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公开(公告)号：US20170088613A1
公开(公告)日：2017-03-30
申请号：US15274603
申请日：2016-09-23
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
IPC: C07K16/28 , A61K38/17 , A61K45/06 , C07K16/30 , A61K39/395
CPC classification number: C07K16/28 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/3061 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/70 , C07K2317/75 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , Y02A50/466
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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公开(公告)号：US20170073409A1
公开(公告)日：2017-03-16
申请号：US14718039
申请日：2015-05-20
Applicant: GENENTECH, INC.
Inventor： David P. ARNOTT , Austin L. GURNEY , Philip E. HASS , James M. LEE , Yan WU
IPC: C07K16/24
CPC classification number: C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体和用于产生 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20160168250A1
公开(公告)日：2016-06-16
申请号：US14887042
申请日：2015-10-19
Applicant: GENENTECH, INC.
Inventor： Avi ASHKENAZI , Jing QING , Christian WIESMANN , Yan WU
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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34.发明申请ANTIBODIES DIRECTED TO IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES OF THEREOF 审中-公开针对IL-17A / F异种多肽的抗体及其治疗用途公开(公告)号：US20150232551A1
公开(公告)日：2015-08-20
申请号：US14491641
申请日：2014-09-19
Applicant: GENENTECH, INC.
Inventor： David P. ARNOTT , Austin L. GURNEY , Phillip E. HASS , James M. LEE , Yan WU
CPC classification number: C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体和用于产生 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20240067752A1
公开(公告)日：2024-02-29
申请号：US18474445
申请日：2023-09-26
Applicant: Genentech, Inc.
Inventor： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC: C07K16/40 , A61K39/395
CPC classification number: C07K16/40 , A61K39/3955 , A61K2039/507 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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Patent Agency Ranking
公开(公告)号：US20230287127A1
公开(公告)日：2023-09-14
申请号：US18160094
申请日：2023-01-26
Applicant: Genentech, Inc.
Inventor： Bryan IRVING , Henry CHIU , Heather MAECKER , Sanjeev MARIATHASAN , Sophie M. LEHAR , Yan WU , Jeanne CHEUNG
IPC: C07K16/28 , C07K16/22 , A61K39/00 , A61K39/395 , C07K16/10 , A61K31/7068 , C07K16/30 , A61K45/06
CPC classification number: C07K16/2827 , A61K31/7068 , A61K39/00 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K16/22 , C07K16/28 , C07K16/30 , C07K16/1063 , C07K16/3046 , A61K2039/505 , A61K2039/507 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/565 , C07K2317/567 , Y02A50/30
Abstract: The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
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公开(公告)号：US20210253693A1
公开(公告)日：2021-08-19
申请号：US17244682
申请日：2021-04-29
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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公开(公告)号：US20210032328A1
公开(公告)日：2021-02-04
申请号：US17064464
申请日：2020-10-06
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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公开(公告)号：US20170342163A1
公开(公告)日：2017-11-30
申请号：US15653201
申请日：2017-07-18
Applicant: Genentech, Inc.
Inventor： Yan WU , Menno van LOOKEREN CAMPAGNE , Daniel KIRCHHOFER , Michael Terry LIPARI , Kenneth J. KATSCHKE, Jr. , Paul M. MORAN , Scott STAWICKI , Wei-Ching LIANG
IPC: C07K16/40
CPC classification number: C07K16/40 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.
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公开(公告)号：US20170239366A1
公开(公告)日：2017-08-24
申请号：US15386577
申请日：2016-12-21
Applicant: Genentech, Inc.
Inventor： Steven R. LEONG , Andrew POLSON , Paul POLAKIS , Yan WU , Wei-Ching LIANG , Ron FIRESTEIN
IPC: A61K47/48 , A61K31/5377 , C07K16/30 , A61K31/5517 , A61K39/395 , C07K19/00
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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