公开(公告)号：US12105001B2

公开(公告)日：2024-10-01

申请号：US17789611

申请日：2020-12-21

Applicant: LIFY AIR ,  CENTRE NATIONAL LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS

Inventor： Jérôme Richard ,  Johann Lauthier ,  Jean-Baptiste Renard

IPC: G01N15/06 ,  G01N15/00 ,  G01N15/0205 ,  G01N15/075 ,  G01N21/47 ,  G01N21/53 ,  G01N33/00

CPC classification number: G01N15/06 ,  G01N15/0211 ,  G01N21/53 ,  G01N33/0031 ,  G01N2015/0046 ,  G01N2015/0238 ,  G01N15/075 ,  G01N2021/4711 ,  G01N2021/4733

Abstract: A device for detecting the presence of pollen in the air, including a measuring chamber isolated from external light, an arrangement configured to drive an air flow through the measuring chamber, and a light source emitting a light beam in a direction of propagation through the air flow, into the measuring chamber. The device includes at least four photosensitive sensors configured to measure the luminous flux diffused by the illuminated air flow, in four different directions, a clock, at least two meteorological sensors, and at least one computer capable of determining the nature of a pollen particle present in the air from the data measured by the photosensitive sensors, the clock and the meteorological sensors.

公开(公告)号：US11932638B2

公开(公告)日：2024-03-19

申请号：US16615947

申请日：2018-05-23

Applicant: Centre National de la Recherche Scientifique ,  Universite d'Orleans ,  Université de Tours ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  CHU Nantes

Inventor： Sylvain Routier ,  Frédéric Buron ,  Nuno Rodrigues ,  Gaëlle Fourriere-Grandclaude ,  Christophe Vandier ,  Aurélie Chantome ,  Marie Potier-Cartereau ,  Maxime Gueguinou ,  Séverine Marionneau-Lambot

IPC: C07D471/04 ,  A61P35/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D471/04 ,  A61P35/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention concerns a compound of following general formula (I):






where:

either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group,

R1 particularly being H or (C1-C6)alkyl group;
A1 being an —NH— radical or —NH—CH2— radical;
Cy1 particularly being a phenyl group,


A is a fused (hetero)aromatic ring having 5 to 7 atoms,


for use for treating cancer.

公开(公告)号：US20230312576A1

公开(公告)日：2023-10-05

申请号：US17999749

申请日：2021-05-25

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS

Inventor： Sylvain ROUTIER ,  Hélène BENEDETTI ,  Béatrice LÉE-MÉHEUST ,  Pascal BONNET ,  Karen PLÉ ,  Samia ACI-SÈCHE ,  Sandrine RUCHAUD ,  Abdennour BRAKA ,  Anthony CHAMPIRÉ ,  Christian ANDRES ,  Patrick VOURC'H

IPC: C07D487/04 ,  C07D495/14 ,  C07D471/14 ,  A61P25/28

CPC classification number: C07D487/04 ,  C07D495/14 ,  C07D471/14 ,  A61P25/28

Abstract: The present invention concerns a compound of formula (1), in particular as LIMK and/or ROCK kinases inhibitors. The present invention also concerns these new inhibitors for use for the treatment of a condition selected in the group consisting of: cancers, virion infections, ocular hypertension and glaucoma formation, Neurofibromatosis type 1 and 2, psoriatic lesions, inflammatory diseases and hyperalgesia, central sensitization and chronic pain, reproduction erectile dysfunction, and neuronal diseases.

公开(公告)号：US11489188B2

公开(公告)日：2022-11-01

申请号：US16649796

申请日：2018-09-25

Applicant: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS

Inventor： Julien Vulliet ,  Anne-Lise Thomann ,  Pierre-Laurent Coddet

IPC: C23C14/58 ,  H01M8/1253 ,  C23C14/08 ,  C23C14/35 ,  H01M8/126

Abstract: A method of manufacturing by magnetron cathode sputtering an electrolyte film for use in solid oxide cells (SOC). This method comprises the steps consisting of heating a substrate to a temperature ranging from 200° C. to 1200° C.; followed by subjecting the substrate to at least two treatment cycles, each treatment cycle comprising: 1) depositing one layer of a metal precursor on the substrate by magnetron cathode sputtering of a target made up of the metal precursor, the sputtering being carried out under elemental sputtering conditions; followed by 2) oxidation-crystallisation of the metal precursor forming the layer deposited on the substrate in the presence of oxygen to obtain the transformation of the metal precursor into the electrolyte material; and in that the substrate is kept at a temperature ranging from 200° C. to 1200° C. for the entire duration of each treatment cycle.

公开(公告)号：US11120999B2

公开(公告)日：2021-09-14

申请号：US16770084

申请日：2018-12-11

Applicant: TOKYO ELECTRON LIMITED ,  UNIVERSITE D'ORLEANS

Inventor： Koichi Yatsuda ,  Kaoru Maekawa ,  Nagisa Sato ,  Kumiko Ono ,  Shigeru Tahara ,  Jacques Faguet ,  Remi Dussart ,  Thomas Tillocher ,  Philippe Lefaucheux ,  Gaëlle Antoun

IPC: H01L21/311 ,  H01L21/3065 ,  H01J37/32

Abstract: A plasma etching method includes a physisorption step for causing an adsorbate that is based on first processing gas to be physisorbed onto a film to be etched, while cooling an object to be processed on which the film to be etched is provided; and an etching step for etching the film to be etched by causing the adsorbate to react with the film to be etched, using the plasma of second processing gas.

