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公开(公告)号：US11951214B2
公开(公告)日：2024-04-09
申请号：US17545878
申请日：2021-12-08
Applicant: CHEMOCENTRYX, INC.
Inventor： Manmohan Reddy Leleti , Jay P. Powers
IPC: A61K9/48 , A61K31/4412
CPC classification number: A61K9/4858 , A61K9/4808 , A61K9/4825 , A61K9/4833 , A61K31/4412
Abstract: The present disclosure provides solid solution capsule formulations of Compound 1
and methods of making the same. Also provided herein are methods of treating individuals suffering from or susceptible to a disease or disorder involving pathologic activation of C5a receptors by administering an effective amount of one or more solid solution capsules comprising Compound 1. Further provided herein are singe unit dosage capsules comprising certain amounts of Compound 1, and kits comprising a solid solution capsule comprising Compound 1.
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公开(公告)号：US11434230B2
公开(公告)日：2022-09-06
申请号：US16932114
申请日：2020-07-17
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi Chen , Dean R. Dragoli , Pingchen Fan , Manmohan Reddy Leleti , Rebecca M. Lui , Viengkham Malathong , Jay P. Powers , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC: C07D405/04 , C07D209/34 , C07D401/04 , A61P1/00 , A61P11/00 , A61P7/00 , A61P19/00 , A61P35/00 , A61K31/404 , A61K31/4439 , C07D405/14 , A61P17/00
Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
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公开(公告)号：US09795599B2
公开(公告)日：2017-10-24
申请号：US15074965
申请日：2016-03-18
Applicant: ChemoCentryx, Inc.
Inventor： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC: C07D405/04 , C07D405/14 , A61K31/4709 , C07D215/48 , A61K31/47
CPC classification number: A61K31/47 , A61K31/4709 , C07D215/48 , C07D405/04 , C07D405/14
Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
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公开(公告)号：US20160317545A1
公开(公告)日：2016-11-03
申请号：US15207315
申请日：2016-07-11
Applicant: CHEMOCENTRYX, INC.
Inventor： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC: A61K31/5377 , A61K31/495 , A61K31/454 , A61K31/496 , A61K31/4545 , A61K31/451
CPC classification number: C07D413/06 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/70 , C07D241/04 , C07D295/135 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D417/04
Abstract: Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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5.发明授权
公开(公告)号：US09150550B2
公开(公告)日：2015-10-06
申请号：US14056702
申请日：2013-10-17
Applicant: ChemoCentryx, Inc.
Inventor： Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jay Powers , Ju Yang
IPC: C07D403/14 , C07D401/14 , C07D403/12 , C07D401/04
CPC classification number: C07D401/14 , C07D235/06 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14
Abstract: Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
Abstract translation: 提供了与CCR（4）结合的苯并咪唑，苯并吡唑和苯并三唑化合物，可用于治疗过敏性疾病，自身免疫性疾病，移植排斥和癌症等疾病。
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公开(公告)号：US08906938B2
公开(公告)日：2014-12-09
申请号：US13894209
申请日：2013-05-14
Applicant: ChemoCentryx, Inc.
Inventor： Pingchen Fan , Kevin Lloyd Greenman , Manmohan Reddy Leleti , Yandong Li , Jay P. Powers , Hiroko Tanaka , Ju Yang , Yibin Zeng
IPC: A61K31/445 , C07D211/60 , A61K31/454 , C07D413/14 , C07D401/10 , A61K31/5377 , C07D405/10 , C07D401/06 , C07D401/14 , A61K31/451 , C07D413/12 , A61K31/4545
CPC classification number: A61K31/5377 , A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D413/12 , C07D413/14
Abstract: Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
Abstract translation: 提供了作为C5a受体调节剂的化合物。 化合物是取代的哌啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。
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公开(公告)号：US11945805B2
公开(公告)日：2024-04-02
申请号：US17243872
申请日：2021-04-29
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Manmohan Reddy Leleti , Viengkham Malathong , Jeffrey McMahon , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang , Venkat Mali
IPC: C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/00 , C07D405/14 , C07D413/12
CPC classification number: C07D405/12 , A61K31/4035 , A61K31/422 , A61K31/4439 , A61K45/06 , A61P11/00 , A61P17/06 , A61P35/00 , A61P37/00 , C07B59/002 , C07D405/14 , C07D413/12 , C07B2200/05 , A61K31/4035 , A61K2300/00 , A61K31/422 , A61K2300/00 , A61K31/4439 , A61K2300/00
Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
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公开(公告)号：US11142521B2
公开(公告)日：2021-10-12
申请号：US16526338
申请日：2019-07-30
Applicant: CHEMOCENTRYX, INC.
Inventor： Trevor T. Charvat , Junfa Fan , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Venkat Reddy Mali , Jeffrey P. McMahon , Jay Powers , Sreenivas Punna , Ju Yang
IPC: C07D413/06 , C07D401/04 , C07D403/06 , C07D405/06 , C07D417/04 , C07D211/56 , C07D295/135 , C07D211/62 , C07D401/06 , C07D211/26 , C07D211/70 , C07D241/04 , C07D207/16 , C07D211/34 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377
Abstract: Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
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公开(公告)号：US10988464B2
公开(公告)日：2021-04-27
申请号：US16414272
申请日：2019-05-16
Applicant: CHEMOCENTRYX, INC.
Inventor： Xi Chen , Dean R. Dragoli , Junfa Fan , Jaroslaw Kalisiak , Antoni Krasinski , Manmohan Reddy Leleti , Venkat Mali , Jeffrey McMahon , Rajinder Singh , Hiroko Tanaka , Ju Yang , Chao Yu , Penglie Zhang
IPC: C07D405/14 , A61P35/00 , A61K31/341 , A61K31/4035 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D209/46 , C07D307/52 , C07D405/12
Abstract: Compounds are provided as chemokine inhibitors having the structure:
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公开(公告)号：US10786494B2
公开(公告)日：2020-09-29
申请号：US16150796
申请日：2018-10-03
Applicant: CHEMOCENTRYX, INC.
Inventor： Daniel Dairaghi , Dean R. Dragoli , Jaroslaw Kalisiak , Christopher W. Lange , Manmohan Reddy Leleti , Yandong Li , Rebecca M. Lui , Venkat Reddy Mali , Viengkham Malathong , Jay P. Powers , Hiroko Tanaka , Joanne Tan , Matthew J. Walters , Ju Yang , Penglie Zhang
IPC: A61K31/47 , C07D215/48 , C07D405/04 , C07D405/14 , A61K31/4709
Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
