Patent search ap:("George A. Doherty") AND inv:"George A. Doherty" Page 4

31.

发明授权
Aminoalkylphosphonates and related compounds as Edg receptor agonists 失效
Title translation: 氨基烷基膦酸盐和相关化合物作为Edg受体激动剂

公开(公告)号：US07309721B2

公开(公告)日：2007-12-18

申请号：US10505257

申请日：2003-02-27

Applicant: Richard J. Budhu , George A. Doherty , Jeffrey J. Hale , Christopher L. Lynch , Sander G. Mills , William E. Neway, III

Inventor： Richard J. Budhu , George A. Doherty , Jeffrey J. Hale , Christopher L. Lynch , Sander G. Mills , William E. Neway, III

IPC: A61K31/185 , A61K31/4196 , A61K31/4192 , A61K31/417 , A61K31/41 , C07D257/04 , C07D233/84 , C07D249/04 , C07D249/12 , C07F9/02

CPC classification number: C07D257/04 , C07C229/34 , C07C309/24 , C07C311/51 , C07D233/84 , C07D249/04 , C07D249/12 , C07D257/06 , C07F9/094 , C07F9/3808 , C07F9/3826 , C07F9/3882

Abstract: The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

Abstract translation: 本发明包括化合物或式（I）：及其药学上可接受的盐和水合物。该化合物可用于治疗免疫介导的疾病和病症，例如骨髓，器官和组织移植排斥反应。包括药物组合物和使用方法。

32.

发明授权
Substituted cyclic amidine derivatives as inhibitors of cell adhesion 失效

公开(公告)号：US06482840B2

公开(公告)日：2002-11-19

申请号：US09862194

申请日：2001-05-21

Applicant: William K. Hagmann , George A. Doherty , Shrenik Shah

Inventor： William K. Hagmann , George A. Doherty , Shrenik Shah

IPC: A61K3144

CPC classification number: C07D211/72

Abstract: Compounds of Formula I are antagonists of VLA-4 and/or &agr;4&bgr;7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

33.

发明授权
Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases 有权
Title translation: 凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病

公开(公告)号：US08546399B2

公开(公告)日：2013-10-01

申请号：US12787682

申请日：2010-05-26

Applicant: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen

Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen

IPC: A61K31/407 , C07D401/12

CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。

34.

发明授权
4-substituted phenoxyphenylacetic acid derivatives 有权
Title translation: 4-取代苯氧基苯乙酸衍生物

公开(公告)号：US08492437B2

公开(公告)日：2013-07-23

申请号：US13448689

申请日：2012-04-17

Applicant: George A. Doherty , Adam Cook

Inventor： George A. Doherty , Adam Cook

IPC: C07D211/22 , C07D211/84 , C07D333/22 , C07D233/00 , C07C229/00 , A01N37/12 , A01N37/44

CPC classification number: C07C311/19 , C07C233/75 , C07C233/87 , C07C235/46 , C07C255/57 , C07C271/22 , C07C307/06 , C07C311/06 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D213/71 , C07D213/81 , C07D213/82 , C07D233/42 , C07D333/16 , Y02P20/55

Abstract: Compounds of formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

Abstract translation: 其中R1，R2，R7，R8，R9，R10和A具有本说明书中给出的含义的式（I）化合物是可用于治疗免疫疾病的DP2受体调节剂。

35.

发明授权
8-substituted benzoazepines as toll-like receptor modulators 有权
Title translation: 8-取代苯并吖庚因作为toll样受体调节剂

公开(公告)号：US08304407B2

公开(公告)日：2012-11-06

申请号：US13414579

申请日：2012-03-07

Applicant: George A. Doherty , Charles Todd Eary , Robert D. Groneberg , Zachary Jones

Inventor： George A. Doherty , Charles Todd Eary , Robert D. Groneberg , Zachary Jones

IPC: A61P37/00 , A61K31/55 , C07D223/16 , C07D403/10

CPC classification number: C07D223/16

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法用于治疗自身免疫，炎症过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

36.

发明申请
8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS 有权
Title translation: 作为类似感受体调节剂的8-取代的苯并噻唑

公开(公告)号：US20120165317A1

公开(公告)日：2012-06-28

申请号：US13414579

申请日：2012-03-07

Applicant: George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones

Inventor： George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones

IPC: A61K31/55 , A61P37/08 , A61P35/00

CPC classification number: C07D223/16

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract translation: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。组合物和方法用于治疗自身免疫，炎症过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

37.

发明申请
7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES 有权
Title translation: 7-苯氧羰基羧酸衍生物

公开(公告)号：US20120101103A1

公开(公告)日：2012-04-26

申请号：US13141675

申请日：2009-12-18

Applicant: Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess

Inventor： Adam Cook , Kevin W. Hunt , Robert Kirk Delisle , Todd Romoff , Christopher T. Clark , Ganghyeok Kim , Christopher P. Corrette , George A. Doherty , Laurence E. Burgess

IPC: A61K31/498 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/453 , A61K31/444 , A61K31/4433 , A61K31/433 , A61K31/427 , A61K31/428 , A61K31/423 , A61K31/4155 , A61K31/4025 , C07D405/14 , C07D405/12 , C07D417/12 , A61K31/501

CPC classification number: C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12

Abstract: Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.

Abstract translation: 其中A，A1，R1，R7a，R7b，R8和R10具有本说明书中给出的含义的式I化合物：（I）是可用于治疗和预防免疫疾病的DP2受体抑制剂，过敏性疾病如哮喘，过敏性鼻炎和特应性皮炎，以及由前列腺素D2（PGD2）介导的其他炎性疾病。式I化合物还可用于通过产生IL-4，IL-5和/或IL-13来治疗涉及Th2T细胞的疾病或医学病症。

38.

发明授权
8-substituted benzoazepines as toll-like receptor modulators 有权

公开(公告)号：US08153622B2

公开(公告)日：2012-04-10

申请号：US12064193

申请日：2006-08-17

Applicant: George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones

Inventor： George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones

IPC: A61P37/00 , A61K31/55 , C07D223/16 , C07D403/10

CPC classification number: C07D223/16

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.