-
公开(公告)号：US11820759B2
公开(公告)日：2023-11-21
申请号：US17192810
申请日：2021-03-04
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
CPC分类号： C07D405/14 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , A61P35/00 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
-
公开(公告)号：US11684606B2
公开(公告)日：2023-06-27
申请号：US17527939
申请日：2021-11-16
申请人： CHEMOCENTRYX, INC.
发明人： James J. Campbell , Karen Ebsworth , Antoni Krasinski , Venkat Reddy Mali , Jeffrey McMahon , Rajinder Singh , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K31/4035 , A61P29/00 , A61P17/06
CPC分类号： A61K31/4035 , A61P17/06 , A61P29/00
摘要： The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula:
-
公开(公告)号：US10759789B2
公开(公告)日：2020-09-01
申请号：US16524618
申请日：2019-07-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K31/404 , A61K31/4439 , C07D405/14 , C07D405/04 , C07D401/04 , C07D209/34 , A61P1/00 , A61P19/00 , A61P17/00 , A61P35/00 , A61P11/00
摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
-
公开(公告)号：US11945805B2
公开(公告)日：2024-04-02
申请号：US17243872
申请日：2021-04-29
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/00 , C07D405/14 , C07D413/12
CPC分类号： C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/002 , C07D405/14 , C07D413/12 , C07B2200/05 , A61K31/4035 , A61K2300/00 , A61K31/422 , A61K2300/00 , A61K31/4439 , A61K2300/00
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
-
公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
摘要： Compounds are provided as chemokine inhibitors having the structure:
-
公开(公告)号：US10370363B2
公开(公告)日：2019-08-06
申请号：US15722785
申请日：2017-10-02
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC分类号： A61K45/06 , C07B59/00 , A61K31/422 , C07D405/12 , C07D405/14 , C07D413/12 , A61K31/4035 , A61K31/4439
摘要： Compounds are provided as inhibitors of CXCR2, having the structure:
-
公开(公告)号：US11434230B2
公开(公告)日：2022-09-06
申请号：US16932114
申请日：2020-07-17
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D405/04 , C07D209/34 , C07D401/04 , A61P1/00 , A61P11/00 , A61P7/00 , A61P19/00 , A61P35/00 , A61K31/404 , A61K31/4439 , C07D405/14 , A61P17/00
摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
-
公开(公告)号：US11207294B2
公开(公告)日：2021-12-28
申请号：US16241469
申请日：2019-01-07
申请人： CHEMOCENTRYX, INC.
发明人： James J. Campbell , Karen Ebsworth , Antoni Krasinski , Venkat Reddy Mali , Jeffrey McMahon , Rajinder Singh , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K31/4035 , A61P17/06 , A61P29/00
摘要： The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C—X—C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C—X—C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula:
-
公开(公告)号：US10421748B2
公开(公告)日：2019-09-24
申请号：US15914900
申请日：2018-03-07
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： C07D209/34 , C07D405/04 , A61K31/404 , A61K31/4439 , C07D405/14 , C07D401/04
摘要： Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
-
公开(公告)号：US10336736B2
公开(公告)日：2019-07-02
申请号：US15794800
申请日：2017-10-26
申请人： CHEMOCENTRYX, INC.
发明人： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC分类号： A61K45/06 , A61K31/341 , A61K31/454 , A61K31/506 , C07D209/46 , C07D307/52 , C07D405/12 , C07D405/14 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/4725
摘要： Compounds are provided as chemokine inhibitors having the structure:
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.018 秒)
