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公开(公告)号：US20150013593A1
公开(公告)日：2015-01-15
申请号：US14377173
申请日：2013-02-04
Applicant: Universiteit Leiden
Inventor： Guocai Dong
CPC classification number: C30B25/16 , B82Y30/00 , B82Y40/00 , C01B32/186 , C23C16/26 , C30B29/02 , H01L21/02425 , H01L21/02433 , H01L21/02527 , H01L21/0262
Abstract: A method of forming a graphene film on a surface (20) of a substrate comprises the steps of: (i) locating a carbon source (22) at, or in a vicinity of the surface (20) of the substrate; (ii) controlling ambient conditions at the surface (20) of the substrate to inhibit graphene nucleation on the surface (20); (iii) applying a temporary change of one or more of the ambient conditions at a localised site (30) on the surface (20) of the substrate to initiate graphene nucleation at the localised site (30); (iv) controlling the ambient conditions at the surface (20) of the substrate, following initiation of graphene nucleation at the localised site, to simultaneously inhibit graphene nucleation and enable graphene growth on the surface (20).
Abstract translation: 在衬底的表面（20）上形成石墨烯膜的方法包括以下步骤：（i）将碳源（22）定位在衬底的表面（20）附近或附近; （ii）控制所述衬底的表面（20）处的环境条件以抑制所述表面（20）上的石墨烯成核; （iii）在衬底的表面（20）上的局部位置（30）处施加一个或多个环境条件的暂时变化，以在所述局部位置（30）处引发石墨烯成核; （iv）在局部位置开始石墨烯成核之后，控制衬底表面（20）处的环境条件，同时抑制石墨烯成核并使表面上的石墨烯生长（20）。
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公开(公告)号：US20140341934A1
公开(公告)日：2014-11-20
申请号：US14451845
申请日：2014-08-05
Applicant: Universiteit Leiden
Inventor： Jacob van Spronsen , Geert-Jan Witkamp , Frank Hollman , Young Hae Choi , Robert Verpoorte
IPC: C09K3/00 , C07H17/07 , C07D311/62
CPC classification number: C09K3/00 , B01D11/0288 , B01D11/04 , C07D311/62 , C07H17/07
Abstract: The invention is directed to a process for extracting materials from biological material, which process is characterized in that the naturally occurring biological material is treated with an extractant consisting of a deep eutectic solvent of natural origin or a an ionic liquid of natural origin to produce a biological extract of natural origin dissolved in the said solvent or ionic liquid.
Abstract translation: 本发明涉及从生物材料中提取材料的方法，该方法的特征在于天然存在的生物材料用天然来源的深共晶溶剂或天然来源的离子液体组成的萃取剂处理，以产生 天然来源的生物提取物溶解在所述溶剂或离子液体中。
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公开(公告)号：US20040063640A1
公开(公告)日：2004-04-01
申请号：US10246424
申请日：2002-09-19
Applicant: UNIVERSITEIT LEIDEN
Inventor： Danny Burg , Gerard Johan Mulder
IPC: A61K038/05 , A61K038/04 , C07K005/06 , C07K005/04 , C07D213/55
CPC classification number: C07D213/32 , A61K38/06 , A61K38/063 , C07K5/0606 , C07K5/0819
Abstract: The invention relates to peptidomimetic compounds with formula 1 wherein ZnullCH2 and YnullCH2, or ZnullO and YnullCnullC), which are novel analogs of glutathion and are inhibitors of glutathione S-tansferase, in particular of GST P1-1. Such inhibition has beneficial effects in therapy against cancer. In particular compounds in which R3 is H, R4 is benzyl and R5 is phenyl are stable towards nullGT activity and are selective for GST P1-1.
