专利权人： INCYTE CORPORATION
- 当前专利权人地址： US DE Wilmington
- 主分类号： C07D221/20
- IPC分类号： C07D221/20 ; C07D401/14 ; C07D495/04 ; C07D405/12 ; C07D487/04 ; C07D405/14 ; C07D417/14 ; C07D401/12 ; C07D471/04
摘要：
The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
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