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公开(公告)号：US20170239366A1
公开(公告)日：2017-08-24
申请号：US15386577
申请日：2016-12-21
Applicant: Genentech, Inc.
Inventor： Steven R. LEONG , Andrew POLSON , Paul POLAKIS , Yan WU , Wei-Ching LIANG , Ron FIRESTEIN
IPC: A61K47/48 , A61K31/5377 , C07K16/30 , A61K31/5517 , A61K39/395 , C07K19/00
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20150166674A1
公开(公告)日：2015-06-18
申请号：US14517682
申请日：2014-10-17
Applicant: GENENTECH, INC.
Inventor： Mark S. DENNIS , Bonnee RUBINFELD , Paul POLAKIS , Aya JAKOBOVITS
IPC: C07K16/40 , A61K38/05 , A61K47/48 , A61K45/06 , A61K39/395
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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公开(公告)号：US20160296634A1
公开(公告)日：2016-10-13
申请号：US14945980
申请日：2015-11-19
Applicant: GENENTECH, INC.
Inventor： Mark DENNIS , William MALLET , Paul POLAKIS
IPC: A61K47/48 , A61K31/555 , C07K16/30 , A61K31/4196 , A61K31/519 , A61K31/517 , A61K31/7068 , A61K31/513
CPC classification number: A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及可用于诊断和治疗哺乳动物肿瘤的物质的抗体药物共轭组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20160168261A1
公开(公告)日：2016-06-16
申请号：US14953763
申请日：2015-11-30
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , Jan MARIK , Paul POLAKIS , Bonnee RUBINFELD , Simon WILLIAMS
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
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Patent Agency Ranking
公开(公告)号：US20170234883A1
公开(公告)日：2017-08-17
申请号：US15415379
申请日：2017-01-25
Applicant: Genentech, Inc.
Inventor： Mark S. DENNIS , Bonnee RUBINFELD , Paul POLAKIS , Aya JAKOBOVITS
IPC: G01N33/574 , C07K16/40
CPC classification number: G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
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6.发明申请CYSTEINE ENGINEERED ANTI-TENB2 ANTIBODIES AND ANTIBODY DRUG CONJUGATES 审中-公开CYSTEINE工程抗TENB2抗体和抗体药物联合公开(公告)号：US20150158952A1
公开(公告)日：2015-06-11
申请号：US14552244
申请日：2014-11-24
Applicant: GENENTECH, INC.
Inventor： Weiguang MAO , Jagath Reddy JUNUTULA , Paul POLAKIS
CPC classification number: C07K16/28 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/40 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492
Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
Abstract translation: 通过用非交联的反应性半胱氨酸氨基酸替代亲本抗TENB2抗体的一个或多个氨基酸来工程化半胱氨酸改造的抗TENB2抗体。 提供了设计，制备，筛选和选择半胱氨酸改造的抗TENB2抗体的方法。 半胱氨酸改造的抗TENB2抗体（Ab）通过接头（L）与一个或多个药物部分（D）缀合以形成具有式I：Ab-（LD）p I的半胱氨酸改造的抗TENB2抗体 - 药物共轭物，其中p 公开了半胱氨酸改造的抗体药物化合物和组合物的诊断和治疗用途。
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公开(公告)号：US20180344864A1
公开(公告)日：2018-12-06
申请号：US15846083
申请日：2017-12-18
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , William MALLET , Paul POLAKIS
IPC: A61K47/68 , A61K31/7068 , A61K31/337 , C07K16/30 , A61K45/06 , A61K38/08 , A61K38/07 , A61K31/7072 , A61K31/555 , A61K31/537 , A61K31/519 , A61K31/517 , A61K31/513 , A61K31/4196 , A61K31/4025 , A61K39/00
CPC classification number: A61K31/7068 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6803 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
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8.发明申请公开(公告)号：US20170349639A1
公开(公告)日：2017-12-07
申请号：US15385528
申请日：2016-12-20
Applicant: Genentech, Inc.
Inventor： James A. ERNST , Paul POLAKIS , Bonnee RUBINFELD , Venita I. DEALMEIDA
CPC classification number: C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
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公开(公告)号：US20170121424A1
公开(公告)日：2017-05-04
申请号：US15289485
申请日：2016-10-10
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , Jan MARIK , Paul POLAKIS , Bonnee RUBINFELD , Simon WILLIAMS
IPC: C07K16/40 , C07B59/00 , G01N33/574 , G01N33/534 , G01N33/60 , A61K51/10 , C07K16/30
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
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