Abstract translation: 本发明涉及具有下式的拟肽化合物，其中Z = CH 2和Y = CH 2，或Z = O和Y = C = C），其是谷胱甘肽的新型类似物，并且是谷胱甘肽S-转移酶的抑制剂，特别是GST P1- 1。 这种抑制在治疗癌症方面具有有益的作用。 特别是其中R 3为H，R 4为苄基且R 5为苯基的化合物对γGT活性稳定，对GST P1-1具有选择性。
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公开(公告)号：US12209979B2
公开(公告)日：2025-01-28
申请号：US17786238
申请日：2020-12-21
Applicant: UNIVERSITEIT LEIDEN
Inventor： Pauline Marthe Gerardina Van Deursen , Gregory Fabrice Schneider , Alexander Kros , Viorica Tudor
IPC: G01N23/2202 , G01N1/28 , H01J37/20
Abstract: A thin film liquid cell suitable for transmission electron microscopy at room temperature is fabricated as follows. A thin film floating on a liquid is prepared. A droplet of the liquid with the thin film floating thereon is transferred to a support by means of a loop. The loop carries the droplet and the droplet carries the thin film during this transfer. Sufficient liquid from the droplet on the support is removed to form the thin film liquid cell.
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公开(公告)号：US20240247024A1
公开(公告)日：2024-07-25
申请号：US18553278
申请日：2022-03-30
Applicant: UNIVERSITEIT LEIDEN
Inventor： Nathaniel I. Martin , Yonghzi Gao , Matthijs Van Haren , Ned Buijs , Richard Bramwell Parsons , Monica Emanuelli , Davide Sartini
IPC: C07H19/173 , A61K31/7076 , A61P35/00
CPC classification number: C07H19/173 , A61K31/7076 , A61P35/00
Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Nicotinamide N-methyltransferase (NNMT), and formulations composing such compounds. The compounds and formulations may be used as a medicament, for example in the treatment of cancer, metabolic disease, or neurodegenerative disease. The compounds may be of formula (I).
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Patent Agency Ranking
公开(公告)号：US20230393090A1
公开(公告)日：2023-12-07
申请号：US18032011
申请日：2021-10-13
Applicant: UNIVERSITEIT LEIDEN
Inventor： Gerard Jacob Pieter van WESTEN , Hans Michiel de BRUIJN , Gregory Fabrice SCHNEIDER , Xuhan LIU , Erik Pieter van GEEST , Sylvestre Antoíne BONNET
IPC: G01N27/414 , G01N33/00
CPC classification number: G01N27/4141 , G01N27/04 , G01N33/0034
Abstract: There is provided a gas sensing apparatus (30) for sensing one or more analytes in a gas or gas mixture. The gas sensing apparatus (30) comprises: a plurality of sensors (32), each sensor (32) including a polymer layer (42), each polymer layer (42) made of a respective different type of chemically non-selective or semi-selective polymer; and a measurement device (38) configured to measure a change in parameter of each sensor (32) responsive to interaction of an analyte with the respective polymer layer (42).
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公开(公告)号：US20230174584A1
公开(公告)日：2023-06-08
申请号：US17761376
申请日：2020-09-24
Applicant: UNIVERSITEIT LEIDEN
Inventor： Nathaniel I. Martin , Emma Van Groesen , Kamaleddin H.M.E. Tehrani , Nicola Wade
Abstract: Provided herein are lipidated glycopeptide compounds of formula (I); or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. R1 is a lipid, R2 is —H or a lipid, and R3 and R4 are as defined herein. These compounds have antibiotic activity. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may also be used in the treatment of bacterial infection.
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公开(公告)号：US11525140B2
公开(公告)日：2022-12-13
申请号：US16087199
申请日：2017-03-23
Inventor： Marcel Tijsterman , Maartje Van Kregten , Paul Hooykaas
IPC: C12N15/82
Abstract: The present disclosure provides methods for transfecting plants and for expressing RNA or polypeptide molecules in plants. In particular, plants having reduced POLQ expression and/or activity are transfected in order to reduce random integration events. The disclosure further provides transfected plants and plant progeny produced by the methods disclosed herein.
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39.发明申请公开(公告)号：US20220230757A1
公开(公告)日：2022-07-21
申请号：US17612866
申请日：2020-05-22
Applicant: UNIVERSITEIT LEIDEN
Inventor： Arko GHOSH
Abstract: A method of monitoring a user's neuronal activity (10) includes recording a user's behavioural output with a portable electronic device, such as a mobile cellphone. The user's behavioural output (14) is compared (18) with predefined behavioural outputs associated with known event-related neuronal activations (20). The user's event-related neuronal activation (22) is determined based upon the comparison so as to provide an indication of the user's neuronal activity.
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公开(公告)号：US20220064231A1
公开(公告)日：2022-03-03
申请号：US17276452
申请日：2019-09-17
Inventor： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
IPC: C07K14/46
Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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