公开(公告)号：US20120122132A1

公开(公告)日：2012-05-17

申请号：US13202131

申请日：2010-02-19

Applicant: Sunyoung Kim

Inventor： Sunyoung Kim

IPC: C12Q1/34

CPC classification number: C12Q1/34 ,  A61B5/0059 ,  A61K31/198 ,  A61K31/505 ,  A61K31/506 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/574 ,  G01N2333/914 ,  G01N2500/04 ,  G01N2800/52

Abstract: A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target, based on the effect of natural polymorphic sequence variation on the conformation of the protein. This method has an advantage over the current genomics-based screening, as the new method provides a direct readout of the structural, and hence functional, outcome of polymorphisms to the protein region targeted by drugs. It allows rapid measurement of a protein's susceptibility to therapeutic targeted agents, prior to using the drug as treatment in the patient. This method can be used to identify biomarkers for a response for a protein to a drug which can be readily tested, interpreted, and used in a clinical setting.

Abstract translation: 基于天然多态性序列变异对蛋白质构象的影响，开发了一种快速的红外光谱方法，以评估靶向化学治疗剂对多肽靶结构的功效。 该方法相对于目前基于基因组学的筛选具有优势，因为新方法提供了针对药物的蛋白质区域的多态性的结构，从而功能性的结果的直接读出。 在使用药物作为患者的治疗之前，它可以快速测量蛋白质对治疗性靶向药物的敏感性。 该方法可用于鉴定蛋白质对药物的响应的生物标志物，其可以容易地在临床环境中测试，解释和使用。

公开(公告)号：US20110025680A1

公开(公告)日：2011-02-03

申请号：US12645478

申请日：2009-12-22

Applicant: Sunyoung Kim ,  Yongwon Jo

Inventor： Sunyoung Kim ,  Yongwon Jo

IPC: G09G5/00

CPC classification number: G09G3/3648 ,  G09G2320/0242 ,  G09G2320/0252 ,  G09G2320/0261 ,  G09G2340/16

Abstract: A liquid crystal display including a first over-driving (OD) compensation unit compensating R data at a first OD rate; a second OD compensation unit compensating G data at a second OD rate; and a third OD compensation unit compensating B data at a third OD rate, where the second OD rate is higher than the first OD rate and the third OD rate.

Abstract translation: 一种液晶显示器，包括以第一OD速率补偿R数据的第一过驱动（OD）补偿单元; 第二OD补偿单元，以第二OD速率补偿G数据; 以及第三OD补偿单元，以第三OD率补偿B数据，其中第二OD率高于第一OD率和第三OD率。

公开(公告)号：US20100111927A1

公开(公告)日：2010-05-06

申请号：US12180723

申请日：2008-07-28

Applicant: Sunyoung Kim

Inventor： Sunyoung Kim

IPC: A61K36/185 ,  A61K39/00 ,  A61K36/258 ,  A61K36/906 ,  A61K36/53 ,  A61K39/395 ,  A61P17/00 ,  A61P11/06 ,  A61P37/02 ,  A61P29/00 ,  A61P37/08

CPC classification number: A61K39/39 ,  A61K39/35

Abstract: Disclosed are novel preparations of Actinidia, and particularly species of hardy kiwifruit, as well as compositions comprising the same. Also disclosed is the use of these preparations of Actinidia to prevent and/or treat a variety of diseases in which regulation of the immune response is effective, including both allergic and non-allergic inflammatory disease, viral infection, and cancer. Methods related to making and using these compositions are also described.

Abstract translation: 公开了猕猴桃的新型制剂，特别是强猕猴桃的种类，以及包含它们的组合物。 还公开了这些猕猴桃制剂的用途，以预防和/或治疗免疫反应调节有效的各种疾病，包括过敏性和非过敏性炎性疾病，病毒感染和癌症。 还描述了制备和使用这些组合物的方法。

公开(公告)号：US07198804B2

公开(公告)日：2007-04-03

申请号：US10411093

申请日：2003-04-11

Applicant: Byung Wook Cho ,  Mirim Jin ,  Hyung-Jin Jung ,  Sunyoung Kim

Inventor： Byung Wook Cho ,  Mirim Jin ,  Hyung-Jin Jung ,  Sunyoung Kim

IPC: A61K36/00 ,  A61K36/906 ,  A61K125/00 ,  A61K36/258 ,  A61K131/00 ,  A61K129/00 ,  A61K36/484

CPC classification number: A61K36/889 ,  A61K36/07 ,  A61K36/185 ,  A61K36/258 ,  A61K36/28 ,  A61K36/284 ,  A61K36/31 ,  A61K36/484 ,  A61K36/575 ,  A61K36/734 ,  A61K36/8905 ,  A61K36/9064 ,  A61K36/9068 ,  A61K2300/00

Abstract: The present invention is related to a crude drug composition essentially comprising herbs of Sinapis Semen Alba, Ginseng Radix, Zingiberis Rhizoma Siccus, Amomi Fructus, Myristicae Semen, Saussureae Radix, Cyperi Rhizoma, Magnoliae Cortex, Arecae Semen, Crataegi Fructus, Atractylodes Rhizoma Alba, Agastachis Herba, Glycyrrhiza Radix and additionally comprising at least one herb selected from group consisting of Polygonati Rhizoma, Artemisiae Argyi Folium, Forsythiae Fructus, Caryophylli Flos, Raphani Semen, Menthae Herba according to the need for the prevention and treatment of gastrointestinal dyskinetic diseases and methods of using the above crude drug composition and pharmaceutical composition as prokinetic agent.

