Patent search ap:("Genentech Page Inc.") AND inv:"Robert J. JOHNSTON"

1.

发明申请
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 有权

公开(公告)号：US20220064286A1

公开(公告)日：2022-03-03

申请号：US17526338

申请日：2021-11-15

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

2.

发明公开
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 审中-公开

公开(公告)号：US20230279102A1

公开(公告)日：2023-09-07

申请号：US18062956

申请日：2022-12-07

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , A61K38/17 , C07K16/30 , A61K45/06 , A61K39/395

CPC classification number: C07K16/28 , A61K38/177 , A61K39/39558 , A61K45/06 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/3061 , A61K2039/507 , C07K2317/34 , C07K2317/56 , C07K2317/90 , C07K2317/94

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

3.

发明申请
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 有权

公开(公告)号：US20210253693A1

公开(公告)日：2021-08-19

申请号：US17244682

申请日：2021-04-29

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

4.

发明申请
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 有权

公开(公告)号：US20210032328A1

公开(公告)日：2021-02-04

申请号：US17064464

申请日：2020-10-06

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

5.

发明申请
METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS 审中-公开

公开(公告)号：US20170037127A1

公开(公告)日：2017-02-09

申请号：US15239524

申请日：2016-08-17

Applicant: Genentech, Inc.

Inventor： Jane GROGAN , Robert J. JOHNSTON , Bryan IRVING , Jason HACKNEY , Xin YU , Dan EATON , Kristin BOWLES , Laetitia COMPS-AGRAR

IPC: C07K16/28 , A61K45/06 , C07K16/30

CPC classification number: C07K16/2803 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0387 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K14/70596 , C07K16/2818 , C07K16/2827 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2319/30 , Y02A50/466

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

6.

发明申请
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 审中-公开

公开(公告)号：US20190119376A1

公开(公告)日：2019-04-25

申请号：US15994583

申请日：2018-05-31

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , A61K45/06 , A61K38/17 , C07K16/30 , A61K39/395

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

7.

发明申请
ANTI-TIGIT ANTIBODIES AND METHODS OF USE 审中-公开

公开(公告)号：US20180186875A1

公开(公告)日：2018-07-05

申请号：US15895741

申请日：2018-02-13

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN

IPC: C07K16/28 , A61K39/395 , A61K45/06 , C07K16/30 , A61K38/17 , A61K39/00

CPC classification number: C07K16/28 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/3061 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/70 , C07K2317/75 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

8.

发明申请
METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS 有权
Title translation: 使用PD-1轴绑定拮抗剂和TIGIT抑制剂治疗癌症的方法

公开(公告)号：US20150216970A1

公开(公告)日：2015-08-06

申请号：US14333375

申请日：2014-07-16

Applicant: GENENTECH, INC.

Inventor： Jane GROGAN , Robert J. JOHNSTON , Bryan IRVING , Jason HACKNEY , Xin YU , Dan EATON , Kristin BOWLES , Laetitia COMPS-AGRAR

IPC: A61K39/395 , A61K45/06

CPC classification number: C07K16/2803 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , A01K2267/0387 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K14/70596 , C07K16/2818 , C07K16/2827 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2319/30 , Y02A50/466

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

Abstract translation: 本发明描述了包含PD-1轴结合拮抗剂和降低或抑制TIGIT表达和/或活性的试剂的组合治疗及其使用方法，包括治疗需要增强免疫原性的病症的方法，例如增加肿瘤免疫原性治疗癌症或慢性感染。