公开(公告)号：US20210079031A1

公开(公告)日：2021-03-18

申请号：US17050263

申请日：2019-04-23

Applicant: Centre national de la recherche scientifique ,  UNIVERSITE D'ORLEANS ,  NEOVIRTECH

Inventor： Luigi AGROFOGLIO ,  Vincent ROY ,  Coralie DE SCHUTTER ,  Maxime BESSIERES ,  Franck GALLARDO

IPC: C07F9/6521 ,  C07F9/6512 ,  A61P31/12

Abstract: The present invention concerns a compound having the following formula (I): as well as its use as a medicament, especially for its use for treating viral infections.

公开(公告)号：US20190282563A1

公开(公告)日：2019-09-19

申请号：US16461644

申请日：2017-11-17

Applicant: Centre National de la Recherche Scientifique ,  Universite de Rennes 1 ,  Universite d'Orleans

Inventor： Katherine YAACOUB ,  Thierry GUILLAUDEUX ,  Richard DANIELLOU ,  Pierre LAFITE ,  Samia ACI-SECHE ,  Pascal BONNET

IPC: A61K31/4745 ,  A61K31/655 ,  A61K31/4725 ,  A61K31/381 ,  A61K31/554 ,  A61K31/235 ,  A61K31/341 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides nine selective c-FLIP inhibitors that are useful in the treatment of cancer, alone or in combination with other chemotherapeutic agents, in particular with TRAIL-based chemotherapeutic agents. The present invention also relates to pharmaceutical compositions and kits comprising at least one of the nine selective c-FLIP inhibitors and their use in methods for the treatment of cancer, in particular to overcome chemoresistance or to improve sensitivity of tumors to TRAIL-based therapy.

公开(公告)号：US20180030047A1

公开(公告)日：2018-02-01

申请号：US15507028

申请日：2015-08-26

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS ,  JAGIELLONIAN UNIVERSITY

Inventor： Olivier MARTIN ,  Estelle GALLIENNE-BOIVINEAU ,  Cyril NICOLAS ,  Piotr B. HECZKO ,  Grazyna STOCHEL ,  Magdalena STRUS ,  Agnieszka KYZIOL ,  Diana MIKOLAJCZYK ,  Agnieszka MACHUL

IPC: C07D471/04 ,  A61K31/40 ,  A01N43/36 ,  C07D211/40 ,  A61K31/551 ,  A01N43/40 ,  A61K31/437 ,  A01N43/90 ,  C07D487/04 ,  C07D207/12 ,  A61K31/445

Abstract: Disclosed are compounds of the following formula I: wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple bond or a radical —CHR1— wherein R1 represents: a hydrogen atom, or a linear or branched, possibly interrupted by up to 3 heteroatoms selected from O, S or N and/or possibly substituted, (C1-C12)-alkyl, R2, R3 and R4 represent independently from each other: a hydrogen atom, or a linear or branched (C1-C12)-alkyl or (C1-C12)-acyl R5 represents: a hydrogen atom, or a linear or branched, possibly substituted, (C1-C13)-alkyl possibly interrupted by up to 3 heteroatoms selected from O, S or N, R6 represents: a hydrogen atom, or a linear or branched possibly substituted (C1-C12)-alkyl, possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, for their use as antibacterial drugs.

公开(公告)号：US20170319727A1

公开(公告)日：2017-11-09

申请号：US15529430

申请日：2015-11-26

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (CNRS) ,  UNIVERSITE D'ORLEANS ,  INEL

Inventor： Jean-Michel POUVESLE ,  Eric ROBERT ,  Sebastien DOZIAS ,  Michel HUGNOT ,  Vanessa SARRON ,  Thibault DARNY

IPC: A61L2/14 ,  H05H1/46

Abstract: The invention relates to a method (S) for generating a plurality of cold-plasma jets at atmospheric pressure in order to treat a target (2), wherein said method includes the following steps: producing (S1) a primary cold-plasma jet (3) at atmospheric pressure using a plasma source (10); placing (S2) a substrate (20, 21, 30, 32, 34) near the target (2) to be treated, said substrate (20, 21, 30, 32, 34) including at least two through-holes; and passing (S3) the plasma through the through-holes (22) of the substrate (20) such as to generate at least two secondary cold-plasma jets (4) at atmospheric pressure.

公开(公告)号：US09751838B2

公开(公告)日：2017-09-05

申请号：US14432768

申请日：2013-09-17

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PAUL SABATIER TOULOUSE III ,  UNIVERSITE PARIS-SUD ,  UNIVERSITE D'ORLEANS

Inventor： Frank Lezoualc'h ,  Rodolphe Fischmeister ,  Malik Bisserier ,  Pascal Bouyssou ,  Jean-Paul Blondeau ,  Delphine Courilleau

IPC: A01N43/42 ,  A61K31/47 ,  C07D215/14 ,  C07D215/08 ,  C07D215/18

CPC classification number: C07D215/14 ,  A61K31/47 ,  C07D215/08 ,  C07D215/18

Abstract: The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.