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公开(公告)号：US12139475B2
公开(公告)日：2024-11-12
申请号：US17816614
申请日：2022-08-01
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC: C07D405/04 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P35/00 , C07D209/34 , C07D401/04 , C07D405/14
Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US11603356B2
公开(公告)日：2023-03-14
申请号：US17091001
申请日：2020-11-06
Applicant: CHEMOCENTRYX, INC.
Inventor： Kwok Yau , Kenken Luong , Rajinder Singh , Yibin Zeng , Penglie Zhang , Manmohan Reddy Leleti , Rebecca M. Lui
IPC: C07D211/60 , A61K9/00
Abstract: Provided herein is an amorphous form of a complement component 5a receptor having the formula of Compound 1 Also provided herein are pharmaceutical compositions and methods of treatment using the amorphous form of Compound 1, described herein.
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公开(公告)号：US11040960B2
公开(公告)日：2021-06-22
申请号：US16438880
申请日：2019-06-12
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC: C07D405/12 , A61P11/00 , A61P37/00 , A61P17/06 , A61P35/00 , A61K31/4035 , A61K31/4439 , A61K45/06 , C07B59/00 , C07D405/14 , C07D413/12 , A61K31/422
Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US10660897B2
公开(公告)日：2020-05-26
申请号：US16030729
申请日：2018-07-09
Applicant: CHEMOCENTRYX, INC.
Inventor： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/10 , C07D413/12 , C07D211/60 , C07D413/14 , C07D401/12
Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US10407417B2
公开(公告)日：2019-09-10
申请号：US15674230
申请日：2017-08-10
Applicant: CHEMOCENTRYX, INC.
Inventor： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC: A01N43/00 , A61K31/00 , C07D413/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
Abstract: Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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Patent Agency Ranking
公开(公告)号：US10035768B2
公开(公告)日：2018-07-31
申请号：US15722819
申请日：2017-10-02
Applicant: CHEMOCENTRYX, INC.
Inventor： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC: C07D211/60 , C07D413/12 , C07D405/10 , C07D401/12 , C07D401/10 , C07D401/06 , A61K31/5377 , A61K31/4545 , A61K31/454 , A61K31/451 , A61K31/445 , C07D413/14 , C07D401/14 , C07D405/12
CPC classification number: C07D211/60 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D413/12 , C07D413/14
Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
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公开(公告)号：US09758512B2
公开(公告)日：2017-09-12
申请号：US15207315
申请日：2016-07-11
Applicant: CHEMOCENTRYX, INC.
Inventor： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC: A01N43/00 , A61K31/00 , C07D413/06 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
CPC classification number: C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
Abstract: Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US20170144997A1
公开(公告)日：2017-05-25
申请号：US15353889
申请日：2016-11-17
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi CHEN , Dean R. DRAGOLI , Junfa FAN , Jaroslaw KALISIAK , Antoni KRASINSKI , Manmohan Reddy Leleti , Venkat MALI , Jeffrey McMAHON , Rajinder SINGH , Hiroko TANAKA , Ju YANG , Chao YU , Penglie ZHANG
IPC: C07D405/14 , A61K31/341 , A61K45/06 , C07D405/12 , A61K31/4725 , A61K31/4155 , A61K31/4439 , C07D209/46 , A61K31/506 , A61K31/454 , C07D307/52 , A61K31/4035
CPC classification number: C07D405/14 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
Abstract: Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US20150175547A1
公开(公告)日：2015-06-25
申请号：US14557949
申请日：2014-12-02
Applicant: ChemoCentryx, Inc.
Inventor： Daniel Dairaghi , Dean R. Dragoli , Jarek Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC: C07D215/48 , C07D405/14 , C07D405/04
CPC classification number: A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
Abstract translation: 提供式（I）化合物，其可用于治疗至少部分由CCR6调节的疾病或病症：
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公开(公告)号：US20150141425A1
公开(公告)日：2015-05-21
申请号：US14531385
申请日：2014-11-03
Applicant: ChemoCentryx, Inc.
Inventor： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC: C07D211/60 , C07D401/12 , C07D401/10 , C07D401/06
CPC classification number: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
Abstract translation: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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