Abstract translation: 本发明涉及一种基本上包含辛酸钠，人参，姜科，i us，肉豆蔻，桑树，仙人掌，厚朴，青ae精，枸杞，白术， Agastachis Herba，甘草，还含有选自Polygonati Rhizoma，Artemisiae Argyi Folium，连翘，Caryophylli Flos，Raphani Semen，Menthae Herba的至少一种草药，根据需要预防和治疗胃肠道运动障碍疾病和方法 使用上述生药组合物和药物组合物作为促动力剂。

公开(公告)号：US07175840B2

公开(公告)日：2007-02-13

申请号：US10220824

申请日：2002-01-03

Applicant: Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

Inventor： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

IPC: A01N63/00 ,  A01N65/00 ,  A61K48/00 ,  A01N43/04 ,  A61K31/715 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

CPC classification number: A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

Abstract: The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

Abstract translation: 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

公开(公告)号：US20060198826A1

公开(公告)日：2006-09-07

申请号：US11431663

申请日：2006-05-11

Applicant: Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

Inventor： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

IPC: A61K48/00 ,  C12N15/86

CPC classification number: A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

Abstract: The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as endostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

Abstract translation: 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如内皮抑素或其部分的基因的重组载体，并且将所述重组载体或转染或转导的细胞移植到所述基因治疗中来提供类风湿性关节炎的基因治疗 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

公开(公告)号：US20060193833A1

公开(公告)日：2006-08-31

申请号：US11431526

申请日：2006-05-11

Applicant: Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

Inventor： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

IPC: A61K48/00

CPC classification number: A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

Abstract: The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as platelet factor-4 or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

Abstract translation: 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如血小板因子-4或其部分的基因的重组载体，并且将重组载体或转染的细胞或其它细胞移植，从而提供类风湿性关节炎的基因治疗 用重组载体转导到患者的受影响区域，并提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

公开(公告)号：US06838280B2

公开(公告)日：2005-01-04

申请号：US10375190

申请日：2003-02-25

Applicant: Sunyoung Kim ,  Seung Shin Yu ,  Youngtae Hong ,  Jong-Mook Kim ,  Eun Young Han

Inventor： Sunyoung Kim ,  Seung Shin Yu ,  Youngtae Hong ,  Jong-Mook Kim ,  Eun Young Han

IPC: A61K48/00 ,  C12N15/867 ,  C12N15/00 ,  C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N2740/13043 ,  C12N2840/20 ,  C12N2840/203

Abstract: The present invention provides a retroviral vector containing an iduronate-2-sulfatase (IDS) gene but without selective marker gene, constructed on, as a backbone, a minimum sized MLV-based retroviral vector which does not contain any viral coding sequences but can still produce a high viral titer and drive a high level of gene expression.

Abstract translation: 本发明提供了一种含有艾杜糖醛酸-2-硫酸酯酶（IDS）基因但没有选择性标记基因的逆转录病毒载体，构建为作为骨架的最小尺寸的基于MLV的逆转录病毒载体，其不包含任何病毒编码序列但仍然可以 产生高病毒滴度并驱动高水平的基因表达。

公开(公告)号：US08599193B2

公开(公告)日：2013-12-03

申请号：US12645478

申请日：2009-12-22

Applicant: Sunyoung Kim ,  Yongwon Jo

Inventor： Sunyoung Kim ,  Yongwon Jo

IPC: G06F3/038

CPC classification number: G09G3/3648 ,  G09G2320/0242 ,  G09G2320/0252 ,  G09G2320/0261 ,  G09G2340/16

Abstract: A liquid crystal display including a first over-driving (OD) compensation unit compensating R data at a first OD rate; a second OD compensation unit compensating G data at a second OD rate; and a third OD compensation unit compensating B data at a third OD rate, where the second OD rate is higher than the first OD rate and the third OD rate.

Abstract translation: 一种液晶显示器，包括以第一OD速率补偿R数据的第一过驱动（OD）补偿单元; 第二OD补偿单元，以第二OD速率补偿G数据; 以及第三OD补偿单元，以第三OD率补偿B数据，其中第二OD率高于第一OD率和第三OD率。

公开(公告)号：US20100218821A1

公开(公告)日：2010-09-02

申请号：US12713487

申请日：2010-02-26

Applicant: Sunyoung KIM ,  Choul KIM ,  Youngho CHOE

Inventor： Sunyoung KIM ,  Choul KIM ,  Youngho CHOE

IPC: H01L31/00

CPC classification number: H01L31/0682 ,  H01L31/02168 ,  H01L31/022441 ,  Y02E10/547

Abstract: A solar cell and a method for manufacturing the same are disclosed. The solar cell includes a substrate having a first conductive type, at least one impurity region connected to the substrate, a passivation layer positioned on the at least one impurity region, the passivation layer including at least one opening exposing a portion of the at least one impurity region, the at least one opening having at least one straight portion, a first electrode connected to the exposed portion of the at least one impurity region exposed through the at least one opening, and a second electrode connected to the substrate.

Abstract translation: 公开了一种太阳能电池及其制造方法。 太阳能电池包括具有第一导电类型的衬底，连接到衬底的至少一个杂质区，位于至少一个杂质区上的钝化层，钝化层包括暴露至少一个的一部分的至少一个开口 所述至少一个开口具有至少一个直线部分，连接到通过所述至少一个开口暴露的所述至少一个杂质区域的暴露部分的第一电极和连接到所述基板的第二电极。